Abstract：
:Senescence represents a state of indefinite growth arrest in cells that have reached the end of their replicative life span, have become damaged, or express aberrant levels of cancer-related proteins. While senescence is widely considered to represent a tumor-suppressive mechanism, the accumulation of senescent cells in tissues of older organisms is believed to underlie age-associated losses in physiologic function and age-related diseases. With the emergence of microRNAs (miRNAs) as a major class of molecular regulators of senescence, we review the transcriptional and post-transcriptional factors that control senescence-associated microRNA biosynthesis. Focusing on their enhancement or repression of senescence, we describe the transcription factors that govern the synthesis of primary (pri-)miRNAs, the proteins that control the nuclear processing of pri-miRNAs into precursor (pre-)miRNAs, including RNA editing enzymes, RNases, and RNA helicases, and the cytoplasmic proteins that affect the final processing of pre-miRNAs into mature miRNAs. We discuss how miRNA biogenesis proteins promote or inhibit senescence, and thus influence the senescent phenotype that affects normal tissue function and pathology.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Abdelmohsen K,Srikantan S,Kang MJ,Gorospe Mdoi
10.1016/j.arr.2012.01.003subject
Has Abstractpub_date
2012-09-01 00:00:00pages
491-500issue
4eissn
1568-1637issn
1872-9649pii
S1568-1637(12)00004-9journal_volume
11pub_type
杂志文章,评审abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder involving deposition of misfolded proteins in vulnerable brain regions leading to inexorable and progressive neuronal loss and deterioration of cognitive functions. The AD brain displays features typical of chronic inflammation as defined by the presence of acti...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2011.12.004
更新日期：2012-04-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.09.005
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2014.09.004
更新日期：2014-11-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2014.12.005
更新日期：2015-03-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101155
更新日期：2020-11-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2004.09.003
更新日期：2005-01-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100961
更新日期：2019-11-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2015.12.002
更新日期：2016-03-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.06.001
更新日期：2017-08-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2006.03.006
更新日期：2006-05-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.10.001
更新日期：2014-01-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101089
更新日期：2020-08-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100966
更新日期：2019-12-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.11.002
更新日期：2013-03-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101201
更新日期：2020-12-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2014.12.008
更新日期：2015-09-01 00:00:00
abstract：:Neurons are highly energy demanding cells dependent on the mitochondrial oxidative phosphorylation system. Mitochondria generate energy via respiratory complexes that constitute the electron transport chain. Adenosine triphosphate depletion or glucose starvation act as a trigger for the activation of adenosine monopho...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.09.004
更新日期：2017-11-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101091
更新日期：2020-09-01 00:00:00
abstract：:Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are only partly understood. Therefore, studying the basic mechanisms underlying structural and functional recovery after brain injury in aged subjects is of conside...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.10.008
更新日期：2011-01-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2018.03.001
更新日期：2018-05-01 00:00:00
abstract：:Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.12.007
更新日期：2014-05-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章
doi：10.1016/j.arr.2020.101144
更新日期：2020-11-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.05.001
更新日期：2013-09-01 00:00:00
abstract：:Aging is associated with progressive changes in total and regional fat distribution that have negative health consequences. Indeed, a preferential increase in abdominal fat, in particular visceral fat, combined with a decrease in lower body subcutaneous fat are commonly cited in the literature. These age-related chang...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.06.001
更新日期：2009-10-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.07.001
更新日期：2010-04-01 00:00:00
abstract：:In our ever-aging world population, the risk of age-related neuropathies has been increasing, representing both a social and economic burden to society. Since the ability to regenerate in the adult mammalian central nervous system is very limited, brain trauma and neurodegeneration are often permanent. As a consequenc...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101086
更新日期：2020-09-01 00:00:00
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journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.09.008
更新日期：2017-05-01 00:00:00
abstract：:Caspases are a group of cysteine dependent aspartate-specific proteases. Originally found as the homolog of Ced-3 in C. elegans, 14 caspases have now been identified in mammals to date. Caspases play important roles in both the intrinsic and extrinsic apoptotic pathways and interact with the non-caspase apoptotic path...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s1568-1637(03)00026-6
更新日期：2003-10-01 00:00:00
abstract：:The lysosomal network is the major intracellular proteolytic system accounting for more than 98% of long-lived bulk protein degradation and recycling particularly in tissues such as liver and muscles. Lysosomes are the final destination of intracellular damaged structures, identified and sequestered by the processes o...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.05.001
更新日期：2009-07-01 00:00:00
abstract：:Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system. NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs including Alzheimer's, Parkinson's, Huntington's diseases, Friedreich's Ataxia, Multiple Sclerosis. The exact etiology of NDs is not understood but ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101211
更新日期：2021-01-01 00:00:00
