Abstract:
:High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complexity and heterogeneity of the human microbiome we need robust experimental models that allow the systematic manipulation of variables to test the multitude of hypotheses arisen from large-scale 'meta-omic' projects. The nematode C. elegans combined with bacterial models offers an avenue to dissect cause and effect in host-microbiome interactions. This combined model allows the genetic manipulation of both host and microbial genetics and the use of a variety of tools, to identify pathways affecting host health. A number of recent high impact studies have used C. elegans to identify microbial pathways affecting ageing and longevity, demonstrating the power of the combined C. elegans-bacterial model. Here I will review the current state of the field, what we have learned from using C. elegans to study gut microbiome and host interactions, and the potential of using this model system in the future.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Ezcurra Mdoi
10.1007/s10522-018-9752-xsubject
Has Abstractpub_date
2018-12-01 00:00:00pages
567-578issue
6eissn
1389-5729issn
1573-6768pii
10.1007/s10522-018-9752-xjournal_volume
19pub_type
杂志文章相关文献
BIOGERONTOLOGY文献大全abstract::Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9316-1
更新日期:2011-04-01 00:00:00
abstract::After reaching adulthood, orderly repair is probably one of the most important mechanisms throughout lifetime. Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development. Organ failure in the ageing organism...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9453-4
更新日期:2013-12-01 00:00:00
abstract::The predominant molecular symptom of ageing is the accumulation of altered gene products. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin activity. P...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9110-x
更新日期:2008-02-01 00:00:00
abstract::The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9276-5
更新日期:2010-10-01 00:00:00
abstract::In the present study, we investigated whether the length of light/dark cycle could influence the pre-adult developmental time and adult life span in Drosophila melanogaster. Flies were reared to adulthood and maintained as adults under both 24-h (light/dark 12:12 h) and 48-h (light/dark 24:24 h) cycles. The flies rear...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9146-6
更新日期:2008-10-01 00:00:00
abstract::In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescen...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9767-3
更新日期:2018-10-01 00:00:00
abstract::There is now a significant body of research that establishes the deceleration of mortality rates in late life and their ultimate leveling off on a late-life plateau. Natural selection has been offered as one mechanism responsible for these plateaus. The force of natural selection should also exert such effects on fema...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-006-9042-x
更新日期:2007-04-01 00:00:00
abstract::During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9230-6
更新日期:2010-02-01 00:00:00
abstract::Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1015236203379
更新日期:2002-01-01 00:00:00
abstract::We propose a "protein and energy" free radical model of aging that predicts patterns of survival and fertility curves for Mediterranean fruit flies. Mathematical and simulation models of individual physiological processes were constructed in terms of stochastic differential equations. The free radical theory of aging ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/B:BGEN.0000006559.59110.10
更新日期:2003-01-01 00:00:00
abstract::We used the Fischer 344 rat as a model for aging effects on the heart. Cardiac interfibrillar mitochondria (IFM), located between the myofibrils, exhibit a decrease in protein yield and oxidative phosphorylation through complex III and IV in elderly (24 months) compared to adult controls (6 months). In contrast, subsa...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1015251212039
更新日期:2002-01-01 00:00:00
abstract::Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bat...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9592-x
更新日期:2015-12-01 00:00:00
abstract::The primary determinant of survival during aging is the energetic efficiency and metabolic stability required to counter the accumulated internal and external stresses of a lifetime. Hence, genetically stress-resistant individuals should accumulate with age; frailer, less robust, less energetically efficient and less ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-006-9064-4
更新日期:2007-04-01 00:00:00
abstract::eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not m...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1010029723081
更新日期:2000-01-01 00:00:00
abstract::The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09867-x
更新日期:2020-06-01 00:00:00
abstract::Death-associated protein 6 (DAXX) is a ubiquitous protein implicated in various cellular processes such as apoptosis, tumorigenesis, development and transcription. The role of DAXX is however ambiguous and many contradictory results regarding its function in apoptosis upon various cellular stresses are described in th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9651-y
更新日期:2016-11-01 00:00:00
abstract::When mortality (μ), aging rate (γ) and age (t) are treated according to the Gompertz model μ(t) = μ0eγt (GM), any mean age corresponds to a manifold of paired reciprocally changing μ0 and γ. Therefore, any noisiness of data used to derive GM parameters makes them negatively correlated. Besides this artifactual factor ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09828-z
更新日期:2019-12-01 00:00:00
abstract::The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09861-3
更新日期:2020-06-01 00:00:00
abstract::The current linear no-threshold paradigm assumes that any exposure to ionizing radiation carries some risk, thus every effort should be made to maintain the exposures as low as possible. We examined whether background radiation impacts human longevity and cancer mortality. Our data covered the entire US population of ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09909-4
更新日期:2021-01-22 00:00:00
abstract::Sarcopenia, defined as the age-related loss of muscle mass, subsequently has a negative effect on strength, metabolic rate and functionality leading to a reduced quality of life. With the projected increase in life expectancy, the incidence of muscle loss may rise and further drain the health care system, with greater...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-011-9327-6
更新日期:2011-08-01 00:00:00
abstract::The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9274-7
更新日期:2010-12-01 00:00:00
abstract::In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to s...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-018-9748-6
更新日期:2018-07-01 00:00:00
abstract::Regular exercise is an important part of a healthy lifestyle, as it helps maintain a healthy weight and reduces the risk of chronic diseases. We explored the effects of lifelong exercise and aging on rat metabolism through a metabolomics approach. Thirty-six rats were divided into four equal groups: exercise during th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09871-1
更新日期:2020-10-01 00:00:00
abstract::Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9598-4
更新日期:2015-12-01 00:00:00
abstract::There is a viewpoint that suppression of the proliferative capacity of cells and impairment of the regeneration of tissues and organs in aging are a consequence of specially arisen during evolution mechanisms that reduce the risk of malignant transformation and, thus, protect against cancer. We believe that the restri...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9468-x
更新日期:2013-12-01 00:00:00
abstract::Oxidative damage has been proposed as an important factor in the progression of pathological and non-pathological age-related functional declines. Here, we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidant Manganese Superoxide Dismutase (Sod2). We find that the decline of s...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9210-2
更新日期:2009-10-01 00:00:00
abstract::We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09848-9
更新日期:2020-04-01 00:00:00
abstract::Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-09793-z
更新日期:2019-04-01 00:00:00
abstract::Oxidative stress caused by reactive oxygen species is proposed to cause age related muscle wasting (sarcopenia). Reversible oxidation of protein thiols by reactive oxygen species can affect protein function, so we evaluated whether muscle wasting in normal aging was associated with a pervasive increase in reversible o...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9483-y
更新日期:2014-02-01 00:00:00
abstract::Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9410-7
更新日期:2013-02-01 00:00:00