Abstract：
:Parametric models for survival data help to differentiate aging from other lifespan determinants. However, such inferences suffer from small sizes of experimental animal samples and variable animals handling by different labs. We analyzed control data from a single laboratory where interventions in murine lifespan were studied over decades. The minimal Gompertz model (GM) was found to perform best with most murine strains. However, when several control datasets related to a particular strain are fitted to GM, strikingly rigid interdependencies between GM parameters emerge, consistent with the Strehler-Mildvan correlation (SMC). SMC emerges even when survival patterns do not conform to GM, as with cancer-prone HER2/neu mice, which die at a log-normally distributed age. Numerical experiments show that SMC includes an artifact whose magnitude depends on dataset deviation from conformance to GM irrespectively of the noisiness of small datasets, another contributor to SMC. Still another contributor to SMC is the compensation effect of mortality (CEM): a real tradeoff between the physiological factors responsible for initial vitality and the rate of its decline. To avoid misinterpretations, we advise checking experimental results against a SMC based on historical controls or on subgroups obtained by randomization of control animals. An apparent acceleration of aging associated with a decrease in the initial mortality is invalid if it is not greater than SMC suggests. This approach applied to published data suggests that the effects of calorie restriction and of drugs believed to mimic it are different. SMC and CEM relevance to human survival patterns is discussed.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Golubev A,Panchenko A,Anisimov Vdoi
10.1007/s10522-018-9759-3subject
Has Abstractpub_date
2018-10-01 00:00:00pages
341-365issue
5eissn
1389-5729issn
1573-6768pii
10.1007/s10522-018-9759-3journal_volume
19pub_type
杂志文章相关文献
BIOGERONTOLOGY文献大全abstract：:Drosophila melanogaster flies were exposed to hypergravity starting at two days of age, the range of gravity levels used being 2.58-7.38 g. No longevity change was observed for exposures of less than 14 days. The longevity of males increased if they were submitted to hypergravity for durations ranging from 14 to 24 da...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1023/a:1010043914016
更新日期：2000-01-01 00:00:00
abstract：:The long-term effects of X-irradiation with 0.25, 0.5, 0.75 and 1 Gy of 1 h eggs on the fitness-related life history traits in adult Drosophila melanogaster fruit flies and their offspring were investigated. Following irradiation with 0.25, 0.5 and 0.75 Gy, both F0 and F1 flies have decreased adult body weight and inc...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-004-2571-2
更新日期：2004-01-01 00:00:00
abstract：:Histone post-translational modifications (PTMs) are involved in diverse biological processes and methylation was regarded as a long-term epigenetic mark. Though aging represented one of the major risk factors for neurodegenerative diseases, no systematic investigations had correlated the patterns of histone PTMs in th...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-009-9231-5
更新日期：2010-02-01 00:00:00
abstract：:Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-017-9711-y
更新日期：2017-08-01 00:00:00
abstract：:Aging is associated with accumulation of toxic intracellular and extracellular protein aggregates. Cells manage "aged" proteins by mobilizing their molecular chaperones or heat shock proteins that are also considered as determinants of lifespan in diverse species. In this study, we tested whether an exogenous addition...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9136-8
更新日期：2008-08-01 00:00:00
abstract：:Researchers working in the area of ageing have found numerous manifestations of this process at the molecular biological level, including DNA and protein damage, accumulation of metabolic by-products, lipids peroxidation, macromolecular cross-linking, non-enzymatic glycosylation, anti-oxidant/pro-oxidant misbalance, r...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-017-9728-2
更新日期：2018-02-01 00:00:00
abstract：:Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and conditional effects of ge...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-015-9600-1
更新日期：2016-02-01 00:00:00
abstract：:The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9274-7
更新日期：2010-12-01 00:00:00
abstract：:We propose a "protein and energy" free radical model of aging that predicts patterns of survival and fertility curves for Mediterranean fruit flies. Mathematical and simulation models of individual physiological processes were constructed in terms of stochastic differential equations. The free radical theory of aging ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1023/B:BGEN.0000006559.59110.10
更新日期：2003-01-01 00:00:00
abstract：:Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-020-09891-x
更新日期：2020-12-01 00:00:00
abstract：:Biogerontology is the study of the aging of biological systems. This review addresses the relationship between chemistry and biology during aging, proposing that chemistry is responsible for the aging of biological systems. In the continuing struggle between chemistry and biology, chemistry is always the short-term, t...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1023/a:1010034213093
更新日期：2000-01-01 00:00:00
abstract：:The aging theory postulates that this process may be due to the accumulation of oxidative damage in cells and molecules. The present study has investigated the effect of castration in old female rats on various parameters related to the antioxidant properties of several cellular fractions obtained from the liver, and ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-007-9089-3
更新日期：2007-10-01 00:00:00
abstract：:Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9164-4
更新日期：2009-04-01 00:00:00
abstract：:The predominant molecular symptom of ageing is the accumulation of altered gene products. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin activity. P...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-007-9110-x
更新日期：2008-02-01 00:00:00
abstract：:During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1023/a:1010004901256
更新日期：2001-01-01 00:00:00
abstract：:Behavioral symptoms of sickness, such as fever and motor activity are a coordinated set of changes that develop during infection. The aim of study was to compare the sickness behaviour (SB) in healthy old and young rats treated with pyrogenic dose of endotoxin and to check their glutathione level. Before experimentati...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-016-9636-x
更新日期：2016-08-01 00:00:00
abstract：:Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-012-9399-y
更新日期：2012-10-01 00:00:00
abstract：:In the present study, we investigated whether the length of light/dark cycle could influence the pre-adult developmental time and adult life span in Drosophila melanogaster. Flies were reared to adulthood and maintained as adults under both 24-h (light/dark 12:12 h) and 48-h (light/dark 24:24 h) cycles. The flies rear...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9146-6
更新日期：2008-10-01 00:00:00
abstract：:Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9316-1
更新日期：2011-04-01 00:00:00
abstract：:Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1023/a:1015223917491
更新日期：2002-01-01 00:00:00
abstract：:Melatonin synthesis is disordered in patients with Alzheimer's disease (AD). To determine the role of melatonin in the pathogenesis of AD, suitable animal models are needed. The OXYS rats are an experimental model of accelerated senescence that has also been proposed as a spontaneous rat model of AD-like pathology. In...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-014-9547-7
更新日期：2015-06-01 00:00:00
abstract：:There are currently no reliable biomarkers of ageing. A biomarker should indicate biological age, that is, the amount of an animal's total lifespan it has lived and, therefore, the amount of time it has remaining. Some potential biomarkers cannot be validated as their measurement involves harm or death of the animal, ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-012-9393-4
更新日期：2012-10-01 00:00:00
abstract：:For a period of 6-15 days prior to death, the fecundity and virility of Drosophila melanogaster fall significantly below those of same-aged flies that are not near death. It is likely that other aspects of physiology may decline during this period. This study attempts to document changes in two physiological character...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-012-9398-z
更新日期：2012-10-01 00:00:00
abstract：:Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-013-9425-8
更新日期：2013-06-01 00:00:00
abstract：:Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-016-9661-9
更新日期：2017-02-01 00:00:00
abstract：:Ageing can have profound effects on the post-mitotic organ of behaviour, the brain. As yet the precise causes of these deleterious effects are unknown. However, clear insights into the putative mechanisms and consequences of ageing in the CNS have been achieved through the use of invertebrate models. It is now clear t...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1023/a:1011597420036
更新日期：2001-01-01 00:00:00
abstract：:The mutation level (chromosome aberrations covering telomere regions), modifications of chromosome structure (level of condensed chromatin identified by the methods of electron microscopy and differential scanning microcalorimetry; level of C-banding constitutive heterochromatin; transcriptional activity of DNA-depend...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1023/a:1013266411263
更新日期：2001-01-01 00:00:00
abstract：:Oxidative damage has been proposed as an important factor in the progression of pathological and non-pathological age-related functional declines. Here, we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidant Manganese Superoxide Dismutase (Sod2). We find that the decline of s...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9210-2
更新日期：2009-10-01 00:00:00
abstract：:Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. ...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-008-9131-0
更新日期：2008-08-01 00:00:00
abstract：:FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malo...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-015-9611-y
更新日期：2016-04-01 00:00:00
