Abstract:
:Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting hormesis through exposure to low-dose ionizing radiation (LDIR). Radiation-induced longevity hormesis has been repeatedly reported in invertebrate models such as C. elegans, Drosophila and flour beetles and in vertebrate models including guinea pigs, mice and rabbits. On the contrary, suppressing natural background radiation was repeatedly found to cause detrimental effects in protozoa, bacteria and flies. We also discussed here the possibility of clinical use of LDIR, predominantly for age-related disorders, e.g., Alzheimer's disease, for which no remedies are available. There is accumulating evidence that LDIR, such as those commonly used in X-ray imaging including computer tomography, might act as a hormetin. Of course, caution should be exercised when introducing new medical practices, and LDIR therapy is no exception. However, due to the low average residual life expectancy in old patients, the short-term benefits of such interventions (e.g., potential therapeutic effect against dementia) may outweigh their hypothetical delayed risks (e.g., cancer). We argue here that assessment and clinical trials of LDIR treatments should be given priority bearing in mind the enormous economic, social and ethical implications of potentially-treatable, age-related disorders.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Vaiserman A,Cuttler JM,Socol Ydoi
10.1007/s10522-020-09908-5subject
Has Abstractpub_date
2021-01-09 00:00:00eissn
1389-5729issn
1573-6768pii
10.1007/s10522-020-09908-5pub_type
杂志文章,评审相关文献
BIOGERONTOLOGY文献大全abstract::The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09867-x
更新日期:2020-06-01 00:00:00
abstract::The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9199-6
更新日期:2009-10-01 00:00:00
abstract::Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09796-4
更新日期:2019-06-01 00:00:00
abstract::Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-008-9131-0
更新日期:2008-08-01 00:00:00
abstract::The current linear no-threshold paradigm assumes that any exposure to ionizing radiation carries some risk, thus every effort should be made to maintain the exposures as low as possible. We examined whether background radiation impacts human longevity and cancer mortality. Our data covered the entire US population of ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09909-4
更新日期:2021-01-22 00:00:00
abstract::Ageing can have profound effects on the post-mitotic organ of behaviour, the brain. As yet the precise causes of these deleterious effects are unknown. However, clear insights into the putative mechanisms and consequences of ageing in the CNS have been achieved through the use of invertebrate models. It is now clear t...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1023/a:1011597420036
更新日期:2001-01-01 00:00:00
abstract::Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9316-1
更新日期:2011-04-01 00:00:00
abstract::Gene expression in aging kidney and pituitary was determined by subtractive hybridization, DNA microarrays and RT-PCR. Kidneys and pituitary were removed from 10- and 30-month-old female WAG/Rij rats, which were free from chronic progressive nephrosis and had a low incidence of pituitary tumors with age. From 350 cDNA...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/b:bgen.0000017685.91381.40
更新日期:2004-01-01 00:00:00
abstract::Behavioral symptoms of sickness, such as fever and motor activity are a coordinated set of changes that develop during infection. The aim of study was to compare the sickness behaviour (SB) in healthy old and young rats treated with pyrogenic dose of endotoxin and to check their glutathione level. Before experimentati...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9636-x
更新日期:2016-08-01 00:00:00
abstract::Aging process or senescence affects the expression of a wide range of phenotypic traits throughout the life span of organisms. These traits often show modular, synergistic, and even antagonistic relationships, and are also influenced by genomic, developmental, physiological and environmental factors. The cardiovascula...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9486-8
更新日期:2014-04-01 00:00:00
abstract::An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-019-09801-w
更新日期:2019-06-01 00:00:00
abstract::Oxidative damage has been proposed as an important factor in the progression of pathological and non-pathological age-related functional declines. Here, we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidant Manganese Superoxide Dismutase (Sod2). We find that the decline of s...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9210-2
更新日期:2009-10-01 00:00:00
abstract::Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9399-y
更新日期:2012-10-01 00:00:00
abstract::Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1015223917491
更新日期:2002-01-01 00:00:00
abstract::We studied vascular function in quiescent aortas from senescence-accelerated resistant (SAM-R1) and prone (SAM-P8) mice. Myographical studies of thoracic aorta segments from 6-7 month-old mice showed that the contractility of SAM-P8 aortas was markedly higher than that of SAM-R1 after KCl depolarization or phenylephri...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9108-4
更新日期:2007-12-01 00:00:00
abstract::Numerous reports implicate increased oxidative stress in the functional and structural changes occurring in the brain and other organs as a part of the normal aging process. Dietary restriction (DR) has long been shown to be life-prolonging intervention in several species. This study was aimed to assess the potential ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9240-4
更新日期:2010-04-01 00:00:00
abstract::Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer's, dialysis related amyloidosis (DRA), atherosclerosis and Parkinson's as well as physiological aging. This review attempts to summarize the data on glycation in relation...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-004-3189-0
更新日期:2004-01-01 00:00:00
abstract::A reduced adaptation to cold is a prominent feature in aged mammals, including humans. The accelerated senescence-prone strain of mice (SAMP) has been studied as an animal model for several age-associated disorders and in the acceleration of senescence. Recent studies revealed that SAMP strains have dysfunctional hype...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-3499-x
更新日期:2005-01-01 00:00:00
abstract::Changes in the levels of O-linked N-acetyl-glucosamine (O-GlcNAc) on nucleocytoplasmic protein have been associated with a number of age-related diseases such as Alzheimer's and diabetes; however, there is relatively little information regarding the impact of age on tissue O-GlcNAc levels. Therefore, the goal of this ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9123-5
更新日期:2008-06-01 00:00:00
abstract::Besides epigenetic factors, the genetic make-up and differential gene expression not only determines aging and disease susceptibility but also the functional activity of cells in an individual. Analysis of a variety of mammalian tissues revealed that the age-associated differentially expressed genes mainly belong to i...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9094-6
更新日期:2007-10-01 00:00:00
abstract::Oxidative stress caused by reactive oxygen species is proposed to cause age related muscle wasting (sarcopenia). Reversible oxidation of protein thiols by reactive oxygen species can affect protein function, so we evaluated whether muscle wasting in normal aging was associated with a pervasive increase in reversible o...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9483-y
更新日期:2014-02-01 00:00:00
abstract::eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not m...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1010029723081
更新日期:2000-01-01 00:00:00
abstract::Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9425-8
更新日期:2013-06-01 00:00:00
abstract::Accumulating studies have argued that the mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that promotes longevity in model organisms. In the present study, we screened an off-patent drug library to identify compounds that activate UPRmt using a mitochondrial chaperone hsp-6::GFP repo...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09907-6
更新日期:2021-02-01 00:00:00
abstract::Sarcopenia, characterized by profound muscle atrophy and the loss of contractile function, contributes significantly to the development of frailty and functional impairment in older age. Although present in aging humans, rat models have failed to clearly demonstrate a similar degree of this age-associated loss of musc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-4808-0
更新日期:2005-01-01 00:00:00
abstract::The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09861-3
更新日期:2020-06-01 00:00:00
abstract::The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9274-7
更新日期:2010-12-01 00:00:00
abstract::Age is the principal nonmodifiable risk factor for stroke. Over the past 10 years, suitable models for stroke in aged rats have been established. At genetic and cellular level there are significant differences in behavioral, cytological and genomics responses to injury in old animals as compared with the young ones. B...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9465-0
更新日期:2013-12-01 00:00:00
abstract::We used the Fischer 344 rat as a model for aging effects on the heart. Cardiac interfibrillar mitochondria (IFM), located between the myofibrils, exhibit a decrease in protein yield and oxidative phosphorylation through complex III and IV in elderly (24 months) compared to adult controls (6 months). In contrast, subsa...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1015251212039
更新日期:2002-01-01 00:00:00
abstract::Glycolysis and oxidative phosphorylation (OxPhos) are the two major mechanisms involved in brain energetics. In this article we propose that the sporadic forms of Alzheimer's disease (AD) are driven by age-related damage to macromolecules and organelles which results in the following series of dynamic processes. (1) M...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9403-6
更新日期:2012-12-01 00:00:00