Abstract:
:Telomeres, the ends of eukaryotic chromosomes, play a central role in the control of cellular senescence and organismal ageing and need to be protected in order to avoid being recognised as damaged DNA and activate DNA damage response pathways. Dysfunctional telomeres arise from critically short telomeres or altered telomere structures, which ultimately lead to replicative cellular senescence and chromosome instability: both hallmarks of ageing. The observation that telomeres are transcribed led to the discovery that telomeric transcripts play important roles in chromosome end protection and genome stability maintenance. Recent evidence indicates that particular long non-coding (nc)RNAs transcribed at telomeres, namely TElomeric Repeat-containing RNA (TERRA) and telomeric damage-induced long ncRNAs (tdilncRNA), play key roles in age-related pathways by actively orchestrating the mechanisms known to regulate telomere length, chromosome end protection and DNA damage signalling. Here, we provide a comprehensive overview of the telomere transcriptome, outlining how it functions as a regulatory platform with essential functions in safeguarding telomere integrity and stability. We next review emerging antisense oligonucleotides therapeutic strategies that target telomeric ncRNAs and discuss their potential for ameliorating ageing and age-related diseases. Altogether, this review provides insights on the biological relevance of telomere transcription mechanisms in human ageing physiology and pathology.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Aguado J,d'Adda di Fagagna F,Wolvetang Edoi
10.1016/j.arr.2020.101115subject
Has Abstractpub_date
2020-09-01 00:00:00pages
101115eissn
1568-1637issn
1872-9649pii
S1568-1637(20)30250-6journal_volume
62pub_type
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2004.05.002
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2016.09.007
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
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