Abstract:
:Two sibling Drosophila species dramatically divergent in longevity, Drosophila buzzatii and D. koepferae, were examined for possible effects of both developmental culture medium and dietary composition (DC) on longevity. Longevity was greatly increased in the longer lived D. buzzatii when flies were reared and fed on a rich-in-nutrient and cactus-based culture (R-CBC) as compared to longevity in a poor nutrient culture (PNC). In D. buzzatii, life span was further increased by exposing flies to short periods of a poor-in-nutrient and cactus-based culture (P-CBC). In contrast, variation in the here used nutrient composition did not change life span in the shorter lived D. koepferae, as longevity in this species did not differ among R-CBC, P-CBC and PNC cultures. Hormesis is a plausible explanation for the beneficial biological effects against aging arising from brief exposure to a lowed calorie food source in D. buzzatii. This study shows that genetic variation between closely related species is substantial for dietary effects on longevity.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Gomez FH,Sambucetti P,Norry FMdoi
10.1007/s10522-013-9441-8subject
Has Abstractpub_date
2013-08-01 00:00:00pages
423-9issue
4eissn
1389-5729issn
1573-6768journal_volume
14pub_type
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