Abstract:
:Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the increased failure of homeostasis during aging is due to the impaired function of the major cellular proteolytic mechanisms mediated by the lysosome, the calpains and the proteasome. This article will address the issue of the function of these cellular proteolytic systems during aging.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Chondrogianni N,Fragoulis EG,Gonos ESdoi
10.1023/a:1015236203379keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
121-3issue
1-2eissn
1389-5729issn
1573-6768journal_volume
3pub_type
杂志文章相关文献
BIOGERONTOLOGY文献大全abstract::Longevity is mainly conditioned by genetic, epigenetic and environmental factors. Different genetic modifications seem to be positively associated to longevity, including SNPs in SIRT1, APOE, FOXO3A, ACE, ATM, NOS1 and NOS2 gene. Epigenetic changes as DNA hyper- and hypo-methylation influence significantly human longe...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-019-09824-3
更新日期:2019-10-01 00:00:00
abstract::The aging theory postulates that this process may be due to the accumulation of oxidative damage in cells and molecules. The present study has investigated the effect of castration in old female rats on various parameters related to the antioxidant properties of several cellular fractions obtained from the liver, and ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9089-3
更新日期:2007-10-01 00:00:00
abstract::We studied vascular function in quiescent aortas from senescence-accelerated resistant (SAM-R1) and prone (SAM-P8) mice. Myographical studies of thoracic aorta segments from 6-7 month-old mice showed that the contractility of SAM-P8 aortas was markedly higher than that of SAM-R1 after KCl depolarization or phenylephri...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9108-4
更新日期:2007-12-01 00:00:00
abstract::The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9276-5
更新日期:2010-10-01 00:00:00
abstract::The predominant molecular symptom of ageing is the accumulation of altered gene products. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin activity. P...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9110-x
更新日期:2008-02-01 00:00:00
abstract::In order to know if insulin-like signalling is involved in the control of oxidative stress in mammalian tissues in relation to aging, ad libitum-fed and caloric restricted Wistar rats were treated during 2 weeks with GH and insulin. The most consistent effect of the hormonal treatments was an increase in plasma IGF-1 ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-004-7380-0
更新日期:2005-01-01 00:00:00
abstract::In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to s...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-018-9748-6
更新日期:2018-07-01 00:00:00
abstract::In the present study, we investigated whether the length of light/dark cycle could influence the pre-adult developmental time and adult life span in Drosophila melanogaster. Flies were reared to adulthood and maintained as adults under both 24-h (light/dark 12:12 h) and 48-h (light/dark 24:24 h) cycles. The flies rear...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9146-6
更新日期:2008-10-01 00:00:00
abstract::During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1023/a:1010004901256
更新日期:2001-01-01 00:00:00
abstract::Associations have been reported between plasma Cu and Zn levels and the incidence of the most important age-related diseases. Previously proposed methods of using plasma Cu/Zn as a predictor of all-cause mortality have been derived from populations in which old and very old subjects were underrepresented. The purpose ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9251-1
更新日期:2010-06-01 00:00:00
abstract::Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a de novo genetic mutation that leads to the accumulation of a splicing isoform of lamin A termed progerin. Progerin expression alters the organization of the nuclear lamina and chromatin. The life expectancy of HGPS patients is severe...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-015-9602-z
更新日期:2016-02-01 00:00:00
abstract::An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-019-09801-w
更新日期:2019-06-01 00:00:00
abstract::Biogerontology is the study of the aging of biological systems. This review addresses the relationship between chemistry and biology during aging, proposing that chemistry is responsible for the aging of biological systems. In the continuing struggle between chemistry and biology, chemistry is always the short-term, t...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1023/a:1010034213093
更新日期:2000-01-01 00:00:00
abstract::Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9082-x
更新日期:2007-08-01 00:00:00
abstract::Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9399-y
更新日期:2012-10-01 00:00:00
abstract::Gene expression in aging kidney and pituitary was determined by subtractive hybridization, DNA microarrays and RT-PCR. Kidneys and pituitary were removed from 10- and 30-month-old female WAG/Rij rats, which were free from chronic progressive nephrosis and had a low incidence of pituitary tumors with age. From 350 cDNA...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/b:bgen.0000017685.91381.40
更新日期:2004-01-01 00:00:00
abstract::Calorie restriction (CR) extends lifespan in a remarkable range of organisms. However, the mechanisms of CR related to the longevity effects are not fully elucidated to date. Using human fibroblast Hs68 (Hs68) cells cultured at a lower level of medium glucose (i.e., glucose restriction; GR) to mimic CR, we investigate...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-014-9528-x
更新日期:2015-02-01 00:00:00
abstract::Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9787-z
更新日期:2019-04-01 00:00:00
abstract::In this study, we have assessed the impact of vitamin E and exercise on acquisition and retention of spatial memory for a given task in aging rats, using a T-maze. Acetylcholine esterase (AChE) and cholineacetyl transferase (ChAT) activities and acetylcholine (ACh) were measured in the cerebral cortex (CC) of male Wis...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9154-6
更新日期:2009-02-01 00:00:00
abstract::During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9230-6
更新日期:2010-02-01 00:00:00
abstract::Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09796-4
更新日期:2019-06-01 00:00:00
abstract::Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9661-9
更新日期:2017-02-01 00:00:00
abstract::Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09891-x
更新日期:2020-12-01 00:00:00
abstract::Changes in the levels of O-linked N-acetyl-glucosamine (O-GlcNAc) on nucleocytoplasmic protein have been associated with a number of age-related diseases such as Alzheimer's and diabetes; however, there is relatively little information regarding the impact of age on tissue O-GlcNAc levels. Therefore, the goal of this ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9123-5
更新日期:2008-06-01 00:00:00
abstract::With advancing age, memory declines through different mechanisms including dysregulation of expression of synaptic plasticity genes in hippocampus. Increasing evidences suggest that these synaptic plasticity genes are regulated through epigenetic modifications. Recently we have reported that the neuronal immediate ear...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09850-1
更新日期:2020-04-01 00:00:00
abstract::Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9164-4
更新日期:2009-04-01 00:00:00
abstract::Accumulating studies have argued that the mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that promotes longevity in model organisms. In the present study, we screened an off-patent drug library to identify compounds that activate UPRmt using a mitochondrial chaperone hsp-6::GFP repo...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09907-6
更新日期:2021-02-01 00:00:00
abstract::After reaching adulthood, orderly repair is probably one of the most important mechanisms throughout lifetime. Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development. Organ failure in the ageing organism...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9453-4
更新日期:2013-12-01 00:00:00
abstract::Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9410-7
更新日期:2013-02-01 00:00:00
abstract::Previously, extremely low, nanomolar concentrations of the mitochondria-targeted plastoquinone derivative SkQ1 (10-(6'-plastoquinonyl) decyltriphenylphosphonium) were shown to prolong the lifespan of male and female Drosophila melanogaster by about 10 % (Anisimov et al., Biochemistry (Moscow) 73:1329-1342, 2008). Usin...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9404-5
更新日期:2012-12-01 00:00:00