Glucose, glycation and aging.

abstract：:With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotei...

journal_title：Biogerontology

authors： Gee JR,Ding Q,Keller JN

更新日期：2006-04-01 00:00:00

abstract：:Inflammation is an underlying basis for the molecular alterations that link aging and age-related pathological processes. In a previous study, we found that secretory phospholipase A(2) (sPLA(2)) induced cellular senescence in human dermal fibroblasts (HDFs). To further investigate the association of inflammation with...

journal_title：Biogerontology

authors： Yang HH,Kim C,Jung B,Kim KS,Kim JR

更新日期：2011-06-01 00:00:00

abstract：:It is known that a global decrease in food ingestion (dietary restriction, DR) lowers mitochondrial ROS generation (mitROS) and oxidative stress in young immature rats. This seems to be caused by the decreased methionine ingestion of DR animals. This is interesting since isocaloric methionine restriction in the diet (...

journal_title：Biogerontology

authors： Sanchez-Roman I,Gómez A,Pérez I,Sanchez C,Suarez H,Naudí A,Jové M,Lopez-Torres M,Pamplona R,Barja G

更新日期：2012-08-01 00:00:00

abstract：:Chronic oxidative stress plays a central role in the pathogenesis of many diseases, including HIV-1 associated disorders. Concomitantly with the decline of endogenous antioxidant systems, it was reported that HIV-1-related proteins increase the production of radical species in cells and tissues that are not directly i...

journal_title：Biogerontology

authors： Davinelli S,Scapagnini G,Denaro F,Calabrese V,Benedetti F,Krishnan S,Curreli S,Bryant J,Zella D

更新日期：2014-01-01 00:00:00

abstract：:The long-term effects of X-irradiation with 0.25, 0.5, 0.75 and 1 Gy of 1 h eggs on the fitness-related life history traits in adult Drosophila melanogaster fruit flies and their offspring were investigated. Following irradiation with 0.25, 0.5 and 0.75 Gy, both F0 and F1 flies have decreased adult body weight and inc...

journal_title：Biogerontology

authors： Vaiserman AM,Koshel NM,Mechova LV,Voitenko VP

更新日期：2004-01-01 00:00:00

abstract：:The aging theory postulates that this process may be due to the accumulation of oxidative damage in cells and molecules. The present study has investigated the effect of castration in old female rats on various parameters related to the antioxidant properties of several cellular fractions obtained from the liver, and ...

journal_title：Biogerontology

authors： Kireev RA,Tresguerres AF,Vara E,Ariznavarreta C,Tresguerres JA

更新日期：2007-10-01 00:00:00

abstract：:In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to s...

journal_title：Biogerontology

authors： Zole E,Ranka R

更新日期：2018-07-01 00:00:00

abstract：:Obesity is associated with functional limitations in muscle performance and increased likelihood of developing a functional disability such as mobility, strength, postural and dynamic balance limitations. The consensus is that obese individuals, regardless of age, have a greater absolute maximum muscle strength compar...

journal_title：Biogerontology

authors： Tomlinson DJ,Erskine RM,Morse CI,Winwood K,Onambélé-Pearson G

更新日期：2016-06-01 00:00:00

abstract：:Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...

journal_title：Biogerontology

authors： Augustyniak J,Lenart J,Zychowicz M,Stepien PP,Buzanska L

更新日期：2017-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) are formed by all aerobic organisms, and are involved in the numerous physiological and pathophysiological processes. Opioid peptides belong to a class of bioactive compounds of great interest because of their opiate-like activity. We determined the influence of methionine-enkephalin (MEN...

journal_title：Biogerontology

authors： Sobocanec S,Kusić B,Sverko V,Balog T,Marotti T

更新日期：2006-02-01 00:00:00

abstract：:Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and...

journal_title：Biogerontology

authors： Bohr VA,Brosh RM Jr,von Kobbe C,Opresko P,Karmakar P

更新日期：2002-01-01 00:00:00

abstract：:The effects of oxidative stress (OS) on the rat erythrocytes (RBCs) that were fractionated on the percoll/BSA gradient into young and old cells were studied to find out if the altered Na+/H+ and Cl⁻/ HCO3⁻ antiporters and in turn the intracellular pH (pHi) could act as one of the promoters of cell death. Old cells wer...

journal_title：Biogerontology

authors： Asha Devi S,Shiva Shankar Reddy CS,Subramanyam MV

更新日期：2009-12-01 00:00:00

abstract：:Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young...

journal_title：Biogerontology

authors： Srivastava D,Arya U,SoundaraRajan T,Dwivedi H,Kumar S,Subramaniam JR

更新日期：2008-10-01 00:00:00

abstract：:During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...

journal_title：Biogerontology

authors： Holliday R

更新日期：2001-01-01 00:00:00

abstract：:Cancers are different diseases that start and evolve each in its own manner, and trigger variable responses from the organism depending upon the neoplastic process under way and upon the physiopathology of the organism. The clinical incidence of the different cancers is spread through the human life span, with regiona...

journal_title：Biogerontology

authors： Macieira-Coelho A

更新日期：2001-01-01 00:00:00

abstract：:Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...

journal_title：Biogerontology

authors： Vaiserman A,Cuttler JM,Socol Y

更新日期：2021-01-09 00:00:00

abstract：:Parametric models for survival data help to differentiate aging from other lifespan determinants. However, such inferences suffer from small sizes of experimental animal samples and variable animals handling by different labs. We analyzed control data from a single laboratory where interventions in murine lifespan wer...

journal_title：Biogerontology

authors： Golubev A,Panchenko A,Anisimov V

更新日期：2018-10-01 00:00:00

abstract：:Longevity is mainly conditioned by genetic, epigenetic and environmental factors. Different genetic modifications seem to be positively associated to longevity, including SNPs in SIRT1, APOE, FOXO3A, ACE, ATM, NOS1 and NOS2 gene. Epigenetic changes as DNA hyper- and hypo-methylation influence significantly human longe...

journal_title：Biogerontology

authors： Costa D,Scognamiglio M,Fiorito C,Benincasa G,Napoli C

更新日期：2019-10-01 00:00:00

abstract：:Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...

journal_title：Biogerontology

authors： Witham MD

更新日期：2019-04-01 00:00:00

abstract：:In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescen...

journal_title：Biogerontology

authors： Maciel-Barón LÁ,Morales-Rosales SL,Silva-Palacios A,Rodríguez-Barrera RH,García-Álvarez JA,Luna-López A,Pérez VI,Torres C,Königsberg M

更新日期：2018-10-01 00:00:00

abstract：:An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...

journal_title：Biogerontology

authors： Xia J,Gravato-Nobre M,Ligoxygakis P

更新日期：2019-06-01 00:00:00

abstract：:Oxidative damage has been proposed as an important factor in the progression of pathological and non-pathological age-related functional declines. Here, we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidant Manganese Superoxide Dismutase (Sod2). We find that the decline of s...

journal_title：Biogerontology

authors： Piazza N,Hayes M,Martin I,Duttaroy A,Grotewiel M,Wessells R

更新日期：2009-10-01 00:00:00

abstract：:CD4+ T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4+ T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearanc...

journal_title：Biogerontology

authors： Lorenzo EC,Bartley JM,Haynes L

更新日期：2018-12-01 00:00:00

abstract：:Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...

journal_title：Biogerontology

authors： Russ DW,Krause J,Wills A,Arreguin R

更新日期：2012-10-01 00:00:00

abstract：:When mortality (μ), aging rate (γ) and age (t) are treated according to the Gompertz model μ(t) = μ0eγt (GM), any mean age corresponds to a manifold of paired reciprocally changing μ0 and γ. Therefore, any noisiness of data used to derive GM parameters makes them negatively correlated. Besides this artifactual factor ...

journal_title：Biogerontology

authors： Golubev A

更新日期：2019-12-01 00:00:00

abstract：:Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...

journal_title：Biogerontology

authors： Rolt A,Nair A,Cox LS

更新日期：2019-06-01 00:00:00

abstract：:Regular exercise is an important part of a healthy lifestyle, as it helps maintain a healthy weight and reduces the risk of chronic diseases. We explored the effects of lifelong exercise and aging on rat metabolism through a metabolomics approach. Thirty-six rats were divided into four equal groups: exercise during th...

journal_title：Biogerontology

authors： Tzimou A,Benaki D,Nikolaidis S,Mikros E,Taitzoglou I,Mougios V

更新日期：2020-10-01 00:00:00

abstract：:The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated b...

journal_title：Biogerontology

authors： Rohrbach S,Simm A,Pregla R,Franke C,Katschinski DM

更新日期：2005-01-01 00:00:00

abstract：:Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...

journal_title：Biogerontology

authors： Sipilä S,Narici M,Kjaer M,Pöllänen E,Atkinson RA,Hansen M,Kovanen V

更新日期：2013-06-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells represent a well-established T cell lineage characterised in humans by TCR consisting of an invariant alpha chain encoded by Valpha24-JalphaQ genes, paired preferentially with a Vbeta11 chain. iNKT cells also share some characteristics with NK cells, such as the expression of th...

journal_title：Biogerontology

authors： Peralbo E,DelaRosa O,Gayoso I,Pita ML,Tarazona R,Solana R

更新日期：2006-10-01 00:00:00