The zebrafish as a gerontology model in nervous system aging, disease, and repair.

Abstract:

:Considering the increasing number of elderly in the world's population today, developing effective treatments for age-related pathologies is one of the biggest challenges in modern medical research. Age-related neurodegeneration, in particular, significantly impacts important sensory, motor, and cognitive functions, seriously constraining life quality of many patients. Although our understanding of the causal mechanisms of aging has greatly improved in recent years, animal model systems still have much to tell us about this complex process. Zebrafish (Danio rerio) have gained enormous popularity for this research topic over the past decade, since their life span is relatively short but, like humans, they are still subject to gradual aging. In addition, the extensive characterization of its well-conserved molecular and cellular physiology makes the zebrafish an excellent model to unravel the underlying mechanisms of aging, disease, and repair. This review provides a comprehensive overview of the progress made in zebrafish gerontology, with special emphasis on nervous system aging. We review the evidence that classic hallmarks of aging can also be recognized within this small vertebrate, both at the molecular and cellular level. Moreover, we illustrate the high level of similarity with age-associated human pathologies through a survey of the functional deficits that arise as zebrafish age.

journal_name

Ageing Res Rev

journal_title

Ageing research reviews

authors

Van Houcke J,De Groef L,Dekeyster E,Moons L

doi

10.1016/j.arr.2015.10.004

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

358-68

issue

Pt B

eissn

1568-1637

issn

1872-9649

pii

S1568-1637(15)30029-5

journal_volume

24

pub_type

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