Protein degradation during aging: the lysosome-, the calpain- and the proteasome-dependent cellular proteolytic systems.

Abstract:

:Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the increased failure of homeostasis during aging is due to the impaired function of the major cellular proteolytic mechanisms mediated by the lysosome, the calpains and the proteasome. This article will address the issue of the function of these cellular proteolytic systems during aging.

journal_name

Biogerontology

journal_title

Biogerontology

authors

Chondrogianni N,Fragoulis EG,Gonos ES

doi

10.1023/a:1015236203379

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

121-3

issue

1-2

eissn

1389-5729

issn

1573-6768

journal_volume

3

pub_type

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