Pathways defective in the human premature aging disease Werner syndrome.


:Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and role of this protein is discussed in the light of how it functions in the aging process.






Bohr VA,Brosh RM Jr,von Kobbe C,Opresko P,Karmakar P





Has Abstract


2002-01-01 00:00:00












  • Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population.

    abstract::Associations have been reported between plasma Cu and Zn levels and the incidence of the most important age-related diseases. Previously proposed methods of using plasma Cu/Zn as a predictor of all-cause mortality have been derived from populations in which old and very old subjects were underrepresented. The purpose ...


    pub_type: 杂志文章


    authors: Malavolta M,Giacconi R,Piacenza F,Santarelli L,Cipriano C,Costarelli L,Tesei S,Pierpaoli S,Basso A,Galeazzi R,Lattanzio F,Mocchegiani E

    更新日期:2010-06-01 00:00:00

  • Diet (zinc)-gene interaction related to inflammatory/immune response in ageing: possible link with frailty syndrome?

    abstract::The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...


    pub_type: 杂志文章


    authors: Mocchegiani E,Basso A,Giacconi R,Piacenza F,Costarelli L,Pierpaoli S,Malavolta M

    更新日期:2010-10-01 00:00:00

  • Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness.

    abstract::Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. ...


    pub_type: 杂志文章,评审


    authors: Ryall JG,Schertzer JD,Lynch GS

    更新日期:2008-08-01 00:00:00

  • Identification of cultivation-independent markers of human endothelial cell senescence in vitro.

    abstract::Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...


    pub_type: 杂志文章


    authors: Unterluggauer H,Hütter E,Voglauer R,Grillari J,Vöth M,Bereiter-Hahn J,Jansen-Dürr P,Jendrach M

    更新日期:2007-08-01 00:00:00

  • Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice.

    abstract::The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...


    pub_type: 杂志文章


    authors: Liu HW,Chang YC,Chan YC,Hu SH,Liu MY,Chang SJ

    更新日期:2020-06-01 00:00:00

  • Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species.

    abstract::An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the maintenance of homeostasis due to various endogenous and environmental challenges, leading to amassing of damages, functional deterioration of ...


    pub_type: 杂志文章,评审


    authors: Mathew R,Pal Bhadra M,Bhadra U

    更新日期:2017-02-01 00:00:00

  • Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8.

    abstract::Histone post-translational modifications (PTMs) are involved in diverse biological processes and methylation was regarded as a long-term epigenetic mark. Though aging represented one of the major risk factors for neurodegenerative diseases, no systematic investigations had correlated the patterns of histone PTMs in th...


    pub_type: 杂志文章


    authors: Wang CM,Tsai SN,Yew TW,Kwan YW,Ngai SM

    更新日期:2010-02-01 00:00:00

  • Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals.

    abstract::In order to know if insulin-like signalling is involved in the control of oxidative stress in mammalian tissues in relation to aging, ad libitum-fed and caloric restricted Wistar rats were treated during 2 weeks with GH and insulin. The most consistent effect of the hormonal treatments was an increase in plasma IGF-1 ...


    pub_type: 杂志文章


    authors: Sanz A,Gredilla R,Pamplona R,Portero-Otín M,Vara E,Tresguerres JA,Barja G

    更新日期:2005-01-01 00:00:00

  • Altered expression pattern of Nrf2/HO-1 axis during accelerated-senescence in HIV-1 transgenic rat.

    abstract::Chronic oxidative stress plays a central role in the pathogenesis of many diseases, including HIV-1 associated disorders. Concomitantly with the decline of endogenous antioxidant systems, it was reported that HIV-1-related proteins increase the production of radical species in cells and tissues that are not directly i...


    pub_type: 杂志文章


    authors: Davinelli S,Scapagnini G,Denaro F,Calabrese V,Benedetti F,Krishnan S,Curreli S,Bryant J,Zella D

    更新日期:2014-01-01 00:00:00

  • Genetic background, epigenetic factors and dietary interventions which influence human longevity.

    abstract::Longevity is mainly conditioned by genetic, epigenetic and environmental factors. Different genetic modifications seem to be positively associated to longevity, including SNPs in SIRT1, APOE, FOXO3A, ACE, ATM, NOS1 and NOS2 gene. Epigenetic changes as DNA hyper- and hypo-methylation influence significantly human longe...


    pub_type: 杂志文章,评审


    authors: Costa D,Scognamiglio M,Fiorito C,Benincasa G,Napoli C

    更新日期:2019-10-01 00:00:00

  • The RESOLVE concept: approaching pathophysiology of fibroproliferative disease in aged individuals.

    abstract::After reaching adulthood, orderly repair is probably one of the most important mechanisms throughout lifetime. Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development. Organ failure in the ageing organism...


    pub_type: 杂志文章,评审


    authors: Ziesche R,Golec M,Samaha E

    更新日期:2013-12-01 00:00:00

  • Expression of estrogen receptors in the hypothalamo-pituitary-ovarian axis in middle-aged rats after re-instatement of estrus cyclicity.

    abstract::During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...


    pub_type: 杂志文章


    authors: Böttner M,Leonhardt S,Wuttke W,Wedel T,Jarry H

    更新日期:2010-02-01 00:00:00

  • Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG.

    abstract::The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...


    pub_type: 杂志文章


    authors: Kumar R,Sharma A,Padwad Y,Sharma R

    更新日期:2020-06-01 00:00:00

  • Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes.

    abstract::Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...


    pub_type: 杂志文章


    authors: Hasan AU,Ohmori K,Hashimoto T,Kamitori K,Yamaguchi F,Konishi K,Noma T,Igarashi J,Yamashita T,Hirano K,Tokuda M,Minamino T,Nishiyama A,Kohno M

    更新日期:2017-02-01 00:00:00

  • Age-specificity and the evolution of senescence: a discussion.

    abstract::Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...


    pub_type: 杂志文章


    authors: Wensink M

    更新日期:2013-02-01 00:00:00

  • Resistance to oxidative stress induced by paraquat correlates well with both decreased and increased lifespan in Drosophila melanogaster.

    abstract::There is increasing support for the notion that genetic variation for lifespan, both within and between species, is correlated with variation in the efficiency of the free radical scavenging system and the ability to withstand oxidative stress. In Drosophila, resistance to dietary paraquat, a free radical generator, i...


    pub_type: 杂志文章


    authors: Vermeulen CJ,Van De Zande L,Bijlsma R

    更新日期:2005-12-01 00:00:00

  • Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism.

    abstract::Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...


    pub_type: 杂志文章


    authors: Russ DW,Boyd IM,McCoy KM,McCorkle KW

    更新日期:2015-12-01 00:00:00

  • Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.

    abstract::Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...


    pub_type: 杂志文章


    authors: Jagota A,Mattam U

    更新日期:2017-08-01 00:00:00

  • The impact of aging on CD4+ T cell responses to influenza infection.

    abstract::CD4+ T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4+ T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearanc...


    pub_type: 杂志文章,评审


    authors: Lorenzo EC,Bartley JM,Haynes L

    更新日期:2018-12-01 00:00:00

  • Effect of chronic treatments with GH, melatonin, estrogens, and phytoestrogens on oxidative stress parameters in liver from aged female rats.

    abstract::The aging theory postulates that this process may be due to the accumulation of oxidative damage in cells and molecules. The present study has investigated the effect of castration in old female rats on various parameters related to the antioxidant properties of several cellular fractions obtained from the liver, and ...


    pub_type: 杂志文章


    authors: Kireev RA,Tresguerres AF,Vara E,Ariznavarreta C,Tresguerres JA

    更新日期:2007-10-01 00:00:00

  • Involvement of IGF binding protein 5 in prostaglandin E(2)-induced cellular senescence in human fibroblasts.

    abstract::Inflammation is an underlying basis for the molecular alterations that link aging and age-related pathological processes. In a previous study, we found that secretory phospholipase A(2) (sPLA(2)) induced cellular senescence in human dermal fibroblasts (HDFs). To further investigate the association of inflammation with...


    pub_type: 杂志文章


    authors: Yang HH,Kim C,Jung B,Kim KS,Kim JR

    更新日期:2011-06-01 00:00:00

  • "SR stress" in mixed hindlimb muscles of aging male rats.

    abstract::Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...


    pub_type: 杂志文章


    authors: Russ DW,Krause J,Wills A,Arreguin R

    更新日期:2012-10-01 00:00:00

  • Deletion and dosage modulation of the eEF1A gene in Podospora anserina: effect on the life cycle.

    abstract::eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not m...


    pub_type: 杂志文章


    authors: Silar P,Rossignol M,Haedens V,Derhy Z,Mazabraud A

    更新日期:2000-01-01 00:00:00

  • Decreased frequency and proliferative response of invariant Valpha24Vbeta11 natural killer T (iNKT) cells in healthy elderly.

    abstract::Invariant natural killer T (iNKT) cells represent a well-established T cell lineage characterised in humans by TCR consisting of an invariant alpha chain encoded by Valpha24-JalphaQ genes, paired preferentially with a Vbeta11 chain. iNKT cells also share some characteristics with NK cells, such as the expression of th...


    pub_type: 杂志文章


    authors: Peralbo E,DelaRosa O,Gayoso I,Pita ML,Tarazona R,Solana R

    更新日期:2006-10-01 00:00:00

  • DAF-16 target identification in C. elegans: past, present and future.

    abstract::In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade. Identifying and...


    pub_type: 杂志文章,评审


    authors: Tullet JM

    更新日期:2015-04-01 00:00:00

  • Cross-life stage and cross-generational effects of gamma irradiations at the egg stage on Drosophila melanogaster life histories.

    abstract::The long-term effects of X-irradiation with 0.25, 0.5, 0.75 and 1 Gy of 1 h eggs on the fitness-related life history traits in adult Drosophila melanogaster fruit flies and their offspring were investigated. Following irradiation with 0.25, 0.5 and 0.75 Gy, both F0 and F1 flies have decreased adult body weight and inc...


    pub_type: 杂志文章


    authors: Vaiserman AM,Koshel NM,Mechova LV,Voitenko VP

    更新日期:2004-01-01 00:00:00

  • Bridging the gap between the laboratory and the clinic for patients with sarcopenia.

    abstract::Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...


    pub_type: 杂志文章


    authors: Witham MD

    更新日期:2019-04-01 00:00:00

  • An evolutionary heterogeneity model of late-life fecundity in Drosophila.

    abstract::There is now a significant body of research that establishes the deceleration of mortality rates in late life and their ultimate leveling off on a late-life plateau. Natural selection has been offered as one mechanism responsible for these plateaus. The force of natural selection should also exert such effects on fema...


    pub_type: 杂志文章


    authors: Mueller LD,Rauser CL,Rose MR

    更新日期:2007-04-01 00:00:00

  • Long-term dietary restriction differentially affects the expression of BDNF and its receptors in the cortex and hippocampus of middle-aged and aged male rats.

    abstract::Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related diseases in many organisms including humans. The present study aimed to examine the influence of long-term DR on the BDNF system at the transcriptional and translational levels in the cortex and hippocampus of middle-aged ...


    pub_type: 杂志文章


    authors: Smiljanic K,Pesic V,Mladenovic Djordjevic A,Pavkovic Z,Brkic M,Ruzdijic S,Kanazir S

    更新日期:2015-02-01 00:00:00

  • Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway.

    abstract::The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information regarding the mechanistic role of EGCG in the suppression of cellular senescence is limited. The present study thus assessed the effects and underlying mechanisms...


    pub_type: 杂志文章


    authors: Kumar R,Sharma A,Kumari A,Gulati A,Padwad Y,Sharma R

    更新日期:2019-04-01 00:00:00