Abstract：
:The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant changes in synaptic plasticity and neuronal connections. Recent studies show that alterations in Ca2+ homeostasis underlie the increased vulnerability of neurons to age-related processes like cognitive decline and synaptic dysfunctions. Dysregulation of Ca2+ can lead to dramatic changes in neuronal functions. We discuss in this review, the recent advances on the potential role of dysregulated Ca2+ homeostasis through altered function of L-type voltage gated Ca2+ channels (LTCC) in ageing, with an emphasis on cognitive decline. This review therefore focuses on age-related changes mainly in the hippocampus, and with mention of other brain areas, that are important for learning and memory. This review also highlights age-related memory deficits via synaptic alterations and neuroinflammation. An understanding of these mechanisms will help us formulate strategies to reverse or ameliorate age-related disorders like cognitive decline.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Navakkode S,Liu C,Soong TWdoi
10.1016/j.arr.2018.01.001subject
Has Abstractpub_date
2018-03-01 00:00:00pages
86-99eissn
1568-1637issn
1872-9649pii
S1568-1637(17)30225-8journal_volume
42pub_type
杂志文章,评审abstract：:Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary theories of aging seek to explain why such stark longevity differences exist and why a deleterious process like aging evolved. The classical mutat...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100947
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100966
更新日期：2019-12-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.10.008
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abstract：:Within the last years, a rapidly growing number of polyphenolic compounds with neuroprotective effects have been described. Many efforts have been made to explore the mechanisms behind the neuroprotective action of polyphenols. However, many pathways and mechanisms considered for mediating these effects are rather gen...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.01.006
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101114
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journal_title：Ageing research reviews
pub_type： 杂志文章
doi：10.1016/j.arr.2010.05.002
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s1568-1637(02)00030-2
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2007.07.002
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.05.006
更新日期：2017-08-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2004.01.003
更新日期：2004-07-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.09.003
更新日期：2013-01-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100961
更新日期：2019-11-01 00:00:00
abstract：:As our world's population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial functio...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.09.002
更新日期：2017-10-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.09.007
更新日期：2017-03-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2006.03.007
更新日期：2006-05-01 00:00:00
abstract：:Clinical studies on intracoronary bone marrow cell (BMCs) infusion in patients with acute myocardial infarction (AMI) revealed mixed results. Recently, meta-analysis on this topic have been conducted and found that there was marked heterogeneity between trials. The objective of this systematic review is to have a retr...
journal_title：Ageing research reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.arr.2010.05.001
更新日期：2010-10-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.03.001
更新日期：2019-05-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.06.001
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2018.03.005
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s0047-6374(01)00368-2
更新日期：2002-02-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.11.006
更新日期：2017-03-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101075
更新日期：2020-08-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.arr.2014.02.004
更新日期：2014-05-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101023
更新日期：2020-03-01 00:00:00
abstract：:Epidemiological and experimental data demonstrate a strong correlation between age-related chronic inflammation (inflamm-aging) and cancer development. However, a comprehensive approach is needed to clarify the underlying molecular mechanisms. Chronic inflammation has mainly been attributed to continuous immune cells ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.05.001
更新日期：2013-09-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2014.12.008
更新日期：2015-09-01 00:00:00
abstract：:Tau phosphorylation is regulated by a balance between tau kinase and phosphatase activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau phosphorylation and thereby that might contributes to tau aggregation. Thus, understanding the regulation modes of tau dephosphorylation is of hi...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.06.008
更新日期：2013-01-01 00:00:00
