The accuracy of statistical estimates in genetic studies of aging can be significantly improved.

abstract：:The effects of oxidative stress (OS) on the rat erythrocytes (RBCs) that were fractionated on the percoll/BSA gradient into young and old cells were studied to find out if the altered Na+/H+ and Cl⁻/ HCO3⁻ antiporters and in turn the intracellular pH (pHi) could act as one of the promoters of cell death. Old cells wer...

journal_title：Biogerontology

authors： Asha Devi S,Shiva Shankar Reddy CS,Subramanyam MV

更新日期：2009-12-01 00:00:00

abstract：:Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...

journal_title：Biogerontology

authors： Arbeev KG,Ukraintseva SV,Arbeeva LS,Akushevich I,Kulminski AM,Yashin AI

更新日期：2011-04-01 00:00:00

abstract：:The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated b...

journal_title：Biogerontology

authors： Rohrbach S,Simm A,Pregla R,Franke C,Katschinski DM

更新日期：2005-01-01 00:00:00

abstract：:It is known that a global decrease in food ingestion (dietary restriction, DR) lowers mitochondrial ROS generation (mitROS) and oxidative stress in young immature rats. This seems to be caused by the decreased methionine ingestion of DR animals. This is interesting since isocaloric methionine restriction in the diet (...

journal_title：Biogerontology

authors： Sanchez-Roman I,Gómez A,Pérez I,Sanchez C,Suarez H,Naudí A,Jové M,Lopez-Torres M,Pamplona R,Barja G

更新日期：2012-08-01 00:00:00

abstract：:High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complex...

journal_title：Biogerontology

authors： Ezcurra M

更新日期：2018-12-01 00:00:00

abstract：:Changes in the levels of O-linked N-acetyl-glucosamine (O-GlcNAc) on nucleocytoplasmic protein have been associated with a number of age-related diseases such as Alzheimer's and diabetes; however, there is relatively little information regarding the impact of age on tissue O-GlcNAc levels. Therefore, the goal of this ...

journal_title：Biogerontology

authors： Fülöp N,Feng W,Xing D,He K,Nőt LG,Brocks CA,Marchase RB,Miller AP,Chatham JC

更新日期：2008-06-01 00:00:00

abstract：:We propose a "protein and energy" free radical model of aging that predicts patterns of survival and fertility curves for Mediterranean fruit flies. Mathematical and simulation models of individual physiological processes were constructed in terms of stochastic differential equations. The free radical theory of aging ...

journal_title：Biogerontology

authors： Butov AA,Carey JR,Volkov MA,Sehl ME,Yashin AI

更新日期：2003-01-01 00:00:00

abstract：:Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bat...

journal_title：Biogerontology

authors： Novikov E,Kondratyuk E,Petrovski D,Titova T,Zadubrovskaya I,Zadubrovskiy P,Moshkin M

更新日期：2015-12-01 00:00:00

abstract：:Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...

journal_title：Biogerontology

authors： Jagota A,Mattam U

更新日期：2017-08-01 00:00:00

abstract：:Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...

journal_title：Biogerontology

authors： Ito Y,Betsuyaku T,Moriyama C,Nasuhara Y,Nishimura M

更新日期：2009-04-01 00:00:00

abstract：:Adult stem cells are known to have a finite replication potential. Muscle biopsy-derived human satellite cells (SCs) were grown at different passages and differentiated to human myotubes in culture to analyze the functional state of various carbohydrate and lipid metabolic pathways. As the proliferative potential of m...

journal_title：Biogerontology

authors： Nehlin JO,Just M,Rustan AC,Gaster M

更新日期：2011-08-01 00:00:00

abstract：:The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...

journal_title：Biogerontology

authors： Mocchegiani E,Basso A,Giacconi R,Piacenza F,Costarelli L,Pierpaoli S,Malavolta M

更新日期：2010-10-01 00:00:00

abstract：:In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to s...

journal_title：Biogerontology

authors： Zole E,Ranka R

更新日期：2018-07-01 00:00:00

abstract：:During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...

journal_title：Biogerontology

authors： Holliday R

更新日期：2001-01-01 00:00:00

abstract：:Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in a...

journal_title：Biogerontology

authors： Yang LW,Song M,Li YL,Liu YP,Liu C,Han L,Wang ZH,Zhang W,Xing YQ,Zhong M

更新日期：2019-04-01 00:00:00

abstract：:An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...

journal_title：Biogerontology

authors： Xia J,Gravato-Nobre M,Ligoxygakis P

更新日期：2019-06-01 00:00:00

abstract：:Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related diseases in many organisms including humans. The present study aimed to examine the influence of long-term DR on the BDNF system at the transcriptional and translational levels in the cortex and hippocampus of middle-aged ...

journal_title：Biogerontology

authors： Smiljanic K,Pesic V,Mladenovic Djordjevic A,Pavkovic Z,Brkic M,Ruzdijic S,Kanazir S

更新日期：2015-02-01 00:00:00

abstract：:Gene expression in aging kidney and pituitary was determined by subtractive hybridization, DNA microarrays and RT-PCR. Kidneys and pituitary were removed from 10- and 30-month-old female WAG/Rij rats, which were free from chronic progressive nephrosis and had a low incidence of pituitary tumors with age. From 350 cDNA...

journal_title：Biogerontology

authors： Preisser L,Houot L,Teillet L,Kortulewski T,Morel A,Tronik-Le Roux D,Corman B

更新日期：2004-01-01 00:00:00

abstract：:With advancing age, memory declines through different mechanisms including dysregulation of expression of synaptic plasticity genes in hippocampus. Increasing evidences suggest that these synaptic plasticity genes are regulated through epigenetic modifications. Recently we have reported that the neuronal immediate ear...

journal_title：Biogerontology

authors： Kushwaha A,Thakur MK

更新日期：2020-04-01 00:00:00

abstract：:The current linear no-threshold paradigm assumes that any exposure to ionizing radiation carries some risk, thus every effort should be made to maintain the exposures as low as possible. We examined whether background radiation impacts human longevity and cancer mortality. Our data covered the entire US population of ...

journal_title：Biogerontology

authors： David E,Wolfson M,Fraifeld VE

更新日期：2021-01-22 00:00:00

abstract：:Aging is associated with accumulation of toxic intracellular and extracellular protein aggregates. Cells manage "aged" proteins by mobilizing their molecular chaperones or heat shock proteins that are also considered as determinants of lifespan in diverse species. In this study, we tested whether an exogenous addition...

journal_title：Biogerontology

authors： Deocaris CC,Takano S,Priyandoko D,Kaul Z,Yaguchi T,Kraft DC,Yamasaki K,Kaul SC,Wadhwa R

更新日期：2008-08-01 00:00:00

abstract：:Besides epigenetic factors, the genetic make-up and differential gene expression not only determines aging and disease susceptibility but also the functional activity of cells in an individual. Analysis of a variety of mammalian tissues revealed that the age-associated differentially expressed genes mainly belong to i...

journal_title：Biogerontology

authors： Panda H,Pandey RS,Debata PR,Supakar PC

更新日期：2007-10-01 00:00:00

abstract：:Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...

journal_title：Biogerontology

authors： Vaiserman A,Cuttler JM,Socol Y

更新日期：2021-01-09 00:00:00

abstract：:Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...

journal_title：Biogerontology

authors： Sipilä S,Narici M,Kjaer M,Pöllänen E,Atkinson RA,Hansen M,Kovanen V

更新日期：2013-06-01 00:00:00

abstract：:During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...

journal_title：Biogerontology

authors： Böttner M,Leonhardt S,Wuttke W,Wedel T,Jarry H

更新日期：2010-02-01 00:00:00

abstract：:Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...

journal_title：Biogerontology

authors： Witham MD

更新日期：2019-04-01 00:00:00

abstract：:Histone post-translational modifications (PTMs) are involved in diverse biological processes and methylation was regarded as a long-term epigenetic mark. Though aging represented one of the major risk factors for neurodegenerative diseases, no systematic investigations had correlated the patterns of histone PTMs in th...

journal_title：Biogerontology

authors： Wang CM,Tsai SN,Yew TW,Kwan YW,Ngai SM

更新日期：2010-02-01 00:00:00

abstract：:In the present study, we investigated whether the length of light/dark cycle could influence the pre-adult developmental time and adult life span in Drosophila melanogaster. Flies were reared to adulthood and maintained as adults under both 24-h (light/dark 12:12 h) and 48-h (light/dark 24:24 h) cycles. The flies rear...

journal_title：Biogerontology

authors： Vaiserman AM,Pisaruck AV,Timchenko AN,Voitenko VP,Koshel NM,Grigoriev PE

更新日期：2008-10-01 00:00:00

abstract：:Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in a...

journal_title：Biogerontology

authors： Yanai H,Budovsky A,Tacutu R,Fraifeld VE

更新日期：2011-12-01 00:00:00

abstract：:Regular exercise is an important part of a healthy lifestyle, as it helps maintain a healthy weight and reduces the risk of chronic diseases. We explored the effects of lifelong exercise and aging on rat metabolism through a metabolomics approach. Thirty-six rats were divided into four equal groups: exercise during th...

journal_title：Biogerontology

authors： Tzimou A,Benaki D,Nikolaidis S,Mikros E,Taitzoglou I,Mougios V

更新日期：2020-10-01 00:00:00