Abstract:
:Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young adults extends the C. elegans lifespan robustly at 25 degrees C. Most importantly, the reserpine treated long lived worms are active (locomotion and pharyngeal pumping) for a long time thereby conferring high quality throughout life. Reserpine mediated lifespan extension is independent of the daf-16 pathway and partly requires serotonin. Reserpine treatment makes the worms highly thermotolerant. Thus, in addition to its known function, reserpine is able to provide stress tolerance and lifespan extension in C. elegans.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Srivastava D,Arya U,SoundaraRajan T,Dwivedi H,Kumar S,Subramaniam JRdoi
10.1007/s10522-008-9139-5subject
Has Abstractpub_date
2008-10-01 00:00:00pages
309-16issue
5eissn
1389-5729issn
1573-6768journal_volume
9pub_type
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