Survival and longevity improvements at extreme ages: an interpretation assuming an ecological stress theory of aging.

abstract：:The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...

journal_title：Biogerontology

authors： Kumar R,Sharma A,Padwad Y,Sharma R

更新日期：2020-06-01 00:00:00

abstract：:Sarcopenia, defined as the age-related loss of muscle mass, subsequently has a negative effect on strength, metabolic rate and functionality leading to a reduced quality of life. With the projected increase in life expectancy, the incidence of muscle loss may rise and further drain the health care system, with greater...

journal_title：Biogerontology

authors： Candow DG

更新日期：2011-08-01 00:00:00

abstract：:Cancers are different diseases that start and evolve each in its own manner, and trigger variable responses from the organism depending upon the neoplastic process under way and upon the physiopathology of the organism. The clinical incidence of the different cancers is spread through the human life span, with regiona...

journal_title：Biogerontology

authors： Macieira-Coelho A

更新日期：2001-01-01 00:00:00

abstract：:Gene expression in aging kidney and pituitary was determined by subtractive hybridization, DNA microarrays and RT-PCR. Kidneys and pituitary were removed from 10- and 30-month-old female WAG/Rij rats, which were free from chronic progressive nephrosis and had a low incidence of pituitary tumors with age. From 350 cDNA...

journal_title：Biogerontology

authors： Preisser L,Houot L,Teillet L,Kortulewski T,Morel A,Tronik-Le Roux D,Corman B

更新日期：2004-01-01 00:00:00

abstract：:Numerous reports implicate increased oxidative stress in the functional and structural changes occurring in the brain and other organs as a part of the normal aging process. Dietary restriction (DR) has long been shown to be life-prolonging intervention in several species. This study was aimed to assess the potential ...

journal_title：Biogerontology

authors： Sharma S,Singh R,Kaur M,Kaur G

更新日期：2010-04-01 00:00:00

abstract：:An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the maintenance of homeostasis due to various endogenous and environmental challenges, leading to amassing of damages, functional deterioration of ...

journal_title：Biogerontology

authors： Mathew R,Pal Bhadra M,Bhadra U

更新日期：2017-02-01 00:00:00

abstract：:Oxidative damage has been proposed as an important factor in the progression of pathological and non-pathological age-related functional declines. Here, we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidant Manganese Superoxide Dismutase (Sod2). We find that the decline of s...

journal_title：Biogerontology

authors： Piazza N,Hayes M,Martin I,Duttaroy A,Grotewiel M,Wessells R

更新日期：2009-10-01 00:00:00

abstract：:Longevity is mainly conditioned by genetic, epigenetic and environmental factors. Different genetic modifications seem to be positively associated to longevity, including SNPs in SIRT1, APOE, FOXO3A, ACE, ATM, NOS1 and NOS2 gene. Epigenetic changes as DNA hyper- and hypo-methylation influence significantly human longe...

journal_title：Biogerontology

authors： Costa D,Scognamiglio M,Fiorito C,Benincasa G,Napoli C

更新日期：2019-10-01 00:00:00

abstract：:Ageing can have profound effects on the post-mitotic organ of behaviour, the brain. As yet the precise causes of these deleterious effects are unknown. However, clear insights into the putative mechanisms and consequences of ageing in the CNS have been achieved through the use of invertebrate models. It is now clear t...

journal_title：Biogerontology

authors： Yeoman MS,Faragher RG

更新日期：2001-01-01 00:00:00

abstract：:The theory that accumulation of reactive oxygen species (ROS) in internal organs is a major promoter of aging has been considered negatively. However, it is still controversial whether overexpression of superoxide dismutases (SODs), which remove ROS, extends the lifespan in Drosophila adults. We examined whether ROS a...

journal_title：Biogerontology

authors： Oka S,Hirai J,Yasukawa T,Nakahara Y,Inoue YH

更新日期：2015-08-01 00:00:00

abstract：:Hundreds of genes and miRNAs have been identified as being involved in the determination of longevity, aging patterns and in the development of age-related diseases (ARDs). The interplay between these genes as well as the role of miRNAs in the context of protein-protein interaction networks has as yet been poorly addr...

journal_title：Biogerontology

authors： Tacutu R,Budovsky A,Fraifeld VE

更新日期：2010-08-01 00:00:00

abstract：:Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...

journal_title：Biogerontology

authors： Hasan AU,Ohmori K,Hashimoto T,Kamitori K,Yamaguchi F,Konishi K,Noma T,Igarashi J,Yamashita T,Hirano K,Tokuda M,Minamino T,Nishiyama A,Kohno M

更新日期：2017-02-01 00:00:00

abstract：:There is a viewpoint that suppression of the proliferative capacity of cells and impairment of the regeneration of tissues and organs in aging are a consequence of specially arisen during evolution mechanisms that reduce the risk of malignant transformation and, thus, protect against cancer. We believe that the restri...

journal_title：Biogerontology

authors： Khokhlov AN

更新日期：2013-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) are formed by all aerobic organisms, and are involved in the numerous physiological and pathophysiological processes. Opioid peptides belong to a class of bioactive compounds of great interest because of their opiate-like activity. We determined the influence of methionine-enkephalin (MEN...

journal_title：Biogerontology

authors： Sobocanec S,Kusić B,Sverko V,Balog T,Marotti T

更新日期：2006-02-01 00:00:00

abstract：:Oxidative stress caused by reactive oxygen species is proposed to cause age related muscle wasting (sarcopenia). Reversible oxidation of protein thiols by reactive oxygen species can affect protein function, so we evaluated whether muscle wasting in normal aging was associated with a pervasive increase in reversible o...

journal_title：Biogerontology

authors： Tohma H,El-Shafey AF,Croft K,Shavlakadze T,Grounds MD,Arthur PG

更新日期：2014-02-01 00:00:00

abstract：:Adult stem cells are known to have a finite replication potential. Muscle biopsy-derived human satellite cells (SCs) were grown at different passages and differentiated to human myotubes in culture to analyze the functional state of various carbohydrate and lipid metabolic pathways. As the proliferative potential of m...

journal_title：Biogerontology

authors： Nehlin JO,Just M,Rustan AC,Gaster M

更新日期：2011-08-01 00:00:00

abstract：:For a period of 6-15 days prior to death, the fecundity and virility of Drosophila melanogaster fall significantly below those of same-aged flies that are not near death. It is likely that other aspects of physiology may decline during this period. This study attempts to document changes in two physiological character...

journal_title：Biogerontology

authors： Shahrestani P,Tran X,Mueller LD

更新日期：2012-10-01 00:00:00

abstract：:Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and conditional effects of ge...

journal_title：Biogerontology

authors： Ukraintseva S,Yashin A,Arbeev K,Kulminski A,Akushevich I,Wu D,Joshi G,Land KC,Stallard E

更新日期：2016-02-01 00:00:00

abstract：:The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by ...

journal_title：Biogerontology

authors： Pietsch K,Saul N,Menzel R,Stürzenbaum SR,Steinberg CE

更新日期：2009-10-01 00:00:00

abstract：:Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bat...

journal_title：Biogerontology

authors： Novikov E,Kondratyuk E,Petrovski D,Titova T,Zadubrovskaya I,Zadubrovskiy P,Moshkin M

更新日期：2015-12-01 00:00:00

abstract：:Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...

journal_title：Biogerontology

authors： Augustyniak J,Lenart J,Zychowicz M,Stepien PP,Buzanska L

更新日期：2017-08-01 00:00:00

abstract：:In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to s...

journal_title：Biogerontology

authors： Zole E,Ranka R

更新日期：2018-07-01 00:00:00

abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a de novo genetic mutation that leads to the accumulation of a splicing isoform of lamin A termed progerin. Progerin expression alters the organization of the nuclear lamina and chromatin. The life expectancy of HGPS patients is severe...

journal_title：Biogerontology

authors： Brassard JA,Fekete N,Garnier A,Hoesli CA

更新日期：2016-02-01 00:00:00

abstract：:Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...

journal_title：Biogerontology

authors： Wensink M

更新日期：2013-02-01 00:00:00

abstract：:Adipose tissue plays a pivotal role in ageing and longevity; many studies, both human and animal, have focussed on the effects of food limitation. Here we present a new model based on striking differences between two 'normal' inbred strains of albino Wistar rats the Charles River (CR) and Harlan Olac (HO) that have ma...

journal_title：Biogerontology

authors： Kunjara S,Greenbaum AL,Rademacher TW,McLean P

更新日期：2010-08-01 00:00:00

abstract：:There is increasing support for the notion that genetic variation for lifespan, both within and between species, is correlated with variation in the efficiency of the free radical scavenging system and the ability to withstand oxidative stress. In Drosophila, resistance to dietary paraquat, a free radical generator, i...

journal_title：Biogerontology

authors： Vermeulen CJ,Van De Zande L,Bijlsma R

更新日期：2005-12-01 00:00:00

abstract：:The sample size of the data used in genetic studies is often a factor limiting the accuracy of statistical estimates. In this paper we suggest a new approach to evaluation of genetic influence on risk of development of aging-related health disorders. The approach results in substantial improvement of the accuracy of s...

journal_title：Biogerontology

authors： Yashin AI,Arbeev KG,Ukraintseva SV

更新日期：2007-06-01 00:00:00

abstract：:In mammals suprachiasmatic nucleus (SCN), acts as a light entrainable master clock and by generation of temporal oscillations regulates the peripheral organs acting as autonomous clocks resulting in overt behavioral and physiological rhythms. SCN also controls synthesis and release of melatonin (hormonal message for d...

journal_title：Biogerontology

authors： Vinod C,Jagota A

更新日期：2016-11-01 00:00:00

abstract：:Prophylaxis with vaccines is important in geriatrics as, apart from specific protection, it reduces incidence of potentially fatal infectious complications and exacerbations of existing medical conditions. Post-vaccination protection depends on immunity and therefore markers of immune status could be used to predict e...

journal_title：Biogerontology

authors： Trzonkowski P,Myśliwska J,Pawelec G,Myśliwski A

更新日期：2009-02-01 00:00:00

abstract：:The predominant molecular symptom of ageing is the accumulation of altered gene products. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin activity. P...

journal_title：Biogerontology

authors： Hipkiss AR

更新日期：2008-02-01 00:00:00