The eye as a model of ageing in translational research--molecular, epigenetic and clinical aspects.

Abstract:

:The eye and visual system are valuable in many areas of translational research such as stem cell therapy, transplantation research and gene therapy. Changes in many ocular tissues can be measured directly, easily and objectively in vivo (e.g. lens transparency; retinal blood vessel calibre; corneal endothelial cell counts) and so the eye may also be a uniquely useful site as a model of ageing. This review details cellular, molecular and epigenetic mechanisms related to ageing within the eye, and describes ocular parameters that can be directly measured clinically and which might be of value in ageing research as the translational "window to the rest of the body". The eye is likely to provide a valuable model for validating biomarkers of ageing at molecular, epigenetic, cellular and clinical levels. A research agenda to definitively establish the relationship between biomarkers of ageing and ocular parameters is proposed.

journal_name

Ageing Res Rev

journal_title

Ageing research reviews

authors

Pathai S,Shiels PG,Lawn SD,Cook C,Gilbert C

doi

10.1016/j.arr.2012.11.002

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

490-508

issue

2

eissn

1568-1637

issn

1872-9649

pii

S1568-1637(12)00148-1

journal_volume

12

pub_type

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