Abstract:
:Aging is associated with accumulation of toxic intracellular and extracellular protein aggregates. Cells manage "aged" proteins by mobilizing their molecular chaperones or heat shock proteins that are also considered as determinants of lifespan in diverse species. In this study, we tested whether an exogenous addition of the non-toxic chemical chaperone 'glycerol' could elicit stress and geronto-protective activities. We found that glycerol enhanced chaperoning of heat-denatured proteins. In addition to stimulating proteasome activity, glycerol led to an increased expression of the stress chaperone 'mortalin' and decreased p53 function in human cells. Glycerol-fed worms exhibited thermo-tolerance and lower level of age-associated auto-fluorescence. Through the combined stimulation of the proteasome and chaperoning activities of mortalin, in particular, glycerol treatment resulted in increased survival and fitness against oxidative- and heat-stress. These results may have significant implications in the use of glycerol as a candidate geronto-modulator in development of practical interventions for "healthy aging".
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Deocaris CC,Takano S,Priyandoko D,Kaul Z,Yaguchi T,Kraft DC,Yamasaki K,Kaul SC,Wadhwa Rdoi
10.1007/s10522-008-9136-8subject
Has Abstractpub_date
2008-08-01 00:00:00pages
269-82issue
4eissn
1389-5729issn
1573-6768journal_volume
9pub_type
杂志文章相关文献
BIOGERONTOLOGY文献大全abstract::The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated b...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-7950-9
更新日期:2005-01-01 00:00:00
abstract::Besides epigenetic factors, the genetic make-up and differential gene expression not only determines aging and disease susceptibility but also the functional activity of cells in an individual. Analysis of a variety of mammalian tissues revealed that the age-associated differentially expressed genes mainly belong to i...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9094-6
更新日期:2007-10-01 00:00:00
abstract::An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-019-09801-w
更新日期:2019-06-01 00:00:00
abstract::In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade. Identifying and...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-014-9527-y
更新日期:2015-04-01 00:00:00
abstract::In this study, we have assessed the impact of vitamin E and exercise on acquisition and retention of spatial memory for a given task in aging rats, using a T-maze. Acetylcholine esterase (AChE) and cholineacetyl transferase (ChAT) activities and acetylcholine (ACh) were measured in the cerebral cortex (CC) of male Wis...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9154-6
更新日期:2009-02-01 00:00:00
abstract::Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9661-9
更新日期:2017-02-01 00:00:00
abstract::A reduced adaptation to cold is a prominent feature in aged mammals, including humans. The accelerated senescence-prone strain of mice (SAMP) has been studied as an animal model for several age-associated disorders and in the acceleration of senescence. Recent studies revealed that SAMP strains have dysfunctional hype...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-3499-x
更新日期:2005-01-01 00:00:00
abstract::We used the Fischer 344 rat as a model for aging effects on the heart. Cardiac interfibrillar mitochondria (IFM), located between the myofibrils, exhibit a decrease in protein yield and oxidative phosphorylation through complex III and IV in elderly (24 months) compared to adult controls (6 months). In contrast, subsa...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1015251212039
更新日期:2002-01-01 00:00:00
abstract::In order to know if insulin-like signalling is involved in the control of oxidative stress in mammalian tissues in relation to aging, ad libitum-fed and caloric restricted Wistar rats were treated during 2 weeks with GH and insulin. The most consistent effect of the hormonal treatments was an increase in plasma IGF-1 ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-004-7380-0
更新日期:2005-01-01 00:00:00
abstract::The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09867-x
更新日期:2020-06-01 00:00:00
abstract::Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9598-4
更新日期:2015-12-01 00:00:00
abstract::Cancers are different diseases that start and evolve each in its own manner, and trigger variable responses from the organism depending upon the neoplastic process under way and upon the physiopathology of the organism. The clinical incidence of the different cancers is spread through the human life span, with regiona...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1023/a:1011552822076
更新日期:2001-01-01 00:00:00
abstract::Oxidative stress caused by reactive oxygen species is proposed to cause age related muscle wasting (sarcopenia). Reversible oxidation of protein thiols by reactive oxygen species can affect protein function, so we evaluated whether muscle wasting in normal aging was associated with a pervasive increase in reversible o...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9483-y
更新日期:2014-02-01 00:00:00
abstract::When mortality (μ), aging rate (γ) and age (t) are treated according to the Gompertz model μ(t) = μ0eγt (GM), any mean age corresponds to a manifold of paired reciprocally changing μ0 and γ. Therefore, any noisiness of data used to derive GM parameters makes them negatively correlated. Besides this artifactual factor ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09828-z
更新日期:2019-12-01 00:00:00
abstract::Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and conditional effects of ge...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-015-9600-1
更新日期:2016-02-01 00:00:00
abstract::Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-020-09908-5
更新日期:2021-01-09 00:00:00
abstract::Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-017-9718-4
更新日期:2017-08-01 00:00:00
abstract::Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9316-1
更新日期:2011-04-01 00:00:00
abstract::Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-09793-z
更新日期:2019-04-01 00:00:00
abstract::Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09891-x
更新日期:2020-12-01 00:00:00
abstract::Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09796-4
更新日期:2019-06-01 00:00:00
abstract::The mutation level (chromosome aberrations covering telomere regions), modifications of chromosome structure (level of condensed chromatin identified by the methods of electron microscopy and differential scanning microcalorimetry; level of C-banding constitutive heterochromatin; transcriptional activity of DNA-depend...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1013266411263
更新日期:2001-01-01 00:00:00
abstract::eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not m...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1010029723081
更新日期:2000-01-01 00:00:00
abstract::Obesity is associated with functional limitations in muscle performance and increased likelihood of developing a functional disability such as mobility, strength, postural and dynamic balance limitations. The consensus is that obese individuals, regardless of age, have a greater absolute maximum muscle strength compar...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-015-9626-4
更新日期:2016-06-01 00:00:00
abstract::CD4+ T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4+ T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearanc...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-018-9754-8
更新日期:2018-12-01 00:00:00
abstract::Histone post-translational modifications (PTMs) are involved in diverse biological processes and methylation was regarded as a long-term epigenetic mark. Though aging represented one of the major risk factors for neurodegenerative diseases, no systematic investigations had correlated the patterns of histone PTMs in th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9231-5
更新日期:2010-02-01 00:00:00
abstract::Gene expression in aging kidney and pituitary was determined by subtractive hybridization, DNA microarrays and RT-PCR. Kidneys and pituitary were removed from 10- and 30-month-old female WAG/Rij rats, which were free from chronic progressive nephrosis and had a low incidence of pituitary tumors with age. From 350 cDNA...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/b:bgen.0000017685.91381.40
更新日期:2004-01-01 00:00:00
abstract::Drosophila melanogaster flies were exposed to hypergravity starting at two days of age, the range of gravity levels used being 2.58-7.38 g. No longevity change was observed for exposures of less than 14 days. The longevity of males increased if they were submitted to hypergravity for durations ranging from 14 to 24 da...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1010043914016
更新日期:2000-01-01 00:00:00
abstract::There is now a significant body of research that establishes the deceleration of mortality rates in late life and their ultimate leveling off on a late-life plateau. Natural selection has been offered as one mechanism responsible for these plateaus. The force of natural selection should also exert such effects on fema...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-006-9042-x
更新日期:2007-04-01 00:00:00
abstract::Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9425-8
更新日期:2013-06-01 00:00:00