Designing neuroreparative strategies using aged regenerating animal models.

Abstract:

:In our ever-aging world population, the risk of age-related neuropathies has been increasing, representing both a social and economic burden to society. Since the ability to regenerate in the adult mammalian central nervous system is very limited, brain trauma and neurodegeneration are often permanent. As a consequence, novel scientific challenges have emerged and many research efforts currently focus on triggering repair in the damaged or diseased brain. Nevertheless, stimulating neuroregeneration remains ambitious. Even though important discoveries have been made over the past decades, they did not translate into a therapy yet. Actually, this is not surprising; while these disorders mainly manifest in aged individuals, most of the research is being performed in young animal models. Aging of neurons and their environment, however, greatly affects the central nervous system and its capacity to repair. This review provides a detailed overview of the impact of aging on central nervous system functioning and regeneration potential, both in non-regenerating and spontaneously regenerating animal models. Additionally, we highlight the need for aging animal models with regenerative capacities in the search for neuroreparative strategies.

journal_name

Ageing Res Rev

journal_title

Ageing research reviews

authors

Vanhunsel S,Beckers A,Moons L

doi

10.1016/j.arr.2020.101086

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

101086

eissn

1568-1637

issn

1872-9649

pii

S1568-1637(20)30221-X

journal_volume

62

pub_type

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