Aging of the human adrenal cortex.

Abstract:

:The aging of the human adrenal cortex presents several problems of interest to the cell biologist, as the interplay of changes in growth, differentiation, apoptosis and cellular senescence affect the properties of the tissue over the life span. The human adrenal cortex also presents an interesting case of tumor progression, as nodules and adenomas are very common in aging, although carcinomas are rare. A specific puzzle for the gerontologist is the loss of biosynthesis of dehydroepiandrosterone (DHEA) and its sulfate by the human adrenal cortex in aging. The reason for the development of a specific zone of DHEA-secreting cells, the zona reticularis, in childhood and the later involution of this zone is completely unknown. This review explores these issues, the underlying basic cell and molecular biology, and the techniques that can address these questions.

journal_name

Ageing Res Rev

journal_title

Ageing research reviews

authors

Hornsby PJ

doi

10.1016/s1568-1637(01)00007-1

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

229-42

issue

2

eissn

1568-1637

issn

1872-9649

pii

S1568163701000071

journal_volume

1

pub_type

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