Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population.

abstract：:Aging is associated with accumulation of toxic intracellular and extracellular protein aggregates. Cells manage "aged" proteins by mobilizing their molecular chaperones or heat shock proteins that are also considered as determinants of lifespan in diverse species. In this study, we tested whether an exogenous addition...

journal_title：Biogerontology

authors： Deocaris CC,Takano S,Priyandoko D,Kaul Z,Yaguchi T,Kraft DC,Yamasaki K,Kaul SC,Wadhwa R

更新日期：2008-08-01 00:00:00

abstract：:Menopause marks the end of the reproductive life span of women and is characterized by a dramatic drop of circulating estrogen. Hormone replacement therapy (HRT) has been successfully used to treat the symptoms of menopause because estrogen has strong suppressive effects on climacteric complaints. As the hypothalamo-p...

journal_title：Biogerontology

authors： Böttner M,Wuttke W

更新日期：2005-01-01 00:00:00

abstract：:Numerous reports implicate increased oxidative stress in the functional and structural changes occurring in the brain and other organs as a part of the normal aging process. Dietary restriction (DR) has long been shown to be life-prolonging intervention in several species. This study was aimed to assess the potential ...

journal_title：Biogerontology

authors： Sharma S,Singh R,Kaur M,Kaur G

更新日期：2010-04-01 00:00:00

abstract：:Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related diseases in many organisms including humans. The present study aimed to examine the influence of long-term DR on the BDNF system at the transcriptional and translational levels in the cortex and hippocampus of middle-aged ...

journal_title：Biogerontology

authors： Smiljanic K,Pesic V,Mladenovic Djordjevic A,Pavkovic Z,Brkic M,Ruzdijic S,Kanazir S

更新日期：2015-02-01 00:00:00

abstract：:In mammals suprachiasmatic nucleus (SCN), acts as a light entrainable master clock and by generation of temporal oscillations regulates the peripheral organs acting as autonomous clocks resulting in overt behavioral and physiological rhythms. SCN also controls synthesis and release of melatonin (hormonal message for d...

journal_title：Biogerontology

authors： Vinod C,Jagota A

更新日期：2016-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) are formed by all aerobic organisms, and are involved in the numerous physiological and pathophysiological processes. Opioid peptides belong to a class of bioactive compounds of great interest because of their opiate-like activity. We determined the influence of methionine-enkephalin (MEN...

journal_title：Biogerontology

authors： Sobocanec S,Kusić B,Sverko V,Balog T,Marotti T

更新日期：2006-02-01 00:00:00

abstract：:Two sibling Drosophila species dramatically divergent in longevity, Drosophila buzzatii and D. koepferae, were examined for possible effects of both developmental culture medium and dietary composition (DC) on longevity. Longevity was greatly increased in the longer lived D. buzzatii when flies were reared and fed on ...

journal_title：Biogerontology

authors： Gomez FH,Sambucetti P,Norry FM

更新日期：2013-08-01 00:00:00

abstract：:Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven by highly conserved cell intrinsic processes, and a set of unifying hallmarks of ageing has been defined. Here, we survey reports of age-l...

journal_title：Biogerontology

authors： Frenk S,Houseley J

更新日期：2018-12-01 00:00:00

abstract：:In the present study, we investigated whether the length of light/dark cycle could influence the pre-adult developmental time and adult life span in Drosophila melanogaster. Flies were reared to adulthood and maintained as adults under both 24-h (light/dark 12:12 h) and 48-h (light/dark 24:24 h) cycles. The flies rear...

journal_title：Biogerontology

authors： Vaiserman AM,Pisaruck AV,Timchenko AN,Voitenko VP,Koshel NM,Grigoriev PE

更新日期：2008-10-01 00:00:00

abstract：:Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...

journal_title：Biogerontology

authors： Augustyniak J,Lenart J,Zychowicz M,Stepien PP,Buzanska L

更新日期：2017-08-01 00:00:00

abstract：:Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...

journal_title：Biogerontology

authors： Sipilä S,Narici M,Kjaer M,Pöllänen E,Atkinson RA,Hansen M,Kovanen V

更新日期：2013-06-01 00:00:00

abstract：:Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...

journal_title：Biogerontology

authors： Wensink M

更新日期：2013-02-01 00:00:00

abstract：:The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...

journal_title：Biogerontology

authors： Mocchegiani E,Basso A,Giacconi R,Piacenza F,Costarelli L,Pierpaoli S,Malavolta M

更新日期：2010-10-01 00:00:00

abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a de novo genetic mutation that leads to the accumulation of a splicing isoform of lamin A termed progerin. Progerin expression alters the organization of the nuclear lamina and chromatin. The life expectancy of HGPS patients is severe...

journal_title：Biogerontology

authors： Brassard JA,Fekete N,Garnier A,Hoesli CA

更新日期：2016-02-01 00:00:00

abstract：:There is increasing support for the notion that genetic variation for lifespan, both within and between species, is correlated with variation in the efficiency of the free radical scavenging system and the ability to withstand oxidative stress. In Drosophila, resistance to dietary paraquat, a free radical generator, i...

journal_title：Biogerontology

authors： Vermeulen CJ,Van De Zande L,Bijlsma R

更新日期：2005-12-01 00:00:00

abstract：:High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complex...

journal_title：Biogerontology

authors： Ezcurra M

更新日期：2018-12-01 00:00:00

abstract：:Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (a...

journal_title：Biogerontology

authors： Napolioni V,Lucarini N

更新日期：2010-08-01 00:00:00

abstract：:Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer's, dialysis related amyloidosis (DRA), atherosclerosis and Parkinson's as well as physiological aging. This review attempts to summarize the data on glycation in relation...

journal_title：Biogerontology

authors： Suji G,Sivakami S

更新日期：2004-01-01 00:00:00

abstract：:Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in a...

journal_title：Biogerontology

authors： Yanai H,Budovsky A,Tacutu R,Fraifeld VE

更新日期：2011-12-01 00:00:00

abstract：:There is a viewpoint that suppression of the proliferative capacity of cells and impairment of the regeneration of tissues and organs in aging are a consequence of specially arisen during evolution mechanisms that reduce the risk of malignant transformation and, thus, protect against cancer. We believe that the restri...

journal_title：Biogerontology

authors： Khokhlov AN

更新日期：2013-12-01 00:00:00

abstract：:Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young...

journal_title：Biogerontology

authors： Srivastava D,Arya U,SoundaraRajan T,Dwivedi H,Kumar S,Subramaniam JR

更新日期：2008-10-01 00:00:00

abstract：:eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not m...

journal_title：Biogerontology

authors： Silar P,Rossignol M,Haedens V,Derhy Z,Mazabraud A

更新日期：2000-01-01 00:00:00

abstract：:Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and conditional effects of ge...

journal_title：Biogerontology

authors： Ukraintseva S,Yashin A,Arbeev K,Kulminski A,Akushevich I,Wu D,Joshi G,Land KC,Stallard E

更新日期：2016-02-01 00:00:00

abstract：:Sarcopenia, characterized by profound muscle atrophy and the loss of contractile function, contributes significantly to the development of frailty and functional impairment in older age. Although present in aging humans, rat models have failed to clearly demonstrate a similar degree of this age-associated loss of musc...

journal_title：Biogerontology

authors： Rice KM,Linderman JK,Kinnard RS,Blough ER

更新日期：2005-01-01 00:00:00

abstract：:Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the...

journal_title：Biogerontology

authors： Costarelli L,Giacconi R,Malavolta M,Basso A,Piacenza F,Provinciali M,Maggio MG,Corsonello A,Lattanzio F

更新日期：2017-04-01 00:00:00

abstract：:In order to know if insulin-like signalling is involved in the control of oxidative stress in mammalian tissues in relation to aging, ad libitum-fed and caloric restricted Wistar rats were treated during 2 weeks with GH and insulin. The most consistent effect of the hormonal treatments was an increase in plasma IGF-1 ...

journal_title：Biogerontology

authors： Sanz A,Gredilla R,Pamplona R,Portero-Otín M,Vara E,Tresguerres JA,Barja G

更新日期：2005-01-01 00:00:00

abstract：:Adipose tissue plays a pivotal role in ageing and longevity; many studies, both human and animal, have focussed on the effects of food limitation. Here we present a new model based on striking differences between two 'normal' inbred strains of albino Wistar rats the Charles River (CR) and Harlan Olac (HO) that have ma...

journal_title：Biogerontology

authors： Kunjara S,Greenbaum AL,Rademacher TW,McLean P

更新日期：2010-08-01 00:00:00

abstract：:Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...

journal_title：Biogerontology

authors： Jagota A,Mattam U

更新日期：2017-08-01 00:00:00

abstract：:Behavioral symptoms of sickness, such as fever and motor activity are a coordinated set of changes that develop during infection. The aim of study was to compare the sickness behaviour (SB) in healthy old and young rats treated with pyrogenic dose of endotoxin and to check their glutathione level. Before experimentati...

journal_title：Biogerontology

authors： Wrotek S,Jędrzejewski T,Nowakowska A,Kozak W

更新日期：2016-08-01 00:00:00

abstract：:The current linear no-threshold paradigm assumes that any exposure to ionizing radiation carries some risk, thus every effort should be made to maintain the exposures as low as possible. We examined whether background radiation impacts human longevity and cancer mortality. Our data covered the entire US population of ...

journal_title：Biogerontology

authors： David E,Wolfson M,Fraifeld VE

更新日期：2021-01-22 00:00:00