Pathways defective in the human premature aging disease Werner syndrome.

abstract：:Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...

journal_title：Biogerontology

authors： Augustyniak J,Lenart J,Zychowicz M,Stepien PP,Buzanska L

更新日期：2017-08-01 00:00:00

abstract：:In mammals suprachiasmatic nucleus (SCN), acts as a light entrainable master clock and by generation of temporal oscillations regulates the peripheral organs acting as autonomous clocks resulting in overt behavioral and physiological rhythms. SCN also controls synthesis and release of melatonin (hormonal message for d...

journal_title：Biogerontology

authors： Vinod C,Jagota A

更新日期：2016-11-01 00:00:00

abstract：:In this study, we have assessed the impact of vitamin E and exercise on acquisition and retention of spatial memory for a given task in aging rats, using a T-maze. Acetylcholine esterase (AChE) and cholineacetyl transferase (ChAT) activities and acetylcholine (ACh) were measured in the cerebral cortex (CC) of male Wis...

journal_title：Biogerontology

authors： Jolitha AB,Subramanyam MV,Asha Devi S

更新日期：2009-02-01 00:00:00

abstract：:Evolutionary theory leads to the general expectation that dietary restriction will often result in increased survival probabilities, and thus increased lifespan. The reaction norm is a basic tool of evolutionary analysis that quantifies the relationship between environmental parameters and functional characters, inclu...

journal_title：Biogerontology

authors： Phelan JP,Rose MR

更新日期：2006-06-01 00:00:00

abstract：:Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven by highly conserved cell intrinsic processes, and a set of unifying hallmarks of ageing has been defined. Here, we survey reports of age-l...

journal_title：Biogerontology

authors： Frenk S,Houseley J

更新日期：2018-12-01 00:00:00

abstract：:Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...

journal_title：Biogerontology

authors： Sipilä S,Narici M,Kjaer M,Pöllänen E,Atkinson RA,Hansen M,Kovanen V

更新日期：2013-06-01 00:00:00

abstract：:Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...

journal_title：Biogerontology

authors： Arbeev KG,Ukraintseva SV,Arbeeva LS,Akushevich I,Kulminski AM,Yashin AI

更新日期：2011-04-01 00:00:00

abstract：:Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...

journal_title：Biogerontology

authors： Unterluggauer H,Hütter E,Voglauer R,Grillari J,Vöth M,Bereiter-Hahn J,Jansen-Dürr P,Jendrach M

更新日期：2007-08-01 00:00:00

abstract：:Melatonin synthesis is disordered in patients with Alzheimer's disease (AD). To determine the role of melatonin in the pathogenesis of AD, suitable animal models are needed. The OXYS rats are an experimental model of accelerated senescence that has also been proposed as a spontaneous rat model of AD-like pathology. In...

journal_title：Biogerontology

authors： Rudnitskaya EA,Maksimova KY,Muraleva NA,Logvinov SV,Yanshole LV,Kolosova NG,Stefanova NA

更新日期：2015-06-01 00:00:00

abstract：:When mortality (μ), aging rate (γ) and age (t) are treated according to the Gompertz model μ(t) = μ0eγt (GM), any mean age corresponds to a manifold of paired reciprocally changing μ0 and γ. Therefore, any noisiness of data used to derive GM parameters makes them negatively correlated. Besides this artifactual factor ...

journal_title：Biogerontology

authors： Golubev A

更新日期：2019-12-01 00:00:00

abstract：:Aging process or senescence affects the expression of a wide range of phenotypic traits throughout the life span of organisms. These traits often show modular, synergistic, and even antagonistic relationships, and are also influenced by genomic, developmental, physiological and environmental factors. The cardiovascula...

journal_title：Biogerontology

authors： Govindaraju DR,Pencina KM,Raj DS,Massaro JM,Carnes BA,D'Agostino RB

更新日期：2014-04-01 00:00:00

abstract：:eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not m...

journal_title：Biogerontology

authors： Silar P,Rossignol M,Haedens V,Derhy Z,Mazabraud A

更新日期：2000-01-01 00:00:00

abstract：:We used the Fischer 344 rat as a model for aging effects on the heart. Cardiac interfibrillar mitochondria (IFM), located between the myofibrils, exhibit a decrease in protein yield and oxidative phosphorylation through complex III and IV in elderly (24 months) compared to adult controls (6 months). In contrast, subsa...

journal_title：Biogerontology

authors： Hoppel CL,Moghaddas S,Lesnefsky EJ

更新日期：2002-01-01 00:00:00

abstract：:During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...

journal_title：Biogerontology

authors： Holliday R

更新日期：2001-01-01 00:00:00

abstract：:Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...

journal_title：Biogerontology

authors： Vaiserman A,Cuttler JM,Socol Y

更新日期：2021-01-09 00:00:00

abstract：:The sample size of the data used in genetic studies is often a factor limiting the accuracy of statistical estimates. In this paper we suggest a new approach to evaluation of genetic influence on risk of development of aging-related health disorders. The approach results in substantial improvement of the accuracy of s...

journal_title：Biogerontology

authors： Yashin AI,Arbeev KG,Ukraintseva SV

更新日期：2007-06-01 00:00:00

abstract：:There is increasing support for the notion that genetic variation for lifespan, both within and between species, is correlated with variation in the efficiency of the free radical scavenging system and the ability to withstand oxidative stress. In Drosophila, resistance to dietary paraquat, a free radical generator, i...

journal_title：Biogerontology

authors： Vermeulen CJ,Van De Zande L,Bijlsma R

更新日期：2005-12-01 00:00:00

abstract：:Adult stem cells are known to have a finite replication potential. Muscle biopsy-derived human satellite cells (SCs) were grown at different passages and differentiated to human myotubes in culture to analyze the functional state of various carbohydrate and lipid metabolic pathways. As the proliferative potential of m...

journal_title：Biogerontology

authors： Nehlin JO,Just M,Rustan AC,Gaster M

更新日期：2011-08-01 00:00:00

abstract：:Gene expression in aging kidney and pituitary was determined by subtractive hybridization, DNA microarrays and RT-PCR. Kidneys and pituitary were removed from 10- and 30-month-old female WAG/Rij rats, which were free from chronic progressive nephrosis and had a low incidence of pituitary tumors with age. From 350 cDNA...

journal_title：Biogerontology

authors： Preisser L,Houot L,Teillet L,Kortulewski T,Morel A,Tronik-Le Roux D,Corman B

更新日期：2004-01-01 00:00:00

abstract：:The long-term effects of X-irradiation with 0.25, 0.5, 0.75 and 1 Gy of 1 h eggs on the fitness-related life history traits in adult Drosophila melanogaster fruit flies and their offspring were investigated. Following irradiation with 0.25, 0.5 and 0.75 Gy, both F0 and F1 flies have decreased adult body weight and inc...

journal_title：Biogerontology

authors： Vaiserman AM,Koshel NM,Mechova LV,Voitenko VP

更新日期：2004-01-01 00:00:00

abstract：:The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...

journal_title：Biogerontology

authors： Jylhävä J,Eklund C,Jylhä M,Hervonen A,Hurme M

更新日期：2010-12-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells represent a well-established T cell lineage characterised in humans by TCR consisting of an invariant alpha chain encoded by Valpha24-JalphaQ genes, paired preferentially with a Vbeta11 chain. iNKT cells also share some characteristics with NK cells, such as the expression of th...

journal_title：Biogerontology

authors： Peralbo E,DelaRosa O,Gayoso I,Pita ML,Tarazona R,Solana R

更新日期：2006-10-01 00:00:00

abstract：:Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...

journal_title：Biogerontology

authors： Jagota A,Mattam U

更新日期：2017-08-01 00:00:00

abstract：:We studied vascular function in quiescent aortas from senescence-accelerated resistant (SAM-R1) and prone (SAM-P8) mice. Myographical studies of thoracic aorta segments from 6-7 month-old mice showed that the contractility of SAM-P8 aortas was markedly higher than that of SAM-R1 after KCl depolarization or phenylephri...

journal_title：Biogerontology

authors： Lloréns S,de Mera RM,Pascual A,Prieto-Martín A,Mendizábal Y,de Cabo C,Nava E,Jordán J

更新日期：2007-12-01 00:00:00

abstract：:Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related diseases in many organisms including humans. The present study aimed to examine the influence of long-term DR on the BDNF system at the transcriptional and translational levels in the cortex and hippocampus of middle-aged ...

journal_title：Biogerontology

authors： Smiljanic K,Pesic V,Mladenovic Djordjevic A,Pavkovic Z,Brkic M,Ruzdijic S,Kanazir S

更新日期：2015-02-01 00:00:00

abstract：:Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...

journal_title：Biogerontology

authors： Ross KS,Smith C

更新日期：2020-12-01 00:00:00

abstract：:Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...

journal_title：Biogerontology

authors： Russ DW,Boyd IM,McCoy KM,McCorkle KW

更新日期：2015-12-01 00:00:00

abstract：:An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the maintenance of homeostasis due to various endogenous and environmental challenges, leading to amassing of damages, functional deterioration of ...

journal_title：Biogerontology

authors： Mathew R,Pal Bhadra M,Bhadra U

更新日期：2017-02-01 00:00:00

abstract：:FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malo...

journal_title：Biogerontology

authors： Panchenko AV,Popovich IG,Trashkov AP,Egormin PA,Yurova MN,Tyndyk ML,Gubareva EA,Artyukin IN,Vasiliev AG,Khaitsev NV,Zabezhinski MA,Anisimov VN

更新日期：2016-04-01 00:00:00

abstract：:Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer's, dialysis related amyloidosis (DRA), atherosclerosis and Parkinson's as well as physiological aging. This review attempts to summarize the data on glycation in relation...

journal_title：Biogerontology

authors： Suji G,Sivakami S

更新日期：2004-01-01 00:00:00