Bridging the gap between the laboratory and the clinic for patients with sarcopenia.

Abstract:

:Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a key goal for clinical ageing research. If patients are to eventually benefit from discovery science on ageing skeletal muscle, we need to build a translational pipeline that facilitates progress from laboratory science and epidemiology, through feasibility testing to early-phase, and eventually late-phase clinical trials. A number of barriers need to be overcome to make this pipeline work-in particular challenges around identifying people with sarcopenia in routine clinical practice, ensuring that we study patients with clearly defined sarcopenia rather than related conditions such as functional impairment, developing capacity to run trials for older people, and selecting trial outcomes of relevance to older people with multimorbidity. A further key point is that interventions should ideally have pleiotropic actions-i.e. beneficial actions across multiple organ systems, rather than treating sarcopenia alone. Such pleiotropic interventions may be the only way to avoid the perils of polypharmacy and drug interactions that bedevil care for many older people. Maximising the potential for scientific discoveries in the biology of ageing muscle to improve health requires that discovery scientists, translational clinical scientists and clinicians come together to exchange findings and shape each others ideas within a shared culture.

journal_name

Biogerontology

journal_title

Biogerontology

authors

Witham MD

doi

10.1007/s10522-018-09793-z

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

241-248

issue

2

eissn

1389-5729

issn

1573-6768

pii

10.1007/s10522-018-09793-z

journal_volume

20

pub_type

杂志文章
  • Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?

    abstract::The predominant molecular symptom of ageing is the accumulation of altered gene products. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin activity. P...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-007-9110-x

    authors: Hipkiss AR

    更新日期:2008-02-01 00:00:00

  • The accuracy of statistical estimates in genetic studies of aging can be significantly improved.

    abstract::The sample size of the data used in genetic studies is often a factor limiting the accuracy of statistical estimates. In this paper we suggest a new approach to evaluation of genetic influence on risk of development of aging-related health disorders. The approach results in substantial improvement of the accuracy of s...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-006-9072-4

    authors: Yashin AI,Arbeev KG,Ukraintseva SV

    更新日期:2007-06-01 00:00:00

  • Background radiation impacts human longevity and cancer mortality: reconsidering the linear no-threshold paradigm.

    abstract::The current linear no-threshold paradigm assumes that any exposure to ionizing radiation carries some risk, thus every effort should be made to maintain the exposures as low as possible. We examined whether background radiation impacts human longevity and cancer mortality. Our data covered the entire US population of ...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-020-09909-4

    authors: David E,Wolfson M,Fraifeld VE

    更新日期:2021-01-22 00:00:00

  • Accumulation of glycated proteins suggesting premature ageing in lamin B receptor deficient mice.

    abstract::Accumulation of advanced glycation end products (AGEs) is accompanied by increased free radical activity which contributes to ageing and the development or worsening of degenerative diseases. Apart from other physiological factors, AGEs are also an important biomarker for premature ageing. Here we report protein modif...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-017-9733-5

    authors: Hause F,Schlote D,Simm A,Hoffmann K,Santos AN

    更新日期:2018-02-01 00:00:00

  • Gene expression hallmarks of cellular ageing.

    abstract::Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven by highly conserved cell intrinsic processes, and a set of unifying hallmarks of ageing has been defined. Here, we survey reports of age-l...

    journal_title:Biogerontology

    pub_type: 杂志文章,评审

    doi:10.1007/s10522-018-9750-z

    authors: Frenk S,Houseley J

    更新日期:2018-12-01 00:00:00

  • Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria.

    abstract::It is known that a global decrease in food ingestion (dietary restriction, DR) lowers mitochondrial ROS generation (mitROS) and oxidative stress in young immature rats. This seems to be caused by the decreased methionine ingestion of DR animals. This is interesting since isocaloric methionine restriction in the diet (...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-012-9384-5

    authors: Sanchez-Roman I,Gómez A,Pérez I,Sanchez C,Suarez H,Naudí A,Jové M,Lopez-Torres M,Pamplona R,Barja G

    更新日期:2012-08-01 00:00:00

  • Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner.

    abstract::Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-017-9718-4

    authors: Augustyniak J,Lenart J,Zychowicz M,Stepien PP,Buzanska L

    更新日期:2017-08-01 00:00:00

  • Decreased frequency and proliferative response of invariant Valpha24Vbeta11 natural killer T (iNKT) cells in healthy elderly.

    abstract::Invariant natural killer T (iNKT) cells represent a well-established T cell lineage characterised in humans by TCR consisting of an invariant alpha chain encoded by Valpha24-JalphaQ genes, paired preferentially with a Vbeta11 chain. iNKT cells also share some characteristics with NK cells, such as the expression of th...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-006-9063-5

    authors: Peralbo E,DelaRosa O,Gayoso I,Pita ML,Tarazona R,Solana R

    更新日期:2006-10-01 00:00:00

  • Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population.

    abstract::Associations have been reported between plasma Cu and Zn levels and the incidence of the most important age-related diseases. Previously proposed methods of using plasma Cu/Zn as a predictor of all-cause mortality have been derived from populations in which old and very old subjects were underrepresented. The purpose ...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-009-9251-1

    authors: Malavolta M,Giacconi R,Piacenza F,Santarelli L,Cipriano C,Costarelli L,Tesei S,Pierpaoli S,Basso A,Galeazzi R,Lattanzio F,Mocchegiani E

    更新日期:2010-06-01 00:00:00

  • The senescence-accelerated mouse (SAM-P8) as a model for the study of vascular functional alterations during aging.

    abstract::We studied vascular function in quiescent aortas from senescence-accelerated resistant (SAM-R1) and prone (SAM-P8) mice. Myographical studies of thoracic aorta segments from 6-7 month-old mice showed that the contractility of SAM-P8 aortas was markedly higher than that of SAM-R1 after KCl depolarization or phenylephri...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-007-9108-4

    authors: Lloréns S,de Mera RM,Pascual A,Prieto-Martín A,Mendizábal Y,de Cabo C,Nava E,Jordán J

    更新日期:2007-12-01 00:00:00

  • The secretory phenotype of senescent astrocytes isolated from Wistar newborn rats changes with anti-inflammatory drugs, but does not have a short-term effect on neuronal mitochondrial potential.

    abstract::In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescen...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-018-9767-3

    authors: Maciel-Barón LÁ,Morales-Rosales SL,Silva-Palacios A,Rodríguez-Barrera RH,García-Álvarez JA,Luna-López A,Pérez VI,Torres C,Königsberg M

    更新日期:2018-10-01 00:00:00

  • D-galactose: a model of accelerated ageing sufficiently sensitive to reflect preventative efficacy of an antioxidant treatment.

    abstract::Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-020-09891-x

    authors: Ross KS,Smith C

    更新日期:2020-12-01 00:00:00

  • From life to death--the struggle between chemistry and biology during aging: the Maillard reaction as an amplifier of genomic damage.

    abstract::Biogerontology is the study of the aging of biological systems. This review addresses the relationship between chemistry and biology during aging, proposing that chemistry is responsible for the aging of biological systems. In the continuing struggle between chemistry and biology, chemistry is always the short-term, t...

    journal_title:Biogerontology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1010034213093

    authors: Baynes JW

    更新日期:2000-01-01 00:00:00

  • Effect of chronic treatments with GH, melatonin, estrogens, and phytoestrogens on oxidative stress parameters in liver from aged female rats.

    abstract::The aging theory postulates that this process may be due to the accumulation of oxidative damage in cells and molecules. The present study has investigated the effect of castration in old female rats on various parameters related to the antioxidant properties of several cellular fractions obtained from the liver, and ...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-007-9089-3

    authors: Kireev RA,Tresguerres AF,Vara E,Ariznavarreta C,Tresguerres JA

    更新日期:2007-10-01 00:00:00

  • The NetAge database: a compendium of networks for longevity, age-related diseases and associated processes.

    abstract::Hundreds of genes and miRNAs have been identified as being involved in the determination of longevity, aging patterns and in the development of age-related diseases (ARDs). The interplay between these genes as well as the role of miRNAs in the context of protein-protein interaction networks has as yet been poorly addr...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-010-9265-8

    authors: Tacutu R,Budovsky A,Fraifeld VE

    更新日期:2010-08-01 00:00:00

  • Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.

    abstract::Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-017-9711-y

    authors: Jagota A,Mattam U

    更新日期:2017-08-01 00:00:00

  • Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart.

    abstract::The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated b...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-005-7950-9

    authors: Rohrbach S,Simm A,Pregla R,Franke C,Katschinski DM

    更新日期:2005-01-01 00:00:00

  • Oxidative stress and intracellular pH in the young and old erythrocytes of rat.

    abstract::The effects of oxidative stress (OS) on the rat erythrocytes (RBCs) that were fractionated on the percoll/BSA gradient into young and old cells were studied to find out if the altered Na+/H+ and Cl⁻/ HCO3⁻ antiporters and in turn the intracellular pH (pHi) could act as one of the promoters of cell death. Old cells wer...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-009-9212-8

    authors: Asha Devi S,Shiva Shankar Reddy CS,Subramanyam MV

    更新日期:2009-12-01 00:00:00

  • Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness.

    abstract::Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. ...

    journal_title:Biogerontology

    pub_type: 杂志文章,评审

    doi:10.1007/s10522-008-9131-0

    authors: Ryall JG,Schertzer JD,Lynch GS

    更新日期:2008-08-01 00:00:00

  • Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data.

    abstract::Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-010-9316-1

    authors: Arbeev KG,Ukraintseva SV,Arbeeva LS,Akushevich I,Kulminski AM,Yashin AI

    更新日期:2011-04-01 00:00:00

  • Age-dependent differential expression and activity of rat liver cytosolic inorganic pyrophosphatase gene.

    abstract::Besides epigenetic factors, the genetic make-up and differential gene expression not only determines aging and disease susceptibility but also the functional activity of cells in an individual. Analysis of a variety of mammalian tissues revealed that the age-associated differentially expressed genes mainly belong to i...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-007-9094-6

    authors: Panda H,Pandey RS,Debata PR,Supakar PC

    更新日期:2007-10-01 00:00:00

  • A mild stress due to hypergravity exposure at young age increases longevity in Drosophila melanogaster males.

    abstract::Drosophila melanogaster flies were exposed to hypergravity starting at two days of age, the range of gravity levels used being 2.58-7.38 g. No longevity change was observed for exposures of less than 14 days. The longevity of males increased if they were submitted to hypergravity for durations ranging from 14 to 24 da...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1023/a:1010043914016

    authors: Le Bourg E,Minois N,Bullens P,Baret P

    更新日期:2000-01-01 00:00:00

  • Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages.

    abstract::Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-008-9164-4

    authors: Ito Y,Betsuyaku T,Moriyama C,Nasuhara Y,Nishimura M

    更新日期:2009-04-01 00:00:00

  • Daily NO rhythms in peripheral clocks in aging male Wistar rats: protective effects of exogenous melatonin.

    abstract::In mammals suprachiasmatic nucleus (SCN), acts as a light entrainable master clock and by generation of temporal oscillations regulates the peripheral organs acting as autonomous clocks resulting in overt behavioral and physiological rhythms. SCN also controls synthesis and release of melatonin (hormonal message for d...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-016-9656-6

    authors: Vinod C,Jagota A

    更新日期:2016-11-01 00:00:00

  • Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species.

    abstract::An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the maintenance of homeostasis due to various endogenous and environmental challenges, leading to amassing of damages, functional deterioration of ...

    journal_title:Biogerontology

    pub_type: 杂志文章,评审

    doi:10.1007/s10522-016-9670-8

    authors: Mathew R,Pal Bhadra M,Bhadra U

    更新日期:2017-02-01 00:00:00

  • Age-related changes in the response of rat adipocytes to insulin: evidence for a critical role for inositol phosphoglycans and cAMP.

    abstract::Adipose tissue plays a pivotal role in ageing and longevity; many studies, both human and animal, have focussed on the effects of food limitation. Here we present a new model based on striking differences between two 'normal' inbred strains of albino Wistar rats the Charles River (CR) and Harlan Olac (HO) that have ma...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-010-9271-x

    authors: Kunjara S,Greenbaum AL,Rademacher TW,McLean P

    更新日期:2010-08-01 00:00:00

  • Modulation of aging profiles in isogenic populations of Caenorhabditis elegans by bacteria causing different extrinsic mortality rates.

    abstract::It has been postulated that the presence of parasites causing high extrinsic mortality may trigger an inducible acceleration of the host aging. We tested this hypothesis using isogenic populations of Caenorhabditis elegans nematodes and different Escherichia coli strains. When exposed to pathogenic bacteria, nematodes...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-009-9228-0

    authors: Baeriswyl S,Diard M,Mosser T,Leroy M,Manière X,Taddei F,Matic I

    更新日期:2010-02-01 00:00:00

  • Age-related responses of the rat cerebral cortex: influence of vitamin E and exercise on the cholinergic system.

    abstract::In this study, we have assessed the impact of vitamin E and exercise on acquisition and retention of spatial memory for a given task in aging rats, using a T-maze. Acetylcholine esterase (AChE) and cholineacetyl transferase (ChAT) activities and acetylcholine (ACh) were measured in the cerebral cortex (CC) of male Wis...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-008-9154-6

    authors: Jolitha AB,Subramanyam MV,Asha Devi S

    更新日期:2009-02-01 00:00:00

  • Identification of cultivation-independent markers of human endothelial cell senescence in vitro.

    abstract::Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-007-9082-x

    authors: Unterluggauer H,Hütter E,Voglauer R,Grillari J,Vöth M,Bereiter-Hahn J,Jansen-Dürr P,Jendrach M

    更新日期:2007-08-01 00:00:00

  • Age-specificity and the evolution of senescence: a discussion.

    abstract::Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...

    journal_title:Biogerontology

    pub_type: 杂志文章

    doi:10.1007/s10522-012-9410-7

    authors: Wensink M

    更新日期:2013-02-01 00:00:00