Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age.

Abstract:

:The development of clinical interventions that significantly improve human healthspan requires robust markers of biological age as well as thoughtful therapeutic targets. To promote these goals, we performed a systematic review and analysis of human aging and proteomics studies. The systematic review includes 36 different proteomics analyses, each of which identified proteins that significantly changed with age. We discovered 1,128 proteins that had been reported by at least two or more analyses and 32 proteins that had been reported by five or more analyses. Each of these 32 proteins has known connections relevant to aging and age-related disease. GDF15, for example, extends both lifespan and healthspan when overexpressed in mice and is additionally required for the anti-diabetic drug metformin to exert beneficial effects on body weight and energy balance. Bioinformatic enrichment analyses of our 1,128 commonly identified proteins heavily implicated processes relevant to inflammation, the extracellular matrix, and gene regulation. We additionally propose a novel proteomic aging clock comprised of proteins that were reported to change with age in plasma in three or more different studies. Using a large patient cohort comprised of 3,301 subjects (aged 18-76 years), we demonstrate that this clock is able to accurately predict human age.

journal_name

Ageing Res Rev

journal_title

Ageing research reviews

authors

Johnson AA,Shokhirev MN,Wyss-Coray T,Lehallier B

doi

10.1016/j.arr.2020.101070

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

101070

eissn

1568-1637

issn

1872-9649

pii

S1568-1637(20)30049-0

journal_volume

60

pub_type

杂志文章,meta分析
  • The eye as a model of ageing in translational research--molecular, epigenetic and clinical aspects.

    abstract::The eye and visual system are valuable in many areas of translational research such as stem cell therapy, transplantation research and gene therapy. Changes in many ocular tissues can be measured directly, easily and objectively in vivo (e.g. lens transparency; retinal blood vessel calibre; corneal endothelial cell co...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2012.11.002

    authors: Pathai S,Shiels PG,Lawn SD,Cook C,Gilbert C

    更新日期:2013-03-01 00:00:00

  • Autophagy in bone: Self-eating to stay in balance.

    abstract::Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight th...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2015.08.004

    authors: Pierrefite-Carle V,Santucci-Darmanin S,Breuil V,Camuzard O,Carle GF

    更新日期:2015-11-01 00:00:00

  • The emerging role of Wnt signaling dysregulation in the understanding and modification of age-associated diseases.

    abstract::Wnt signaling is a highly conserved pathway that participates in multiple aspects of cellular function during development and in adults. In particular, this pathway has been implicated in cell fate determination, proliferation and cell polarity establishment. In the brain, it contributes to synapse formation, axonal r...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2017.06.001

    authors: García-Velázquez L,Arias C

    更新日期:2017-08-01 00:00:00

  • Selective neuronal vulnerability in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is defined by a deficiency in specific behavioural and/or cognitive domains, pointing to selective vulnerabilities of specific neurons from different brain regions. These vulnerabilities can be compared across neuron subgroups to identify the most vulnerable neuronal types, regions, and time p...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101114

    authors: Wang ZT,Zhang C,Wang YJ,Dong Q,Tan L,Yu JT

    更新日期:2020-09-01 00:00:00

  • Cell-free microRNAs in Parkinson's disease: potential biomarkers that provide new insights into disease pathogenesis.

    abstract::MicroRNAs (miRNAs) are master post-transcriptional regulators of gene expression and their specific footprints reflect disease conditions. Over the last few years, several primary reports have described the deregulation of cell-free miRNAs in Parkinson's disease (PD), however, results have been rather inconsistent due...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101023

    authors: Doxakis E

    更新日期:2020-03-01 00:00:00

  • Exercise and skeletal muscle ageing: cellular and molecular mechanisms.

    abstract::As we age, our skeletal muscle becomes smaller and weaker. In addition, the remaining muscle is more susceptible to damage, particularly following exercise, recovery from damage is severely impaired and muscle is unable to adapt rapidly following sequential periods of exercise. The mechanisms by which skeletal muscle ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0047-6374(01)00368-2

    authors: McArdle A,Vasilaki A,Jackson M

    更新日期:2002-02-01 00:00:00

  • Genes, physical fitness and ageing.

    abstract::Persons aged 80 years and older are the fastest growing segment of the population. As more individuals live longer, we should try to understand the mechanisms involved in healthy ageing and preserving functional independence in later life. In elderly people, functional independence is directly dependent on physical fi...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2012.09.003

    authors: Garatachea N,Lucia A

    更新日期:2013-01-01 00:00:00

  • On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis.

    abstract::The amyloid cascade hypothesis, which implicates the amyloid Aβ peptide as the pathological initiator of both familial and sporadic, late onset Alzheimer's disease (AD), continues to guide the majority of research. We believe that current evidence does not support the amyloid cascade hypothesis for late onset AD. Inst...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2013.10.001

    authors: Castello MA,Soriano S

    更新日期:2014-01-01 00:00:00

  • Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation.

    abstract::A wide array of cell signaling mediators and their interactions play vital roles in neuroinflammation associated with ischemia, brain trauma, developmental disorders and age-related neurodegeneration. Along with neurons, microglia and astrocytes are also affected by the inflammatory cascade by releasing pro-inflammato...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2017.02.004

    authors: Rahimifard M,Maqbool F,Moeini-Nodeh S,Niaz K,Abdollahi M,Braidy N,Nabavi SM,Nabavi SF

    更新日期:2017-07-01 00:00:00

  • Revamping the evolutionary theories of aging.

    abstract::Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary theories of aging seek to explain why such stark longevity differences exist and why a deleterious process like aging evolved. The classical mutat...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.100947

    authors: Johnson AA,Shokhirev MN,Shoshitaishvili B

    更新日期:2019-11-01 00:00:00

  • How bioinformatics can help reverse engineer human aging.

    abstract::To study human aging is an enormous challenge. The complexity of the aging phenotype and the near impossibility of studying aging directly in humans oblige researchers to resort to models and extrapolations. Computational approaches offer a powerful set of tools to study human aging. In one direction we have data-mini...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2003.08.006

    authors: de Magalhães JP,Toussaint O

    更新日期:2004-04-01 00:00:00

  • Lysines, Achilles' heel in alpha-synuclein conversion to a deadly neuronal endotoxin.

    abstract::Alpha-synuclein aggregation is associated with Parkinson's disease and other neurodegenerative disorders termed synucleinopathies. The sequence of alpha-synuclein has a remarkable amount of lysines, which may be a target for modifications by several aldehydes found at increased concentration in parkinsonian brains. Th...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2015.12.002

    authors: Plotegher N,Bubacco L

    更新日期:2016-03-01 00:00:00

  • SIRT2: Controversy and multiple roles in disease and physiology.

    abstract::Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the cytoplasm but is also found in the mitochondria and in the nucleus. Recently, accumulating evidence has uncovered a growing number of...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.100961

    authors: Wang Y,Yang J,Hong T,Chen X,Cui L

    更新日期:2019-11-01 00:00:00

  • Telomere transcription in ageing.

    abstract::Telomeres, the ends of eukaryotic chromosomes, play a central role in the control of cellular senescence and organismal ageing and need to be protected in order to avoid being recognised as damaged DNA and activate DNA damage response pathways. Dysfunctional telomeres arise from critically short telomeres or altered t...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101115

    authors: Aguado J,d'Adda di Fagagna F,Wolvetang E

    更新日期:2020-09-01 00:00:00

  • Physical activity and exercise in the context of SARS-Cov-2: A perspective from geroscience field.

    abstract::The recent pandemics of the SARS-Cov-2 has pushed physical activity (PA) and exercise at the forefront of the discussion, since PA is associated with a reduced risk of developing all the chronic diseases strongly associated with severe cases of SARS-Cov-2 and exercise is considered a complimentary therapeutics for the...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2021.101258

    authors: de Souto Barreto P,Vellas B,Rolland Y

    更新日期:2021-01-12 00:00:00

  • Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?

    abstract::The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and a vascular disease in severe patients. The damage endothelial system provides a good explanat...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101201

    authors: Guan SP,Seet RCS,Kennedy BK

    更新日期:2020-12-01 00:00:00

  • Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing.

    abstract::Human ageing is associated with a gradual decline in the physiological functions of the body at multiple levels and it is a key risk factor for many diseases, including cancer. Ageing process is intimately related to widespread cellular senescence, characterised by an irreversible loss of proliferative capacity and al...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2015.03.004

    authors: Badiola I,Santaolalla F,Garcia-Gallastegui P,Ana SD,Unda F,Ibarretxe G

    更新日期:2015-09-01 00:00:00

  • Osteoclast motility: putting the brakes on bone resorption.

    abstract::As the skeleton ages, the balanced formation and resorption of normal bone remodeling is lost, and bone loss predominates. The osteoclast is the specialized cell that is responsible for bone resorption. It is a highly polarized cell that must adhere to the bone surface and migrate along it while resorbing, and cytoske...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2009.09.005

    authors: Novack DV,Faccio R

    更新日期:2011-01-01 00:00:00

  • The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging).

    abstract::Fighting the current COVID-19 pandemic, we must not forget to prepare for the next. Since elderly and frail people are at high risk, we wish to predict their vulnerability, and intervene if possible. For example, it would take little effort to take additional swabs or dried blood spots. Such minimally-invasive samplin...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101091

    authors: Fuellen G,Liesenfeld O,Kowald A,Barrantes I,Bastian M,Simm A,Jansen L,Tietz-Latza A,Quandt D,Franceschi C,Walter M

    更新日期:2020-09-01 00:00:00

  • Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing.

    abstract::A-T is a prototype genome instability syndrome and a multifaceted disease. A-T leads to neurodegeneration - primarily cerebellar atrophy, immunodeficiency, oculocutaneous telangiectasia (dilated blood vessels), vestigial thymus and gonads, endocrine abnormalities, cancer predisposition and varying sensitivity to DNA d...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2016.05.002

    authors: Shiloh Y,Lederman HM

    更新日期:2017-01-01 00:00:00

  • Designing neuroreparative strategies using aged regenerating animal models.

    abstract::In our ever-aging world population, the risk of age-related neuropathies has been increasing, representing both a social and economic burden to society. Since the ability to regenerate in the adult mammalian central nervous system is very limited, brain trauma and neurodegeneration are often permanent. As a consequenc...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101086

    authors: Vanhunsel S,Beckers A,Moons L

    更新日期:2020-09-01 00:00:00

  • Initiation of the age-related decline of odor identification in humans: A meta-analysis.

    abstract:BACKGROUND:Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent o...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.arr.2017.08.004

    authors: Zhang C,Wang X

    更新日期:2017-11-01 00:00:00

  • Does cellular iron dysregulation play a causative role in Parkinson's disease?

    abstract::Selective dopaminergic cell loss in Parkinson's disease is correlated with increased levels of cellular iron. It is still hotly debated as to whether the increase in iron is an upstream event which acts to promote neurodegeneration via formation of oxidative stress or whether iron accumulates as a by-product of the ne...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2004.01.003

    authors: Kaur D,Andersen J

    更新日期:2004-07-01 00:00:00

  • Bioenergetics of aging and calorie restriction.

    abstract::Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused o...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2006.03.006

    authors: Hunt ND,Hyun DH,Allard JS,Minor RK,Mattson MP,Ingram DK,de Cabo R

    更新日期:2006-05-01 00:00:00

  • Do not neglect the role of circadian rhythm in muscle atrophy.

    abstract::In addition to its role in movement, human skeletal muscle also plays important roles in physiological activities related to metabolism and the endocrine system. Aging and disease onset and progression can induce the reduction of skeletal muscle mass and function, thereby exacerbating skeletal muscle atrophy. Recent s...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101155

    authors: Zhang H,Liang J,Chen N

    更新日期:2020-11-01 00:00:00

  • Is Alzheimer's disease an inflammasomopathy?

    abstract::Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite the tremendous efforts researchers have put into AD research, there are no effective options for prevention and treatment of the disease. The best way to reach this goal is to clarify the mechanisms involved in the onset and progr...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.100966

    authors: Pereira CF,Santos AE,Moreira PI,Pereira AC,Sousa FJ,Cardoso SM,Cruz MT

    更新日期:2019-12-01 00:00:00

  • Cancer-free aging: Insights from Spalax ehrenbergi superspecies.

    abstract::Cancer and ageing can be regarded as two different manifestations of the same underlying process-accumulation of cellular damage-and therefore both are closely linked. Nowadays, the ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities, and therefore the understanding o...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2018.06.004

    authors: Lagunas-Rangel FA

    更新日期:2018-11-01 00:00:00

  • Use of near-infrared spectroscopy in the investigation of brain activation during cognitive aging: A systematic review of an emerging area of research.

    abstract::The cognitive neuroscience of aging is a growing and stimulating research area. The development of neuroimaging techniques in the past two decades has considerably increased our understanding of the brain mechanisms that might underlie cognitive performance and resulting changes due to normal aging. Beside traditional...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2017.07.003

    authors: Agbangla NF,Audiffren M,Albinet CT

    更新日期:2017-09-01 00:00:00

  • Aging: central role for autophagy and the lysosomal degradative system.

    abstract::The lysosomal network is the major intracellular proteolytic system accounting for more than 98% of long-lived bulk protein degradation and recycling particularly in tissues such as liver and muscles. Lysosomes are the final destination of intracellular damaged structures, identified and sequestered by the processes o...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2009.05.001

    authors: Rajawat YS,Hilioti Z,Bossis I

    更新日期:2009-07-01 00:00:00

  • Aging of the human adrenal cortex.

    abstract::The aging of the human adrenal cortex presents several problems of interest to the cell biologist, as the interplay of changes in growth, differentiation, apoptosis and cellular senescence affect the properties of the tissue over the life span. The human adrenal cortex also presents an interesting case of tumor progre...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s1568-1637(01)00007-1

    authors: Hornsby PJ

    更新日期:2002-04-01 00:00:00