Abstract：
:The safest place to store lipids is the white adipose tissue, but its storage capacity may become saturated resulting in excess of fat "overspilled" to non-adipose tissues. This overspill of fat occurs in apparently opposite pathological states such as lipodistrophy or obesity. When the excess of energy is redirected towards peripheral organs, their initial response is to facilitate the storage of the surplus in the form of triacylglycerol, but the limited triacylglycerol buffer capacity becomes saturated soon. Under these conditions excess of lipids enter alternative non-oxidative pathways that result in production of toxic reactive lipid species that induce organ-specific toxic responses leading to apoptosis. Reactive lipids can accumulate in non-adipose tissues of metabolically relevant organs such as pancreatic beta-cells, liver, heart and skeletal muscle leading to lipotoxicity, a process that contributes substantially to the pathophysiology of insulin resistance, type 2 diabetes, steatotic liver disease and heart failure. The effects of this lipotoxic insult can be minimised by several strategies: (a) decreased incorporation of energy, (b) a less orthodox approach such as increased adipose tissue expandability and/or (c) increased oxidation of fat in peripheral organs. Aging should be considered as physiological degenerative process potentially accelerated by concomitant lipotoxic insults. Conversely, the process of aging can sensitise cells to effects of lipid toxicity.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Slawik M,Vidal-Puig AJdoi
10.1016/j.arr.2006.03.004subject
Has Abstractpub_date
2006-05-01 00:00:00pages
144-64issue
2eissn
1568-1637issn
1872-9649pii
S1568-1637(06)00030-4journal_volume
5pub_type
杂志文章,评审abstract：:Aging is the main risk factor contributing to vascular dysfunction and the progression of vascular diseases. In this review, we discuss the causes and mechanisms of vascular aging at the tissue and cellular level. We focus on Endothelial Cell (EC) and Smooth Muscle Cell (SMC) aging due to their critical role in mediat...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.05.006
更新日期：2017-08-01 00:00:00
abstract：:The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and a vascular disease in severe patients. The damage endothelial system provides a good explanat...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101201
更新日期：2020-12-01 00:00:00
abstract：:A wide array of cell signaling mediators and their interactions play vital roles in neuroinflammation associated with ischemia, brain trauma, developmental disorders and age-related neurodegeneration. Along with neurons, microglia and astrocytes are also affected by the inflammatory cascade by releasing pro-inflammato...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.02.004
更新日期：2017-07-01 00:00:00
abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder involving deposition of misfolded proteins in vulnerable brain regions leading to inexorable and progressive neuronal loss and deterioration of cognitive functions. The AD brain displays features typical of chronic inflammation as defined by the presence of acti...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2011.12.004
更新日期：2012-04-01 00:00:00
abstract：:A-T is a prototype genome instability syndrome and a multifaceted disease. A-T leads to neurodegeneration - primarily cerebellar atrophy, immunodeficiency, oculocutaneous telangiectasia (dilated blood vessels), vestigial thymus and gonads, endocrine abnormalities, cancer predisposition and varying sensitivity to DNA d...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.05.002
更新日期：2017-01-01 00:00:00
abstract：:Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary theories of aging seek to explain why such stark longevity differences exist and why a deleterious process like aging evolved. The classical mutat...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100947
更新日期：2019-11-01 00:00:00
abstract：:Developments in technology have facilitated quantitative examination of gaze behavior in relation to locomotion. The objective of this systematic review is to provide a critical evaluation of available evidence and to explore the role of gaze behavior among older adults during different forms of locomotion. Database s...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2014.12.005
更新日期：2015-03-01 00:00:00
abstract：:White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas,...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.11.006
更新日期：2017-03-01 00:00:00
abstract：:Aging is associated with a general decline in physiological functions including cognitive functions. Given that the hippocampus is known to be critical for certain forms of learning and memory, it is not surprising that a number of neuronal processes in this brain area appear to be particularly vulnerable to the aging...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2004.05.002
更新日期：2004-11-01 00:00:00
abstract：:Coronary artery disease is the leading cause of death in industrialized countries for people older than 65 years of age. The reasons are still unclear. A reduction of endogenous mechanisms against ischemic insults has been proposed to explain this phenomenon. Cardiac ischemic preconditioning represents the most powerf...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.07.001
更新日期：2010-04-01 00:00:00
abstract：:The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2018.01.001
更新日期：2018-03-01 00:00:00
abstract：:Alternative splicing is a co-transcriptional process, which allows for the production of multiple transcripts from a single gene and is emerging as an important control point for gene expression. Alternatively expressed isoforms often have antagonistic function and differential temporal or spatial expression patterns,...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.04.004
更新日期：2017-07-01 00:00:00
abstract：:To study human aging is an enormous challenge. The complexity of the aging phenotype and the near impossibility of studying aging directly in humans oblige researchers to resort to models and extrapolations. Computational approaches offer a powerful set of tools to study human aging. In one direction we have data-mini...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2003.08.006
更新日期：2004-04-01 00:00:00
abstract：:Caspases are a group of cysteine dependent aspartate-specific proteases. Originally found as the homolog of Ced-3 in C. elegans, 14 caspases have now been identified in mammals to date. Caspases play important roles in both the intrinsic and extrinsic apoptotic pathways and interact with the non-caspase apoptotic path...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s1568-1637(03)00026-6
更新日期：2003-10-01 00:00:00
abstract：:The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first reported in Wuhan, China in December 2019, moved across the globe at an unprecedented speed, and is having a profound and yet still unfolding health and socioeconomic impacts. SARS-CoV-2, a β-coronavirus, is a highly contagious respira...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101205
更新日期：2021-01-01 00:00:00
abstract：:Age-related hearing loss, known as presbyacusis, is characterized by the progressive deterioration of auditory sensitivity associated with aging and is the most common cause of adult auditory deficiency in the United States. Presbyacusis is defined as a progressive, bilateral, high-frequency hearing loss that is manif...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s1568-1637(02)00004-1
更新日期：2002-06-01 00:00:00
abstract：:This is the first meta-analysis focusing on elderly patients with mobility problems, physical disability and/or multi-morbidity. The aim of this study is to assess the effect of physical exercise therapy on mobility, physical functioning, physical activity and quality of life. A broad systematic literature search was ...
journal_title：Ageing research reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.arr.2011.11.002
更新日期：2012-01-01 00:00:00
abstract：:A healthy functioning immune system is critical to stave off infectious diseases, but as humans and other organisms age, their immune systems decline. As a result, diseases that were readily thwarted in early life pose nontrivial harm and can even be deadly in late life. Immunosenescence is defined as the general dete...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.01.011
更新日期：2019-05-01 00:00:00
abstract：:The neurohypophyseal hormones arginine-vasopressin (AVP) and oxytocin (OT) are produced in the neurons of the hypothalamic supraoptic (SON) and paraventricular (PVN) nucleus and in the much smaller cells of the suprachiasmatic (SCN) nucleus. The SON is the main source of plasma AVP. Part of the AVP and OT neurons of t...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s1568-1637(02)00013-2
更新日期：2002-06-01 00:00:00
abstract：:Some of the needs that people with dementia and their informal carers currently perceive as insufficiently met by regular care and support services might be alleviated, or even be met, using modern Information and Communication Technology (ICT). The study described in this paper was designed to provide an insight into...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2007.07.002
更新日期：2007-10-01 00:00:00
abstract：:Telomeres, the ends of eukaryotic chromosomes, play a central role in the control of cellular senescence and organismal ageing and need to be protected in order to avoid being recognised as damaged DNA and activate DNA damage response pathways. Dysfunctional telomeres arise from critically short telomeres or altered t...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101115
更新日期：2020-09-01 00:00:00
abstract：:Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, c...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2010.08.006
更新日期：2010-11-01 00:00:00
abstract：:It is well known that atherosclerosis prevails in elderly populations as ageing acts as a recognized risk factor for this disease. Although the pathogenic factors leading to atherosclerosis are highly heterogeneous, traditionally speaking, the causative risk factors include hyperlipidemia, hypertension, diabetes melli...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2007.01.001
更新日期：2007-08-01 00:00:00
abstract：:Autophagy is a lysosomal degradation process and protective housekeeping mechanism to eliminate damaged organelles, long-lived misfolded proteins and invading pathogens. Autophagy functions to recycle building blocks and energy for cellular renovation and homeostasis, allowing cells to adapt to stress. Modulation of a...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2018.08.004
更新日期：2018-11-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite the tremendous efforts researchers have put into AD research, there are no effective options for prevention and treatment of the disease. The best way to reach this goal is to clarify the mechanisms involved in the onset and progr...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100966
更新日期：2019-12-01 00:00:00
abstract：:Aging is associated with progressive changes in total and regional fat distribution that have negative health consequences. Indeed, a preferential increase in abdominal fat, in particular visceral fat, combined with a decrease in lower body subcutaneous fat are commonly cited in the literature. These age-related chang...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.06.001
更新日期：2009-10-01 00:00:00
abstract：:Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and are increasingly used to track organisms along their life-course. This allows investigation into how aging affects cellular transcriptomes, and how changes in transcriptomes may underlie aging, including chronic inflammation (infl...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101156
更新日期：2020-12-01 00:00:00
abstract：:The use of non-human primate models is required to understand the ageing process and evaluate new therapies against age-associated pathologies. The present article summarizes all the contributions of the grey mouse lemur Microcebus murinus, a small nocturnal prosimian primate, to the understanding of the mechanisms of...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2011.07.001
更新日期：2012-01-01 00:00:00
abstract：:Undernutrition without malnutrition is an intervention that enhances laboratory animal life span, and is widely studied to uncover factors limiting longevity. In a search of the literature over a course of four years, we found that most protocols currently adopted as caloric restriction do not meet micronutrient stand...
journal_title：Ageing research reviews
pub_type： 杂志文章
doi：10.1016/j.arr.2010.05.002
更新日期：2010-10-01 00:00:00
abstract：:Aging effects have often been reported for spatial navigation performance. Moreover, navigation performance is thought to be an early marker of pathological aging. Yet, the cognitive complexity of navigation and large individual variation in healthy population make it difficult to pinpoint the precise aging mechanisms...
journal_title：Ageing research reviews
pub_type： 杂志文章
doi：10.1016/j.arr.2020.101020
更新日期：2020-03-01 00:00:00
