The zebrafish as a gerontology model in nervous system aging, disease, and repair.


:Considering the increasing number of elderly in the world's population today, developing effective treatments for age-related pathologies is one of the biggest challenges in modern medical research. Age-related neurodegeneration, in particular, significantly impacts important sensory, motor, and cognitive functions, seriously constraining life quality of many patients. Although our understanding of the causal mechanisms of aging has greatly improved in recent years, animal model systems still have much to tell us about this complex process. Zebrafish (Danio rerio) have gained enormous popularity for this research topic over the past decade, since their life span is relatively short but, like humans, they are still subject to gradual aging. In addition, the extensive characterization of its well-conserved molecular and cellular physiology makes the zebrafish an excellent model to unravel the underlying mechanisms of aging, disease, and repair. This review provides a comprehensive overview of the progress made in zebrafish gerontology, with special emphasis on nervous system aging. We review the evidence that classic hallmarks of aging can also be recognized within this small vertebrate, both at the molecular and cellular level. Moreover, we illustrate the high level of similarity with age-associated human pathologies through a survey of the functional deficits that arise as zebrafish age.


Ageing Res Rev


Ageing research reviews


Van Houcke J,De Groef L,Dekeyster E,Moons L




Has Abstract


2015-11-01 00:00:00




Pt B










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    authors: Heiskanen V,Pfiffner M,Partonen T

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    authors: Kahroba H,Ramezani B,Maadi H,Sadeghi MR,Jaberie H,Ramezani F

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    pub_type: 杂志文章,评审


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    journal_title:Ageing research reviews

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    更新日期:2019-05-01 00:00:00

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    更新日期:2020-08-01 00:00:00

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    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Savioz A,Leuba G,Vallet PG

    更新日期:2014-11-01 00:00:00

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    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Navakkode S,Liu C,Soong TW

    更新日期:2018-03-01 00:00:00

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    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Hunt ND,Hyun DH,Allard JS,Minor RK,Mattson MP,Ingram DK,de Cabo R

    更新日期:2006-05-01 00:00:00

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    abstract::Population ageing is escalating rapidly now worldwide. This is an important time to determine if ageism or discrimination against older people is of concern, such as it being prevalent and/or increasing in prevalence. Over the years, many ageism measurement tools have been developed, with research findings from their ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Wilson DM,Errasti-Ibarrondo B,Low G

    更新日期:2019-05-01 00:00:00