The zebrafish as a gerontology model in nervous system aging, disease, and repair.

Abstract:

:Considering the increasing number of elderly in the world's population today, developing effective treatments for age-related pathologies is one of the biggest challenges in modern medical research. Age-related neurodegeneration, in particular, significantly impacts important sensory, motor, and cognitive functions, seriously constraining life quality of many patients. Although our understanding of the causal mechanisms of aging has greatly improved in recent years, animal model systems still have much to tell us about this complex process. Zebrafish (Danio rerio) have gained enormous popularity for this research topic over the past decade, since their life span is relatively short but, like humans, they are still subject to gradual aging. In addition, the extensive characterization of its well-conserved molecular and cellular physiology makes the zebrafish an excellent model to unravel the underlying mechanisms of aging, disease, and repair. This review provides a comprehensive overview of the progress made in zebrafish gerontology, with special emphasis on nervous system aging. We review the evidence that classic hallmarks of aging can also be recognized within this small vertebrate, both at the molecular and cellular level. Moreover, we illustrate the high level of similarity with age-associated human pathologies through a survey of the functional deficits that arise as zebrafish age.

journal_name

Ageing Res Rev

journal_title

Ageing research reviews

authors

Van Houcke J,De Groef L,Dekeyster E,Moons L

doi

10.1016/j.arr.2015.10.004

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

358-68

issue

Pt B

eissn

1568-1637

issn

1872-9649

pii

S1568-1637(15)30029-5

journal_volume

24

pub_type

杂志文章,评审
  • Neurohypophyseal peptides in aging and Alzheimer's disease.

    abstract::The neurohypophyseal hormones arginine-vasopressin (AVP) and oxytocin (OT) are produced in the neurons of the hypothalamic supraoptic (SON) and paraventricular (PVN) nucleus and in the much smaller cells of the suprachiasmatic (SCN) nucleus. The SON is the main source of plasma AVP. Part of the AVP and OT neurons of t...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1568-1637(02)00013-2

    authors: Ishunina TA,Swaab DF

    更新日期:2002-06-01 00:00:00

  • Revamping the evolutionary theories of aging.

    abstract::Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary theories of aging seek to explain why such stark longevity differences exist and why a deleterious process like aging evolved. The classical mutat...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.100947

    authors: Johnson AA,Shokhirev MN,Shoshitaishvili B

    更新日期:2019-11-01 00:00:00

  • Wnt signaling pathway in aging-related tissue fibrosis and therapies.

    abstract::Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the pathogenesis of various chronic diseases and aging-related organ failure to fully control chronic wound-healing and restoring tissue function. The process of fibrosis is involved in the pathogenesis of the kidney, lung, live...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101063

    authors: Hu HH,Cao G,Wu XQ,Vaziri ND,Zhao YY

    更新日期:2020-07-01 00:00:00

  • Sunlight and health: shifting the focus from vitamin D3 to photobiomodulation by red and near-infrared light.

    abstract::Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast bod...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101089

    authors: Heiskanen V,Pfiffner M,Partonen T

    更新日期:2020-08-01 00:00:00

  • Pentraxins and Alzheimer's disease: at the interface between biomarkers and pharmacological targets.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder involving deposition of misfolded proteins in vulnerable brain regions leading to inexorable and progressive neuronal loss and deterioration of cognitive functions. The AD brain displays features typical of chronic inflammation as defined by the presence of acti...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2011.12.004

    authors: Osera C,Pascale A,Amadio M,Venturini L,Govoni S,Ricevuti G

    更新日期:2012-04-01 00:00:00

  • The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease.

    abstract::Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system. NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs including Alzheimer's, Parkinson's, Huntington's diseases, Friedreich's Ataxia, Multiple Sclerosis. The exact etiology of NDs is not understood but ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101211

    authors: Kahroba H,Ramezani B,Maadi H,Sadeghi MR,Jaberie H,Ramezani F

    更新日期:2021-01-01 00:00:00

  • Remote tissue conditioning - An emerging approach for inducing body-wide protection against diseases of ageing.

    abstract::We have long accepted that exercise is 'good for us'; that - put more rigorously - moderate exercise is associated with not just aerobic fitness but also reduced morbidity and reduced mortality from cardiovascular disease and even malignancies. Caloric restriction (moderate hunger) and our exposure to dietary phytoche...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2017.05.005

    authors: Kim B,Brandli A,Mitrofanis J,Stone J,Purushothuman S,Johnstone DM

    更新日期:2017-08-01 00:00:00

  • The role of inflammasome in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2013.12.007

    authors: Liu L,Chan C

    更新日期:2014-05-01 00:00:00

  • Reactive oxygen species and synaptic plasticity in the aging hippocampus.

    abstract::Aging is associated with a general decline in physiological functions including cognitive functions. Given that the hippocampus is known to be critical for certain forms of learning and memory, it is not surprising that a number of neuronal processes in this brain area appear to be particularly vulnerable to the aging...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2004.05.002

    authors: Serrano F,Klann E

    更新日期:2004-11-01 00:00:00

  • Lessons learned from gene expression profile studies of aging and caloric restriction.

    abstract::To examine molecular events associated with aging and its retardation by caloric restriction (CR), we have employed high-density oligonucleotide microarrays to define transcriptional patterns in mouse tissues, including skeletal muscle, brain, heart, and adipose. Aging results in a differential gene expression pattern...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2004.09.003

    authors: Park SK,Prolla TA

    更新日期:2005-01-01 00:00:00

  • Caloric restriction and longevity: effects of reduced body temperature.

    abstract::Caloric restriction (CR) causes a reduction in body temperature (T(b)) which is suggested to contribute to changes that increase lifespan. Moreover, low T(b) has been shown to improve health and longevity independent of CR. In this review we examine the connections between CR, T(b) and mechanisms that influence longev...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2010.10.001

    authors: Carrillo AE,Flouris AD

    更新日期:2011-01-01 00:00:00

  • The impact of sarcopenia and exercise training on skeletal muscle satellite cells.

    abstract::It has been well-established that the age-related loss of muscle mass and strength, or sarcopenia, impairs skeletal muscle function and reduces functional performance at a more advanced age. Skeletal muscle satellite cells (SC), as precursors of new myonuclei, have been suggested to be involved in the development of s...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2009.05.003

    authors: Snijders T,Verdijk LB,van Loon LJ

    更新日期:2009-10-01 00:00:00

  • Aging of cerebral white matter.

    abstract::White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas,...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2016.11.006

    authors: Liu H,Yang Y,Xia Y,Zhu W,Leak RK,Wei Z,Wang J,Hu X

    更新日期:2017-03-01 00:00:00

  • Do not neglect the role of circadian rhythm in muscle atrophy.

    abstract::In addition to its role in movement, human skeletal muscle also plays important roles in physiological activities related to metabolism and the endocrine system. Aging and disease onset and progression can induce the reduction of skeletal muscle mass and function, thereby exacerbating skeletal muscle atrophy. Recent s...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101155

    authors: Zhang H,Liang J,Chen N

    更新日期:2020-11-01 00:00:00

  • Effects of physical exercise therapy on mobility, physical functioning, physical activity and quality of life in community-dwelling older adults with impaired mobility, physical disability and/or multi-morbidity: a meta-analysis.

    abstract::This is the first meta-analysis focusing on elderly patients with mobility problems, physical disability and/or multi-morbidity. The aim of this study is to assess the effect of physical exercise therapy on mobility, physical functioning, physical activity and quality of life. A broad systematic literature search was ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.arr.2011.11.002

    authors: de Vries NM,van Ravensberg CD,Hobbelen JS,Olde Rikkert MG,Staal JB,Nijhuis-van der Sanden MW

    更新日期:2012-01-01 00:00:00

  • Discovering causes and cures for cancer from gene expression analysis.

    abstract::Tumorigenesis is governed by a series of complex genetic and epigenetic changes. Both mechanisms can result in either the silencing or aberrant expression of messages in a cell. Gene expression profiling techniques such as the serial analysis of gene expression (SAGE) or microarray analysis can provide global overview...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2005.06.004

    authors: Weeraratna AT

    更新日期:2005-11-01 00:00:00

  • Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing.

    abstract::A-T is a prototype genome instability syndrome and a multifaceted disease. A-T leads to neurodegeneration - primarily cerebellar atrophy, immunodeficiency, oculocutaneous telangiectasia (dilated blood vessels), vestigial thymus and gonads, endocrine abnormalities, cancer predisposition and varying sensitivity to DNA d...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2016.05.002

    authors: Shiloh Y,Lederman HM

    更新日期:2017-01-01 00:00:00

  • Resilience in older persons: A systematic review of the conceptual literature.

    abstract::Although ageing research increasingly incorporates resilience, a common notion on what resilience means is lacking. We aimed to give a comprehensive overview of the conceptual literature on resilience in older persons, identifying areas of consensus and variation/debate. A systematic search of eight databases from dif...

    journal_title:Ageing research reviews

    pub_type: 杂志文章

    doi:10.1016/j.arr.2020.101144

    authors: Angevaare MJ,Roberts J,van Hout HPJ,Joling KJ,Smalbrugge M,Schoonmade LJ,Windle G,Hertogh CMPM

    更新日期:2020-11-01 00:00:00

  • Cancer-free aging: Insights from Spalax ehrenbergi superspecies.

    abstract::Cancer and ageing can be regarded as two different manifestations of the same underlying process-accumulation of cellular damage-and therefore both are closely linked. Nowadays, the ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities, and therefore the understanding o...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2018.06.004

    authors: Lagunas-Rangel FA

    更新日期:2018-11-01 00:00:00

  • Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?

    abstract::The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and a vascular disease in severe patients. The damage endothelial system provides a good explanat...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101201

    authors: Guan SP,Seet RCS,Kennedy BK

    更新日期:2020-12-01 00:00:00

  • Aging in blood vessels. Medicinal agents FOR systemic arterial hypertension in the elderly.

    abstract::Aging impairs blood vessel function and leads to cardiovascular disease. The mechanisms underlying the age-related endothelial, smooth muscle and extracellular matrix vascular dysfunction are discussed. Vascular dysfunction is caused by: (1) Oxidative stress enhancement. (2) Reduction of nitric oxide (NO) bioavailabil...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2014.10.001

    authors: Rubio-Ruiz ME,Pérez-Torres I,Soto ME,Pastelín G,Guarner-Lans V

    更新日期:2014-11-01 00:00:00

  • The impact of cerebrovascular aging on vascular cognitive impairment and dementia.

    abstract::As human life expectancy rises, the aged population will increase. Aging is accompanied by changes in tissue structure, often resulting in functional decline. For example, aging within blood vessels contributes to a decrease in blood flow to important organs, potentially leading to organ atrophy and loss of function. ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2016.09.007

    authors: Yang T,Sun Y,Lu Z,Leak RK,Zhang F

    更新日期:2017-03-01 00:00:00

  • Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases.

    abstract::Neurons are highly energy demanding cells dependent on the mitochondrial oxidative phosphorylation system. Mitochondria generate energy via respiratory complexes that constitute the electron transport chain. Adenosine triphosphate depletion or glucose starvation act as a trigger for the activation of adenosine monopho...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2017.09.004

    authors: Shah SZA,Zhao D,Hussain T,Yang L

    更新日期:2017-11-01 00:00:00

  • Selective neuronal vulnerability in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is defined by a deficiency in specific behavioural and/or cognitive domains, pointing to selective vulnerabilities of specific neurons from different brain regions. These vulnerabilities can be compared across neuron subgroups to identify the most vulnerable neuronal types, regions, and time p...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101114

    authors: Wang ZT,Zhang C,Wang YJ,Dong Q,Tan L,Yu JT

    更新日期:2020-09-01 00:00:00

  • The role of DNA methylation and hydroxymethylation in immunosenescence.

    abstract::A healthy functioning immune system is critical to stave off infectious diseases, but as humans and other organisms age, their immune systems decline. As a result, diseases that were readily thwarted in early life pose nontrivial harm and can even be deadly in late life. Immunosenescence is defined as the general dete...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.01.011

    authors: Johnson ND,Conneely KN

    更新日期:2019-05-01 00:00:00

  • MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?

    abstract::The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101075

    authors: Elliott ML

    更新日期:2020-08-01 00:00:00

  • A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease.

    abstract::The postsynaptic density protein PSD-95 is a major element of synapses. PSD-95 is involved in aging, Alzheimer's disease (AD) and numerous psychiatric disorders. However, contradictory data about PSD-95 expression in aging and AD have been reported. Indeed in AD versus control brains PSD-95 varies according to regions...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2014.09.004

    authors: Savioz A,Leuba G,Vallet PG

    更新日期:2014-11-01 00:00:00

  • Altered function of neuronal L-type calcium channels in ageing and neuroinflammation: Implications in age-related synaptic dysfunction and cognitive decline.

    abstract::The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2018.01.001

    authors: Navakkode S,Liu C,Soong TW

    更新日期:2018-03-01 00:00:00

  • Bioenergetics of aging and calorie restriction.

    abstract::Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused o...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2006.03.006

    authors: Hunt ND,Hyun DH,Allard JS,Minor RK,Mattson MP,Ingram DK,de Cabo R

    更新日期:2006-05-01 00:00:00

  • Where are we now in relation to determining the prevalence of ageism in this era of escalating population ageing?

    abstract::Population ageing is escalating rapidly now worldwide. This is an important time to determine if ageism or discrimination against older people is of concern, such as it being prevalent and/or increasing in prevalence. Over the years, many ageism measurement tools have been developed, with research findings from their ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.03.001

    authors: Wilson DM,Errasti-Ibarrondo B,Low G

    更新日期:2019-05-01 00:00:00