Abstract:
:The aging of the human adrenal cortex presents several problems of interest to the cell biologist, as the interplay of changes in growth, differentiation, apoptosis and cellular senescence affect the properties of the tissue over the life span. The human adrenal cortex also presents an interesting case of tumor progression, as nodules and adenomas are very common in aging, although carcinomas are rare. A specific puzzle for the gerontologist is the loss of biosynthesis of dehydroepiandrosterone (DHEA) and its sulfate by the human adrenal cortex in aging. The reason for the development of a specific zone of DHEA-secreting cells, the zona reticularis, in childhood and the later involution of this zone is completely unknown. This review explores these issues, the underlying basic cell and molecular biology, and the techniques that can address these questions.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Hornsby PJdoi
10.1016/s1568-1637(01)00007-1keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
229-42issue
2eissn
1568-1637issn
1872-9649pii
S1568163701000071journal_volume
1pub_type
杂志文章,评审abstract::The recent pandemics of the SARS-Cov-2 has pushed physical activity (PA) and exercise at the forefront of the discussion, since PA is associated with a reduced risk of developing all the chronic diseases strongly associated with severe cases of SARS-Cov-2 and exercise is considered a complimentary therapeutics for the...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2021.101258
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journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2011.11.002
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abstract::Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast bod...
journal_title:Ageing research reviews
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2016.09.008
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abstract::Functional activities of mature human neutrophils are strongly influenced by the pro-inflammatory cytokine granulocyte macrophage-colony stimulating factor (GM-CSF). Accordingly, a defective response to GM-CSF might have dramatic consequences for neutrophil functions and the host defence against infections. Such an ev...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2006.10.001
更新日期:2007-08-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2019.04.001
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101075
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101156
更新日期:2020-12-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2014.02.004
更新日期:2014-05-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2014.10.001
更新日期:2014-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.09.004
更新日期:2017-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.03.001
更新日期:2009-07-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.08.004
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Influenza vaccination is a simple strategy recommended for the prevention of influenza infection and its complications. This meta-analysis aimed to provide current supportive evidence for the breadth and validity of the observed protective effects of influenza vaccination on cardiovascular and respiratory ad...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101124
更新日期:2020-09-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101114
更新日期:2020-09-01 00:00:00
abstract::The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.01.001
更新日期:2018-03-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.06.001
更新日期:2017-08-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. ...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2013.12.007
更新日期:2014-05-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101115
更新日期:2020-09-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2006.03.007
更新日期:2006-05-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.04.001
更新日期:2018-07-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101149
更新日期:2020-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2019.100966
更新日期:2019-12-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101086
更新日期:2020-09-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2013.10.001
更新日期:2014-01-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2012.01.003
更新日期:2012-09-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2016.08.006
更新日期:2016-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101155
更新日期:2020-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2016.11.006
更新日期:2017-03-01 00:00:00
abstract::Alzheimer's disease (AD) is characterised by extracellular amyloid deposits, neurofibrillary tangles, synaptic loss, inflammation and extensive oxidative stress. Polyphenols, which include resveratrol, epigallocatechin gallate and curcumin, have gained considerable interest for their ability to reduce these hallmarks ...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2013.06.003
更新日期:2013-09-01 00:00:00