Abstract:
:Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in adipose tissue SASP and dysfunction. Young and aging rat were given L-carnitine by gavage. Next, we detected the senescence, cytokines expression, chronic inflammation and insulin resistance of adipose tissue. Additionally, JNK/p53 pathway was estimated. Our results show a significant increase expression of SASP components in the adipose tissue of aging rats compared to young rats. Further, we found that infiltration of immune cells and the expression of pro-inflammatory cytokines were enhanced in aging adipose tissue while insulin signaling activity was reduced in aging adipose tissue. Interestingly, L-carnitine markedly reduced the expression of SASP factors. L-Carnitine could significantly reduce chronic inflammation, improving insulin resistance. Further, L-carnitine inhibited SASP by inhibiting JNK/p53 pathway. L-Carnitine inhibited SASP by JNK/p53 pathway and attenuated adipose tissue dysfunction of aging.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Yang LW,Song M,Li YL,Liu YP,Liu C,Han L,Wang ZH,Zhang W,Xing YQ,Zhong Mdoi
10.1007/s10522-018-9787-zsubject
Has Abstractpub_date
2019-04-01 00:00:00pages
203-211issue
2eissn
1389-5729issn
1573-6768pii
10.1007/s10522-018-9787-zjournal_volume
20pub_type
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