Abstract：
:Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within the European large scale MYOAGE project, the role of sex hormones, estrogens and testosterone, in causing the aging-related loss of muscle mass and function was further investigated. Hormone replacement therapy (HRT) in women is shown to diminish age-associated muscle loss, loss in fast muscle function (power), and accumulation of fat in skeletal muscle. Further HRT raises the protein synthesis rate in skeletal muscle after resistance training, and has an anabolic effect upon connective tissue in both skeletal muscle and tendon, which influences matrix structure and mechanical properties. HRT influences gene expression in e.g. cytoskeletal and cell-matrix proteins, has a stimulating effect upon IGF-I, and a role in IL-6 and adipokine regulation. Despite low circulating steroid-hormone level, postmenopausal women have a high local concentration of steroidogenic enzymes in skeletal muscle.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Sipilä S,Narici M,Kjaer M,Pöllänen E,Atkinson RA,Hansen M,Kovanen Vdoi
10.1007/s10522-013-9425-8subject
Has Abstractpub_date
2013-06-01 00:00:00pages
231-45issue
3eissn
1389-5729issn
1573-6768journal_volume
14pub_type
杂志文章,评审相关文献
BIOGERONTOLOGY文献大全abstract：:The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-020-09861-3
更新日期：2020-06-01 00:00:00
abstract：:Sarcopenia, defined as the age-related loss of muscle mass, subsequently has a negative effect on strength, metabolic rate and functionality leading to a reduced quality of life. With the projected increase in life expectancy, the incidence of muscle loss may rise and further drain the health care system, with greater...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-011-9327-6
更新日期：2011-08-01 00:00:00
abstract：:Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9164-4
更新日期：2009-04-01 00:00:00
abstract：:Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-007-9082-x
更新日期：2007-08-01 00:00:00
abstract：:Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-020-09891-x
更新日期：2020-12-01 00:00:00
abstract：:The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-020-09867-x
更新日期：2020-06-01 00:00:00
abstract：:Previously, extremely low, nanomolar concentrations of the mitochondria-targeted plastoquinone derivative SkQ1 (10-(6'-plastoquinonyl) decyltriphenylphosphonium) were shown to prolong the lifespan of male and female Drosophila melanogaster by about 10 % (Anisimov et al., Biochemistry (Moscow) 73:1329-1342, 2008). Usin...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-012-9404-5
更新日期：2012-12-01 00:00:00
abstract：:Researchers working in the area of ageing have found numerous manifestations of this process at the molecular biological level, including DNA and protein damage, accumulation of metabolic by-products, lipids peroxidation, macromolecular cross-linking, non-enzymatic glycosylation, anti-oxidant/pro-oxidant misbalance, r...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-017-9728-2
更新日期：2018-02-01 00:00:00
abstract：:FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malo...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-015-9611-y
更新日期：2016-04-01 00:00:00
abstract：:For a period of 6-15 days prior to death, the fecundity and virility of Drosophila melanogaster fall significantly below those of same-aged flies that are not near death. It is likely that other aspects of physiology may decline during this period. This study attempts to document changes in two physiological character...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-012-9398-z
更新日期：2012-10-01 00:00:00
abstract：:We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-019-09848-9
更新日期：2020-04-01 00:00:00
abstract：:In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescen...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-018-9767-3
更新日期：2018-10-01 00:00:00
abstract：:In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade. Identifying and...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-014-9527-y
更新日期：2015-04-01 00:00:00
abstract：:An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the maintenance of homeostasis due to various endogenous and environmental challenges, leading to amassing of damages, functional deterioration of ...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-016-9670-8
更新日期：2017-02-01 00:00:00
abstract：:Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer's, dialysis related amyloidosis (DRA), atherosclerosis and Parkinson's as well as physiological aging. This review attempts to summarize the data on glycation in relation...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-004-3189-0
更新日期：2004-01-01 00:00:00
abstract：:Besides epigenetic factors, the genetic make-up and differential gene expression not only determines aging and disease susceptibility but also the functional activity of cells in an individual. Analysis of a variety of mammalian tissues revealed that the age-associated differentially expressed genes mainly belong to i...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-007-9094-6
更新日期：2007-10-01 00:00:00
abstract：:Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-012-9399-y
更新日期：2012-10-01 00:00:00
abstract：:Histone post-translational modifications (PTMs) are involved in diverse biological processes and methylation was regarded as a long-term epigenetic mark. Though aging represented one of the major risk factors for neurodegenerative diseases, no systematic investigations had correlated the patterns of histone PTMs in th...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-009-9231-5
更新日期：2010-02-01 00:00:00
abstract：:High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complex...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-018-9752-x
更新日期：2018-12-01 00:00:00
abstract：:Aging is associated with accumulation of toxic intracellular and extracellular protein aggregates. Cells manage "aged" proteins by mobilizing their molecular chaperones or heat shock proteins that are also considered as determinants of lifespan in diverse species. In this study, we tested whether an exogenous addition...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9136-8
更新日期：2008-08-01 00:00:00
abstract：:Death-associated protein 6 (DAXX) is a ubiquitous protein implicated in various cellular processes such as apoptosis, tumorigenesis, development and transcription. The role of DAXX is however ambiguous and many contradictory results regarding its function in apoptosis upon various cellular stresses are described in th...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-016-9651-y
更新日期：2016-11-01 00:00:00
abstract：:CD4+ T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4+ T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearanc...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-018-9754-8
更新日期：2018-12-01 00:00:00
abstract：:Sarcopenia, characterized by profound muscle atrophy and the loss of contractile function, contributes significantly to the development of frailty and functional impairment in older age. Although present in aging humans, rat models have failed to clearly demonstrate a similar degree of this age-associated loss of musc...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-005-4808-0
更新日期：2005-01-01 00:00:00
abstract：:Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9316-1
更新日期：2011-04-01 00:00:00
abstract：:Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. ...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-008-9131-0
更新日期：2008-08-01 00:00:00
abstract：:Prophylaxis with vaccines is important in geriatrics as, apart from specific protection, it reduces incidence of potentially fatal infectious complications and exacerbations of existing medical conditions. Post-vaccination protection depends on immunity and therefore markers of immune status could be used to predict e...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9155-5
更新日期：2009-02-01 00:00:00
abstract：:Two sibling Drosophila species dramatically divergent in longevity, Drosophila buzzatii and D. koepferae, were examined for possible effects of both developmental culture medium and dietary composition (DC) on longevity. Longevity was greatly increased in the longer lived D. buzzatii when flies were reared and fed on ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-013-9441-8
更新日期：2013-08-01 00:00:00
abstract：:Accumulation of advanced glycation end products (AGEs) is accompanied by increased free radical activity which contributes to ageing and the development or worsening of degenerative diseases. Apart from other physiological factors, AGEs are also an important biomarker for premature ageing. Here we report protein modif...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-017-9733-5
更新日期：2018-02-01 00:00:00
abstract：:An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-019-09801-w
更新日期：2019-06-01 00:00:00
abstract：:Melatonin synthesis is disordered in patients with Alzheimer's disease (AD). To determine the role of melatonin in the pathogenesis of AD, suitable animal models are needed. The OXYS rats are an experimental model of accelerated senescence that has also been proposed as a spontaneous rat model of AD-like pathology. In...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-014-9547-7
更新日期：2015-06-01 00:00:00
