Abstract：
:The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated by prolyl-4-hydroxylation. In human cells three closely related prolyl hydroxylases (PHDs) have been identified. An age-dependent decrease in HIF-1alpha expression was reported previously in brain, liver and kidney, which may be associated with a reduced adaptation to hypoxia as found in aged animals and humans. We have determined the expression of HIF-1alpha and the PHDs in human atrial trabeculae under normoxic and hypoxic conditions, in samples of human left ventricles as well as in heart extracts from female mice of different age (5 up to 16 months). With increasing age we found a decreased expression of HIF-1alpha, which correlated to an increased PHD3 expression in mouse and human heart. PHD3 was the most prominent HIF modifying hydroxylase found in human heart samples. Additionally, we found a strong ischemia/hypoxia-inducibility of PHD3 compared to PHD1 and PHD2 in atrial trabeculae. These data may explain the previously reported reduction of HIF-1alpha and HIF-1 target genes such as the vascular endothelial growth factor in ageing tissue.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Rohrbach S,Simm A,Pregla R,Franke C,Katschinski DMdoi
10.1007/s10522-005-7950-9keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
165-71issue
3eissn
1389-5729issn
1573-6768journal_volume
6pub_type
杂志文章相关文献
BIOGERONTOLOGY文献大全abstract：:Chronic oxidative stress plays a central role in the pathogenesis of many diseases, including HIV-1 associated disorders. Concomitantly with the decline of endogenous antioxidant systems, it was reported that HIV-1-related proteins increase the production of radical species in cells and tissues that are not directly i...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-014-9511-6
更新日期：2014-01-01 00:00:00
abstract：:Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9316-1
更新日期：2011-04-01 00:00:00
abstract：:For a period of 6-15 days prior to death, the fecundity and virility of Drosophila melanogaster fall significantly below those of same-aged flies that are not near death. It is likely that other aspects of physiology may decline during this period. This study attempts to document changes in two physiological character...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-012-9398-z
更新日期：2012-10-01 00:00:00
abstract：:Behavioral symptoms of sickness, such as fever and motor activity are a coordinated set of changes that develop during infection. The aim of study was to compare the sickness behaviour (SB) in healthy old and young rats treated with pyrogenic dose of endotoxin and to check their glutathione level. Before experimentati...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-016-9636-x
更新日期：2016-08-01 00:00:00
abstract：:Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in a...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-011-9343-6
更新日期：2011-12-01 00:00:00
abstract：:Melatonin synthesis is disordered in patients with Alzheimer's disease (AD). To determine the role of melatonin in the pathogenesis of AD, suitable animal models are needed. The OXYS rats are an experimental model of accelerated senescence that has also been proposed as a spontaneous rat model of AD-like pathology. In...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-014-9547-7
更新日期：2015-06-01 00:00:00
abstract：:The sample size of the data used in genetic studies is often a factor limiting the accuracy of statistical estimates. In this paper we suggest a new approach to evaluation of genetic influence on risk of development of aging-related health disorders. The approach results in substantial improvement of the accuracy of s...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-006-9072-4
更新日期：2007-06-01 00:00:00
abstract：:Hundreds of genes and miRNAs have been identified as being involved in the determination of longevity, aging patterns and in the development of age-related diseases (ARDs). The interplay between these genes as well as the role of miRNAs in the context of protein-protein interaction networks has as yet been poorly addr...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9265-8
更新日期：2010-08-01 00:00:00
abstract：:Sarcopenia, characterized by profound muscle atrophy and the loss of contractile function, contributes significantly to the development of frailty and functional impairment in older age. Although present in aging humans, rat models have failed to clearly demonstrate a similar degree of this age-associated loss of musc...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-005-4808-0
更新日期：2005-01-01 00:00:00
abstract：:Besides epigenetic factors, the genetic make-up and differential gene expression not only determines aging and disease susceptibility but also the functional activity of cells in an individual. Analysis of a variety of mammalian tissues revealed that the age-associated differentially expressed genes mainly belong to i...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-007-9094-6
更新日期：2007-10-01 00:00:00
abstract：:The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-020-09861-3
更新日期：2020-06-01 00:00:00
abstract：:Previously, extremely low, nanomolar concentrations of the mitochondria-targeted plastoquinone derivative SkQ1 (10-(6'-plastoquinonyl) decyltriphenylphosphonium) were shown to prolong the lifespan of male and female Drosophila melanogaster by about 10 % (Anisimov et al., Biochemistry (Moscow) 73:1329-1342, 2008). Usin...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-012-9404-5
更新日期：2012-12-01 00:00:00
abstract：:The long-term effects of X-irradiation with 0.25, 0.5, 0.75 and 1 Gy of 1 h eggs on the fitness-related life history traits in adult Drosophila melanogaster fruit flies and their offspring were investigated. Following irradiation with 0.25, 0.5 and 0.75 Gy, both F0 and F1 flies have decreased adult body weight and inc...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-004-2571-2
更新日期：2004-01-01 00:00:00
abstract：:The primary determinant of survival during aging is the energetic efficiency and metabolic stability required to counter the accumulated internal and external stresses of a lifetime. Hence, genetically stress-resistant individuals should accumulate with age; frailer, less robust, less energetically efficient and less ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-006-9064-4
更新日期：2007-04-01 00:00:00
abstract：:Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1023/a:1015236203379
更新日期：2002-01-01 00:00:00
abstract：:In the present study, we investigated whether the length of light/dark cycle could influence the pre-adult developmental time and adult life span in Drosophila melanogaster. Flies were reared to adulthood and maintained as adults under both 24-h (light/dark 12:12 h) and 48-h (light/dark 24:24 h) cycles. The flies rear...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9146-6
更新日期：2008-10-01 00:00:00
abstract：:Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (a...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9266-7
更新日期：2010-08-01 00:00:00
abstract：:FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malo...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-015-9611-y
更新日期：2016-04-01 00:00:00
abstract：:The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9274-7
更新日期：2010-12-01 00:00:00
abstract：:Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-016-9675-3
更新日期：2017-04-01 00:00:00
abstract：:Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bat...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-015-9592-x
更新日期：2015-12-01 00:00:00
abstract：:An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the maintenance of homeostasis due to various endogenous and environmental challenges, leading to amassing of damages, functional deterioration of ...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-016-9670-8
更新日期：2017-02-01 00:00:00
abstract：:Regular exercise is an important part of a healthy lifestyle, as it helps maintain a healthy weight and reduces the risk of chronic diseases. We explored the effects of lifelong exercise and aging on rat metabolism through a metabolomics approach. Thirty-six rats were divided into four equal groups: exercise during th...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-020-09871-1
更新日期：2020-10-01 00:00:00
abstract：:With advancing age, memory declines through different mechanisms including dysregulation of expression of synaptic plasticity genes in hippocampus. Increasing evidences suggest that these synaptic plasticity genes are regulated through epigenetic modifications. Recently we have reported that the neuronal immediate ear...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-019-09850-1
更新日期：2020-04-01 00:00:00
abstract：:The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9276-5
更新日期：2010-10-01 00:00:00
abstract：:When mortality (μ), aging rate (γ) and age (t) are treated according to the Gompertz model μ(t) = μ0eγt (GM), any mean age corresponds to a manifold of paired reciprocally changing μ0 and γ. Therefore, any noisiness of data used to derive GM parameters makes them negatively correlated. Besides this artifactual factor ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-019-09828-z
更新日期：2019-12-01 00:00:00
abstract：:Death-associated protein 6 (DAXX) is a ubiquitous protein implicated in various cellular processes such as apoptosis, tumorigenesis, development and transcription. The role of DAXX is however ambiguous and many contradictory results regarding its function in apoptosis upon various cellular stresses are described in th...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-016-9651-y
更新日期：2016-11-01 00:00:00
abstract：:Aging is associated with accumulation of toxic intracellular and extracellular protein aggregates. Cells manage "aged" proteins by mobilizing their molecular chaperones or heat shock proteins that are also considered as determinants of lifespan in diverse species. In this study, we tested whether an exogenous addition...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9136-8
更新日期：2008-08-01 00:00:00
abstract：:Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-016-9661-9
更新日期：2017-02-01 00:00:00
abstract：:In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade. Identifying and...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-014-9527-y
更新日期：2015-04-01 00:00:00
