Reliability and variability of sleep and activity as biomarkers of ageing in Drosophila.

abstract：:The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated b...

journal_title：Biogerontology

authors： Rohrbach S,Simm A,Pregla R,Franke C,Katschinski DM

更新日期：2005-01-01 00:00:00

abstract：:The mutation level (chromosome aberrations covering telomere regions), modifications of chromosome structure (level of condensed chromatin identified by the methods of electron microscopy and differential scanning microcalorimetry; level of C-banding constitutive heterochromatin; transcriptional activity of DNA-depend...

journal_title：Biogerontology

authors： Lezhava T

更新日期：2001-01-01 00:00:00

abstract：:Obesity is associated with functional limitations in muscle performance and increased likelihood of developing a functional disability such as mobility, strength, postural and dynamic balance limitations. The consensus is that obese individuals, regardless of age, have a greater absolute maximum muscle strength compar...

journal_title：Biogerontology

authors： Tomlinson DJ,Erskine RM,Morse CI,Winwood K,Onambélé-Pearson G

更新日期：2016-06-01 00:00:00

abstract：:Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...

journal_title：Biogerontology

authors： Rolt A,Nair A,Cox LS

更新日期：2019-06-01 00:00:00

abstract：:Evolutionary theory leads to the general expectation that dietary restriction will often result in increased survival probabilities, and thus increased lifespan. The reaction norm is a basic tool of evolutionary analysis that quantifies the relationship between environmental parameters and functional characters, inclu...

journal_title：Biogerontology

authors： Phelan JP,Rose MR

更新日期：2006-06-01 00:00:00

abstract：:Biogerontology is the study of the aging of biological systems. This review addresses the relationship between chemistry and biology during aging, proposing that chemistry is responsible for the aging of biological systems. In the continuing struggle between chemistry and biology, chemistry is always the short-term, t...

journal_title：Biogerontology

authors： Baynes JW

更新日期：2000-01-01 00:00:00

abstract：:Accumulating studies have argued that the mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that promotes longevity in model organisms. In the present study, we screened an off-patent drug library to identify compounds that activate UPRmt using a mitochondrial chaperone hsp-6::GFP repo...

journal_title：Biogerontology

authors： Ito A,Zhao Q,Tanaka Y,Yasui M,Katayama R,Sun S,Tanimoto Y,Nishikawa Y,Kage-Nakadai E

更新日期：2021-02-01 00:00:00

abstract：:Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...

journal_title：Biogerontology

authors： Sipilä S,Narici M,Kjaer M,Pöllänen E,Atkinson RA,Hansen M,Kovanen V

更新日期：2013-06-01 00:00:00

abstract：:Oxidative stress caused by reactive oxygen species is proposed to cause age related muscle wasting (sarcopenia). Reversible oxidation of protein thiols by reactive oxygen species can affect protein function, so we evaluated whether muscle wasting in normal aging was associated with a pervasive increase in reversible o...

journal_title：Biogerontology

authors： Tohma H,El-Shafey AF,Croft K,Shavlakadze T,Grounds MD,Arthur PG

更新日期：2014-02-01 00:00:00

abstract：:During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...

journal_title：Biogerontology

authors： Böttner M,Leonhardt S,Wuttke W,Wedel T,Jarry H

更新日期：2010-02-01 00:00:00

abstract：:Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...

journal_title：Biogerontology

authors： Unterluggauer H,Hütter E,Voglauer R,Grillari J,Vöth M,Bereiter-Hahn J,Jansen-Dürr P,Jendrach M

更新日期：2007-08-01 00:00:00

abstract：:There is now a significant body of research that establishes the deceleration of mortality rates in late life and their ultimate leveling off on a late-life plateau. Natural selection has been offered as one mechanism responsible for these plateaus. The force of natural selection should also exert such effects on fema...

journal_title：Biogerontology

authors： Mueller LD,Rauser CL,Rose MR

更新日期：2007-04-01 00:00:00

abstract：:We studied vascular function in quiescent aortas from senescence-accelerated resistant (SAM-R1) and prone (SAM-P8) mice. Myographical studies of thoracic aorta segments from 6-7 month-old mice showed that the contractility of SAM-P8 aortas was markedly higher than that of SAM-R1 after KCl depolarization or phenylephri...

journal_title：Biogerontology

authors： Lloréns S,de Mera RM,Pascual A,Prieto-Martín A,Mendizábal Y,de Cabo C,Nava E,Jordán J

更新日期：2007-12-01 00:00:00

abstract：:Calorie restriction (CR) extends lifespan in a remarkable range of organisms. However, the mechanisms of CR related to the longevity effects are not fully elucidated to date. Using human fibroblast Hs68 (Hs68) cells cultured at a lower level of medium glucose (i.e., glucose restriction; GR) to mimic CR, we investigate...

journal_title：Biogerontology

authors： Yang NC,Song TY,Chang YZ,Chen MY,Hu ML

更新日期：2015-02-01 00:00:00

abstract：:Inflammation is an underlying basis for the molecular alterations that link aging and age-related pathological processes. In a previous study, we found that secretory phospholipase A(2) (sPLA(2)) induced cellular senescence in human dermal fibroblasts (HDFs). To further investigate the association of inflammation with...

journal_title：Biogerontology

authors： Yang HH,Kim C,Jung B,Kim KS,Kim JR

更新日期：2011-06-01 00:00:00

abstract：:An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...

journal_title：Biogerontology

authors： Xia J,Gravato-Nobre M,Ligoxygakis P

更新日期：2019-06-01 00:00:00

abstract：:Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and...

journal_title：Biogerontology

authors： Bohr VA,Brosh RM Jr,von Kobbe C,Opresko P,Karmakar P

更新日期：2002-01-01 00:00:00

abstract：:Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...

journal_title：Biogerontology

authors： Augustyniak J,Lenart J,Zychowicz M,Stepien PP,Buzanska L

更新日期：2017-08-01 00:00:00

abstract：:Regular exercise is an important part of a healthy lifestyle, as it helps maintain a healthy weight and reduces the risk of chronic diseases. We explored the effects of lifelong exercise and aging on rat metabolism through a metabolomics approach. Thirty-six rats were divided into four equal groups: exercise during th...

journal_title：Biogerontology

authors： Tzimou A,Benaki D,Nikolaidis S,Mikros E,Taitzoglou I,Mougios V

更新日期：2020-10-01 00:00:00

abstract：:Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young...

journal_title：Biogerontology

authors： Srivastava D,Arya U,SoundaraRajan T,Dwivedi H,Kumar S,Subramaniam JR

更新日期：2008-10-01 00:00:00

abstract：:Ageing can have profound effects on the post-mitotic organ of behaviour, the brain. As yet the precise causes of these deleterious effects are unknown. However, clear insights into the putative mechanisms and consequences of ageing in the CNS have been achieved through the use of invertebrate models. It is now clear t...

journal_title：Biogerontology

authors： Yeoman MS,Faragher RG

更新日期：2001-01-01 00:00:00

abstract：:The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...

journal_title：Biogerontology

authors： Liu HW,Chang YC,Chan YC,Hu SH,Liu MY,Chang SJ

更新日期：2020-06-01 00:00:00

abstract：:FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malo...

journal_title：Biogerontology

authors： Panchenko AV,Popovich IG,Trashkov AP,Egormin PA,Yurova MN,Tyndyk ML,Gubareva EA,Artyukin IN,Vasiliev AG,Khaitsev NV,Zabezhinski MA,Anisimov VN

更新日期：2016-04-01 00:00:00

abstract：:With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotei...

journal_title：Biogerontology

authors： Gee JR,Ding Q,Keller JN

更新日期：2006-04-01 00:00:00

abstract：:The sample size of the data used in genetic studies is often a factor limiting the accuracy of statistical estimates. In this paper we suggest a new approach to evaluation of genetic influence on risk of development of aging-related health disorders. The approach results in substantial improvement of the accuracy of s...

journal_title：Biogerontology

authors： Yashin AI,Arbeev KG,Ukraintseva SV

更新日期：2007-06-01 00:00:00

abstract：:Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the...

journal_title：Biogerontology

authors： Costarelli L,Giacconi R,Malavolta M,Basso A,Piacenza F,Provinciali M,Maggio MG,Corsonello A,Lattanzio F

更新日期：2017-04-01 00:00:00

abstract：:Accumulation of advanced glycation end products (AGEs) is accompanied by increased free radical activity which contributes to ageing and the development or worsening of degenerative diseases. Apart from other physiological factors, AGEs are also an important biomarker for premature ageing. Here we report protein modif...

journal_title：Biogerontology

authors： Hause F,Schlote D,Simm A,Hoffmann K,Santos AN

更新日期：2018-02-01 00:00:00

abstract：:High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complex...

journal_title：Biogerontology

authors： Ezcurra M

更新日期：2018-12-01 00:00:00

abstract：:In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to s...

journal_title：Biogerontology

authors： Zole E,Ranka R

更新日期：2018-07-01 00:00:00

abstract：:Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in a...

journal_title：Biogerontology

authors： Yanai H,Budovsky A,Tacutu R,Fraifeld VE

更新日期：2011-12-01 00:00:00