The impact of cerebrovascular aging on vascular cognitive impairment and dementia.

Abstract:

:As human life expectancy rises, the aged population will increase. Aging is accompanied by changes in tissue structure, often resulting in functional decline. For example, aging within blood vessels contributes to a decrease in blood flow to important organs, potentially leading to organ atrophy and loss of function. In the central nervous system, cerebral vascular aging can lead to loss of the integrity of the blood-brain barrier, eventually resulting in cognitive and sensorimotor decline. One of the major of types of cognitive dysfunction due to chronic cerebral hypoperfusion is vascular cognitive impairment and dementia (VCID). In spite of recent progress in clinical and experimental VCID research, our understanding of vascular contributions to the pathogenesis of VCID is still very limited. In this review, we summarize recent findings on VCID, with a focus on vascular age-related pathologies and their contribution to the development of this condition.

journal_name

Ageing Res Rev

journal_title

Ageing research reviews

authors

Yang T,Sun Y,Lu Z,Leak RK,Zhang F

doi

10.1016/j.arr.2016.09.007

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

15-29

eissn

1568-1637

issn

1872-9649

pii

S1568-1637(16)30118-0

journal_volume

34

pub_type

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