Aging of the human adrenal cortex.


:The aging of the human adrenal cortex presents several problems of interest to the cell biologist, as the interplay of changes in growth, differentiation, apoptosis and cellular senescence affect the properties of the tissue over the life span. The human adrenal cortex also presents an interesting case of tumor progression, as nodules and adenomas are very common in aging, although carcinomas are rare. A specific puzzle for the gerontologist is the loss of biosynthesis of dehydroepiandrosterone (DHEA) and its sulfate by the human adrenal cortex in aging. The reason for the development of a specific zone of DHEA-secreting cells, the zona reticularis, in childhood and the later involution of this zone is completely unknown. This review explores these issues, the underlying basic cell and molecular biology, and the techniques that can address these questions.


Ageing Res Rev


Ageing research reviews


Hornsby PJ





Has Abstract


2002-04-01 00:00:00














  • Reactive oxygen species and synaptic plasticity in the aging hippocampus.

    abstract::Aging is associated with a general decline in physiological functions including cognitive functions. Given that the hippocampus is known to be critical for certain forms of learning and memory, it is not surprising that a number of neuronal processes in this brain area appear to be particularly vulnerable to the aging...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Serrano F,Klann E

    更新日期:2004-11-01 00:00:00

  • The grey mouse lemur: a non-human primate model for ageing studies.

    abstract::The use of non-human primate models is required to understand the ageing process and evaluate new therapies against age-associated pathologies. The present article summarizes all the contributions of the grey mouse lemur Microcebus murinus, a small nocturnal prosimian primate, to the understanding of the mechanisms of...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Languille S,Blanc S,Blin O,Canale CI,Dal-Pan A,Devau G,Dhenain M,Dorieux O,Epelbaum J,Gomez D,Hardy I,Henry PY,Irving EA,Marchal J,Mestre-Francés N,Perret M,Picq JL,Pifferi F,Rahman A,Schenker E,Terrien J,Théry

    更新日期:2012-01-01 00:00:00

  • Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?

    abstract::The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and a vascular disease in severe patients. The damage endothelial system provides a good explanat...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Guan SP,Seet RCS,Kennedy BK

    更新日期:2020-12-01 00:00:00

  • Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins.

    abstract::Functional activities of mature human neutrophils are strongly influenced by the pro-inflammatory cytokine granulocyte macrophage-colony stimulating factor (GM-CSF). Accordingly, a defective response to GM-CSF might have dramatic consequences for neutrophil functions and the host defence against infections. Such an ev...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Tortorella C,Simone O,Piazzolla G,Stella I,Antonaci S

    更新日期:2007-08-01 00:00:00

  • Inflammation and frailty in the elderly: A systematic review and meta-analysis.

    abstract::The pathogenesis of frailty and the role of inflammation is poorly understood. We examined the evidence considering the relationship between inflammation and frailty through a systematic review and meta-analysis. A systematic literature search of papers providing data on inflammatory biomarkers and frailty was carried...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Soysal P,Stubbs B,Lucato P,Luchini C,Solmi M,Peluso R,Sergi G,Isik AT,Manzato E,Maggi S,Maggio M,Prina AM,Cosco TD,Wu YT,Veronese N

    更新日期:2016-11-01 00:00:00

  • The eye as a model of ageing in translational research--molecular, epigenetic and clinical aspects.

    abstract::The eye and visual system are valuable in many areas of translational research such as stem cell therapy, transplantation research and gene therapy. Changes in many ocular tissues can be measured directly, easily and objectively in vivo (e.g. lens transparency; retinal blood vessel calibre; corneal endothelial cell co...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Pathai S,Shiels PG,Lawn SD,Cook C,Gilbert C

    更新日期:2013-03-01 00:00:00

  • Age, gender and diabetic status are associated with effects of bone marrow cell therapy on recovery of left ventricular function after acute myocardial infarction: a systematic review and meta-analysis.

    abstract::Clinical studies on intracoronary bone marrow cell (BMCs) infusion in patients with acute myocardial infarction (AMI) revealed mixed results. Recently, meta-analysis on this topic have been conducted and found that there was marked heterogeneity between trials. The objective of this systematic review is to have a retr...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Bai Y,Sun T,Ye P

    更新日期:2010-10-01 00:00:00

  • Age-related changes in total and regional fat distribution.

    abstract::Aging is associated with progressive changes in total and regional fat distribution that have negative health consequences. Indeed, a preferential increase in abdominal fat, in particular visceral fat, combined with a decrease in lower body subcutaneous fat are commonly cited in the literature. These age-related chang...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Kuk JL,Saunders TJ,Davidson LE,Ross R

    更新日期:2009-10-01 00:00:00

  • Effects of physical exercise therapy on mobility, physical functioning, physical activity and quality of life in community-dwelling older adults with impaired mobility, physical disability and/or multi-morbidity: a meta-analysis.

    abstract::This is the first meta-analysis focusing on elderly patients with mobility problems, physical disability and/or multi-morbidity. The aim of this study is to assess the effect of physical exercise therapy on mobility, physical functioning, physical activity and quality of life. A broad systematic literature search was ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析,评审


    authors: de Vries NM,van Ravensberg CD,Hobbelen JS,Olde Rikkert MG,Staal JB,Nijhuis-van der Sanden MW

    更新日期:2012-01-01 00:00:00

  • Regulation of senescence by microRNA biogenesis factors.

    abstract::Senescence represents a state of indefinite growth arrest in cells that have reached the end of their replicative life span, have become damaged, or express aberrant levels of cancer-related proteins. While senescence is widely considered to represent a tumor-suppressive mechanism, the accumulation of senescent cells ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Abdelmohsen K,Srikantan S,Kang MJ,Gorospe M

    更新日期:2012-09-01 00:00:00

  • Does cellular iron dysregulation play a causative role in Parkinson's disease?

    abstract::Selective dopaminergic cell loss in Parkinson's disease is correlated with increased levels of cellular iron. It is still hotly debated as to whether the increase in iron is an upstream event which acts to promote neurodegeneration via formation of oxidative stress or whether iron accumulates as a by-product of the ne...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Kaur D,Andersen J

    更新日期:2004-07-01 00:00:00

  • How bioinformatics can help reverse engineer human aging.

    abstract::To study human aging is an enormous challenge. The complexity of the aging phenotype and the near impossibility of studying aging directly in humans oblige researchers to resort to models and extrapolations. Computational approaches offer a powerful set of tools to study human aging. In one direction we have data-mini...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: de Magalhães JP,Toussaint O

    更新日期:2004-04-01 00:00:00

  • Ischemic preconditioning in the aging heart: from bench to bedside.

    abstract::Coronary artery disease is the leading cause of death in industrialized countries for people older than 65 years of age. The reasons are still unclear. A reduction of endogenous mechanisms against ischemic insults has been proposed to explain this phenomenon. Cardiac ischemic preconditioning represents the most powerf...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Abete P,Cacciatore F,Testa G,Della-Morte D,Galizia G,de Santis D,Calabrese C,Cioppa A,Ferrara N,Rengo F

    更新日期:2010-04-01 00:00:00

  • Auditory system dysfunction in Alzheimer disease and its prodromal states: A review.

    abstract::Recent findings suggest that both peripheral and central auditory system dysfunction occur in the prodromal stages of Alzheimer Disease (AD), and therefore may represent early indicators of the disease. In addition, loss of auditory function itself leads to communication difficulties, social isolation and poor quality...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Swords GM,Nguyen LT,Mudar RA,Llano DA

    更新日期:2018-07-01 00:00:00

  • Telomere transcription in ageing.

    abstract::Telomeres, the ends of eukaryotic chromosomes, play a central role in the control of cellular senescence and organismal ageing and need to be protected in order to avoid being recognised as damaged DNA and activate DNA damage response pathways. Dysfunctional telomeres arise from critically short telomeres or altered t...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Aguado J,d'Adda di Fagagna F,Wolvetang E

    更新日期:2020-09-01 00:00:00

  • The impact of cerebrovascular aging on vascular cognitive impairment and dementia.

    abstract::As human life expectancy rises, the aged population will increase. Aging is accompanied by changes in tissue structure, often resulting in functional decline. For example, aging within blood vessels contributes to a decrease in blood flow to important organs, potentially leading to organ atrophy and loss of function. ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Yang T,Sun Y,Lu Z,Leak RK,Zhang F

    更新日期:2017-03-01 00:00:00

  • Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.

    abstract::A wide array of cell signaling mediators and their interactions play vital roles in neuroinflammation associated with ischemia, brain trauma, developmental disorders and age-related neurodegeneration. Along with neurons, microglia and astrocytes are also affected by the inflammatory cascade by releasing pro-inflammato...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Rahimifard M,Maqbool F,Moeini-Nodeh S,Niaz K,Abdollahi M,Braidy N,Nabavi SM,Nabavi SF

    更新日期:2017-07-01 00:00:00

  • Lysines, Achilles' heel in alpha-synuclein conversion to a deadly neuronal endotoxin.

    abstract::Alpha-synuclein aggregation is associated with Parkinson's disease and other neurodegenerative disorders termed synucleinopathies. The sequence of alpha-synuclein has a remarkable amount of lysines, which may be a target for modifications by several aldehydes found at increased concentration in parkinsonian brains. Th...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Plotegher N,Bubacco L

    更新日期:2016-03-01 00:00:00

  • MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?

    abstract::The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Elliott ML

    更新日期:2020-08-01 00:00:00

  • The zebrafish as a gerontology model in nervous system aging, disease, and repair.

    abstract::Considering the increasing number of elderly in the world's population today, developing effective treatments for age-related pathologies is one of the biggest challenges in modern medical research. Age-related neurodegeneration, in particular, significantly impacts important sensory, motor, and cognitive functions, s...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Van Houcke J,De Groef L,Dekeyster E,Moons L

    更新日期:2015-11-01 00:00:00

  • Effect of soluble cleavage products of important receptors/ligands on efferocytosis: Their role in inflammatory, autoimmune and cardiovascular disease.

    abstract::Efferocytosis, the clearance of apoptotic cells (ACs), is a physiologic, multifaceted and dynamic process and a fundamental mechanism for the preservation of tissue homeostasis by avoiding unwanted inflammation and autoimmune responses through special phagocytic receptors. Defective efferocytosis is associated with sev...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Tajbakhsh A,Gheibi Hayat SM,Butler AE,Sahebkar A

    更新日期:2019-03-01 00:00:00

  • Pentraxins and Alzheimer's disease: at the interface between biomarkers and pharmacological targets.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder involving deposition of misfolded proteins in vulnerable brain regions leading to inexorable and progressive neuronal loss and deterioration of cognitive functions. The AD brain displays features typical of chronic inflammation as defined by the presence of acti...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Osera C,Pascale A,Amadio M,Venturini L,Govoni S,Ricevuti G

    更新日期:2012-04-01 00:00:00

  • Impact of aging on dendritic cell functions in humans.

    abstract::Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and phenotype of DC subset...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Agrawal A,Gupta S

    更新日期:2011-07-01 00:00:00

  • The impact of cognitive training and mental stimulation on cognitive and everyday functioning of healthy older adults: a systematic review and meta-analysis.

    abstract::This systematic review and meta-analysis investigates the impact of cognitive training and general mental stimulation on the cognitive and everyday functioning of older adults without known cognitive impairment. We examine transfer and maintenance of intervention effects, and the impact of training in group versus ind...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Kelly ME,Loughrey D,Lawlor BA,Robertson IH,Walsh C,Brennan S

    更新日期:2014-05-01 00:00:00

  • Autophagy in bone: Self-eating to stay in balance.

    abstract::Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight th...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Pierrefite-Carle V,Santucci-Darmanin S,Breuil V,Camuzard O,Carle GF

    更新日期:2015-11-01 00:00:00

  • LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging.

    abstract::Fibrosis is universally observed in multiple aging-related diseases and progressions and is characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various human organs and eventually results in organ failure. Noncoding RNAs (ncRNAs) have emerged as essential regulators of cellular signali...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Yang Z,Jiang S,Shang J,Jiang Y,Dai Y,Xu B,Yu Y,Liang Z,Yang Y

    更新日期:2019-07-01 00:00:00

  • Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation.

    abstract::Aging is the main risk factor contributing to vascular dysfunction and the progression of vascular diseases. In this review, we discuss the causes and mechanisms of vascular aging at the tissue and cellular level. We focus on Endothelial Cell (EC) and Smooth Muscle Cell (SMC) aging due to their critical role in mediat...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Mistriotis P,Andreadis ST

    更新日期:2017-08-01 00:00:00

  • Review of ICT-based services for identified unmet needs in people with dementia.

    abstract::Some of the needs that people with dementia and their informal carers currently perceive as insufficiently met by regular care and support services might be alleviated, or even be met, using modern Information and Communication Technology (ICT). The study described in this paper was designed to provide an insight into...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Lauriks S,Reinersmann A,Van der Roest HG,Meiland FJ,Davies RJ,Moelaert F,Mulvenna MD,Nugent CD,Dröes RM

    更新日期:2007-10-01 00:00:00

  • Sunlight and health: shifting the focus from vitamin D3 to photobiomodulation by red and near-infrared light.

    abstract::Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast bod...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Heiskanen V,Pfiffner M,Partonen T

    更新日期:2020-08-01 00:00:00

  • Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing.

    abstract::A-T is a prototype genome instability syndrome and a multifaceted disease. A-T leads to neurodegeneration - primarily cerebellar atrophy, immunodeficiency, oculocutaneous telangiectasia (dilated blood vessels), vestigial thymus and gonads, endocrine abnormalities, cancer predisposition and varying sensitivity to DNA d...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Shiloh Y,Lederman HM

    更新日期:2017-01-01 00:00:00