Abstract:
:Persons aged 80 years and older are the fastest growing segment of the population. As more individuals live longer, we should try to understand the mechanisms involved in healthy ageing and preserving functional independence in later life. In elderly people, functional independence is directly dependent on physical fitness, and ageing is inevitably associated with the declining functions of systems and organs (heart, lungs, blood vessels, skeletal muscles) that determine physical fitness. Thus, age-related diminished physical fitness contributes to the development of sarcopenia, frailty or disability, all of which severely deteriorate independent living and thus quality of life. Ageing is a complex process involving many variables that interact with one another, including - besides lifestyle factors or chronic diseases - genetics. Thus, several studies have examined the contribution of genetic endowment to a decline in physical fitness and subsequent loss of independence in later life. In this review, we compile information, including data from heritability, candidate-gene association, linkage and genome-wide association studies, on genetic factors that could influence physical fitness in the elderly.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Garatachea N,Lucia Adoi
10.1016/j.arr.2012.09.003subject
Has Abstractpub_date
2013-01-01 00:00:00pages
90-102issue
1eissn
1568-1637issn
1872-9649pii
S1568-1637(12)00139-0journal_volume
12pub_type
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2004.09.003
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2019.04.001
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.07.001
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2014.09.002
更新日期:2014-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2016.05.002
更新日期:2017-01-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.05.001
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.01.001
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2012.11.002
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journal_title:Ageing research reviews
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doi:10.1016/j.arr.2010.05.003
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journal_title:Ageing research reviews
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pub_type: 杂志文章,评审
doi:10.1016/j.arr.2006.03.006
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journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
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journal_title:Ageing research reviews
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