Pathways defective in the human premature aging disease Werner syndrome.

Abstract:

:Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and role of this protein is discussed in the light of how it functions in the aging process.

journal_name

Biogerontology

journal_title

Biogerontology

authors

Bohr VA,Brosh RM Jr,von Kobbe C,Opresko P,Karmakar P

doi

10.1023/a:1015223917491

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

89-94

issue

1-2

eissn

1389-5729

issn

1573-6768

journal_volume

3

pub_type

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