Abstract:
:We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not require external sources of gases or complex technical equipment. Here, we showed for the first time that a chronic exposure of mice to HHE could be a unique tool for NMR-like metabolic remodeling, resulting in a long-term and substantial decrease in metabolic rate, body temperature, and food consumption, without significant changes in expression of stress-related genes. Unexpectedly, the HHE accelerated skin wound healing, despite the lower energy expenditure. The self-produced HHE could be considered a model of voluntary calorie restriction. All in all, a chronic exposure to HHE offers a potential of being a lifespan-extending intervention as well as an efficient tool for treating the overweight and associated metabolic disorders.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Tolstun DA,Knyazer A,Tushynska TV,Dubiley TA,Bezrukov VV,Fraifeld VE,Muradian KKdoi
10.1007/s10522-019-09848-9subject
Has Abstractpub_date
2020-04-01 00:00:00pages
143-153issue
2eissn
1389-5729issn
1573-6768pii
10.1007/s10522-019-09848-9journal_volume
21pub_type
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