Abstract:
:An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the maintenance of homeostasis due to various endogenous and environmental challenges, leading to amassing of damages, functional deterioration of different tissues and vulnerability to ailments. Nutrient sensing pathways that maintain glucose homeostasis in body are involved in regulation of aging. Insulin/insulin-like growth factor-1 (IGF-1) signalling (IIS) pathway was the first nutrient sensing pathway discovered to affect the aging process. This pathway is highly conserved and the most studied among different organisms. Epigenetic machineries that include DNA and histone modifying enzymes and various non-coding RNAs have been identified as important contributors to nutrition-related longevity and aging control. In this report, we present the homology and differences in IIS pathway of various organisms including worm, fly, rodent and human. We also discuss how epigenome remodelling, chromatin based strategies, small and long non-coding RNA are involved to regulate multiple steps of aging or age-related insulin homeostasis. Enhanced study of the role of IIS pathway and epigenetic mechanisms that regulate aging may facilitate progressive prevention and treatment of human age-related diseases.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Mathew R,Pal Bhadra M,Bhadra Udoi
10.1007/s10522-016-9670-8subject
Has Abstractpub_date
2017-02-01 00:00:00pages
35-53issue
1eissn
1389-5729issn
1573-6768pii
10.1007/s10522-016-9670-8journal_volume
18pub_type
杂志文章,评审相关文献
BIOGERONTOLOGY文献大全abstract::Accumulation of advanced glycation end products (AGEs) is accompanied by increased free radical activity which contributes to ageing and the development or worsening of degenerative diseases. Apart from other physiological factors, AGEs are also an important biomarker for premature ageing. Here we report protein modif...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-017-9733-5
更新日期:2018-02-01 00:00:00
abstract::The theory that accumulation of reactive oxygen species (ROS) in internal organs is a major promoter of aging has been considered negatively. However, it is still controversial whether overexpression of superoxide dismutases (SODs), which remove ROS, extends the lifespan in Drosophila adults. We examined whether ROS a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9570-3
更新日期:2015-08-01 00:00:00
abstract::With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotei...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-6039-9
更新日期:2006-04-01 00:00:00
abstract::eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not m...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1010029723081
更新日期:2000-01-01 00:00:00
abstract::Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9598-4
更新日期:2015-12-01 00:00:00
abstract::Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-008-9131-0
更新日期:2008-08-01 00:00:00
abstract::The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9199-6
更新日期:2009-10-01 00:00:00
abstract::In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to s...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-018-9748-6
更新日期:2018-07-01 00:00:00
abstract::Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9139-5
更新日期:2008-10-01 00:00:00
abstract::Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1015223917491
更新日期:2002-01-01 00:00:00
abstract::Hundreds of genes and miRNAs have been identified as being involved in the determination of longevity, aging patterns and in the development of age-related diseases (ARDs). The interplay between these genes as well as the role of miRNAs in the context of protein-protein interaction networks has as yet been poorly addr...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9265-8
更新日期:2010-08-01 00:00:00
abstract::The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated b...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-7950-9
更新日期:2005-01-01 00:00:00
abstract::It has been postulated that the presence of parasites causing high extrinsic mortality may trigger an inducible acceleration of the host aging. We tested this hypothesis using isogenic populations of Caenorhabditis elegans nematodes and different Escherichia coli strains. When exposed to pathogenic bacteria, nematodes...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9228-0
更新日期:2010-02-01 00:00:00
abstract::A reduced adaptation to cold is a prominent feature in aged mammals, including humans. The accelerated senescence-prone strain of mice (SAMP) has been studied as an animal model for several age-associated disorders and in the acceleration of senescence. Recent studies revealed that SAMP strains have dysfunctional hype...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-3499-x
更新日期:2005-01-01 00:00:00
abstract::Menopause marks the end of the reproductive life span of women and is characterized by a dramatic drop of circulating estrogen. Hormone replacement therapy (HRT) has been successfully used to treat the symptoms of menopause because estrogen has strong suppressive effects on climacteric complaints. As the hypothalamo-p...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-2623-2
更新日期:2005-01-01 00:00:00
abstract::During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1023/a:1010004901256
更新日期:2001-01-01 00:00:00
abstract::Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-017-9711-y
更新日期:2017-08-01 00:00:00
abstract::Glycolysis and oxidative phosphorylation (OxPhos) are the two major mechanisms involved in brain energetics. In this article we propose that the sporadic forms of Alzheimer's disease (AD) are driven by age-related damage to macromolecules and organelles which results in the following series of dynamic processes. (1) M...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9403-6
更新日期:2012-12-01 00:00:00
abstract::Previously, extremely low, nanomolar concentrations of the mitochondria-targeted plastoquinone derivative SkQ1 (10-(6'-plastoquinonyl) decyltriphenylphosphonium) were shown to prolong the lifespan of male and female Drosophila melanogaster by about 10 % (Anisimov et al., Biochemistry (Moscow) 73:1329-1342, 2008). Usin...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9404-5
更新日期:2012-12-01 00:00:00
abstract::Obesity is associated with functional limitations in muscle performance and increased likelihood of developing a functional disability such as mobility, strength, postural and dynamic balance limitations. The consensus is that obese individuals, regardless of age, have a greater absolute maximum muscle strength compar...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-015-9626-4
更新日期:2016-06-01 00:00:00
abstract::Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9787-z
更新日期:2019-04-01 00:00:00
abstract::In order to know if insulin-like signalling is involved in the control of oxidative stress in mammalian tissues in relation to aging, ad libitum-fed and caloric restricted Wistar rats were treated during 2 weeks with GH and insulin. The most consistent effect of the hormonal treatments was an increase in plasma IGF-1 ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-004-7380-0
更新日期:2005-01-01 00:00:00
abstract::There is increasing support for the notion that genetic variation for lifespan, both within and between species, is correlated with variation in the efficiency of the free radical scavenging system and the ability to withstand oxidative stress. In Drosophila, resistance to dietary paraquat, a free radical generator, i...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-4903-2
更新日期:2005-12-01 00:00:00
abstract::We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09848-9
更新日期:2020-04-01 00:00:00
abstract::Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-020-09908-5
更新日期:2021-01-09 00:00:00
abstract::Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-09793-z
更新日期:2019-04-01 00:00:00
abstract::Regular exercise is an important part of a healthy lifestyle, as it helps maintain a healthy weight and reduces the risk of chronic diseases. We explored the effects of lifelong exercise and aging on rat metabolism through a metabolomics approach. Thirty-six rats were divided into four equal groups: exercise during th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09871-1
更新日期:2020-10-01 00:00:00
abstract::Two sibling Drosophila species dramatically divergent in longevity, Drosophila buzzatii and D. koepferae, were examined for possible effects of both developmental culture medium and dietary composition (DC) on longevity. Longevity was greatly increased in the longer lived D. buzzatii when flies were reared and fed on ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9441-8
更新日期:2013-08-01 00:00:00
abstract::In mammals suprachiasmatic nucleus (SCN), acts as a light entrainable master clock and by generation of temporal oscillations regulates the peripheral organs acting as autonomous clocks resulting in overt behavioral and physiological rhythms. SCN also controls synthesis and release of melatonin (hormonal message for d...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9656-6
更新日期:2016-11-01 00:00:00
abstract::Adult stem cells are known to have a finite replication potential. Muscle biopsy-derived human satellite cells (SCs) were grown at different passages and differentiated to human myotubes in culture to analyze the functional state of various carbohydrate and lipid metabolic pathways. As the proliferative potential of m...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-011-9336-5
更新日期:2011-08-01 00:00:00