Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice.

abstract：:The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...

journal_title：Biogerontology

authors： Jylhävä J,Eklund C,Jylhä M,Hervonen A,Hurme M

更新日期：2010-12-01 00:00:00

abstract：:Chronic oxidative stress plays a central role in the pathogenesis of many diseases, including HIV-1 associated disorders. Concomitantly with the decline of endogenous antioxidant systems, it was reported that HIV-1-related proteins increase the production of radical species in cells and tissues that are not directly i...

journal_title：Biogerontology

authors： Davinelli S,Scapagnini G,Denaro F,Calabrese V,Benedetti F,Krishnan S,Curreli S,Bryant J,Zella D

更新日期：2014-01-01 00:00:00

abstract：:Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...

journal_title：Biogerontology

authors： Augustyniak J,Lenart J,Zychowicz M,Stepien PP,Buzanska L

更新日期：2017-08-01 00:00:00

abstract：:Histone post-translational modifications (PTMs) are involved in diverse biological processes and methylation was regarded as a long-term epigenetic mark. Though aging represented one of the major risk factors for neurodegenerative diseases, no systematic investigations had correlated the patterns of histone PTMs in th...

journal_title：Biogerontology

authors： Wang CM,Tsai SN,Yew TW,Kwan YW,Ngai SM

更新日期：2010-02-01 00:00:00

abstract：:Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young...

journal_title：Biogerontology

authors： Srivastava D,Arya U,SoundaraRajan T,Dwivedi H,Kumar S,Subramaniam JR

更新日期：2008-10-01 00:00:00

abstract：:In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade. Identifying and...

journal_title：Biogerontology

authors： Tullet JM

更新日期：2015-04-01 00:00:00

abstract：:Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. ...

journal_title：Biogerontology

authors： Ryall JG,Schertzer JD,Lynch GS

更新日期：2008-08-01 00:00:00

abstract：:An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...

journal_title：Biogerontology

authors： Xia J,Gravato-Nobre M,Ligoxygakis P

更新日期：2019-06-01 00:00:00

abstract：:Associations have been reported between plasma Cu and Zn levels and the incidence of the most important age-related diseases. Previously proposed methods of using plasma Cu/Zn as a predictor of all-cause mortality have been derived from populations in which old and very old subjects were underrepresented. The purpose ...

journal_title：Biogerontology

authors： Malavolta M,Giacconi R,Piacenza F,Santarelli L,Cipriano C,Costarelli L,Tesei S,Pierpaoli S,Basso A,Galeazzi R,Lattanzio F,Mocchegiani E

更新日期：2010-06-01 00:00:00

abstract：:During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...

journal_title：Biogerontology

authors： Böttner M,Leonhardt S,Wuttke W,Wedel T,Jarry H

更新日期：2010-02-01 00:00:00

abstract：:Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven by highly conserved cell intrinsic processes, and a set of unifying hallmarks of ageing has been defined. Here, we survey reports of age-l...

journal_title：Biogerontology

authors： Frenk S,Houseley J

更新日期：2018-12-01 00:00:00

abstract：:A reduced adaptation to cold is a prominent feature in aged mammals, including humans. The accelerated senescence-prone strain of mice (SAMP) has been studied as an animal model for several age-associated disorders and in the acceleration of senescence. Recent studies revealed that SAMP strains have dysfunctional hype...

journal_title：Biogerontology

authors： Yamashita Y,Chiba Y,Xia C,Hirayoshi K,Satoh M,Saitoh Y,Shimada A,Nakamura E,Hosokawa M

更新日期：2005-01-01 00:00:00

abstract：:Aging process or senescence affects the expression of a wide range of phenotypic traits throughout the life span of organisms. These traits often show modular, synergistic, and even antagonistic relationships, and are also influenced by genomic, developmental, physiological and environmental factors. The cardiovascula...

journal_title：Biogerontology

authors： Govindaraju DR,Pencina KM,Raj DS,Massaro JM,Carnes BA,D'Agostino RB

更新日期：2014-04-01 00:00:00

abstract：:Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...

journal_title：Biogerontology

authors： Vaiserman A,Cuttler JM,Socol Y

更新日期：2021-01-09 00:00:00

abstract：:In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescen...

journal_title：Biogerontology

authors： Maciel-Barón LÁ,Morales-Rosales SL,Silva-Palacios A,Rodríguez-Barrera RH,García-Álvarez JA,Luna-López A,Pérez VI,Torres C,Königsberg M

更新日期：2018-10-01 00:00:00

abstract：:With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotei...

journal_title：Biogerontology

authors： Gee JR,Ding Q,Keller JN

更新日期：2006-04-01 00:00:00

abstract：:High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complex...

journal_title：Biogerontology

authors： Ezcurra M

更新日期：2018-12-01 00:00:00

abstract：:The theory that accumulation of reactive oxygen species (ROS) in internal organs is a major promoter of aging has been considered negatively. However, it is still controversial whether overexpression of superoxide dismutases (SODs), which remove ROS, extends the lifespan in Drosophila adults. We examined whether ROS a...

journal_title：Biogerontology

authors： Oka S,Hirai J,Yasukawa T,Nakahara Y,Inoue YH

更新日期：2015-08-01 00:00:00

abstract：:Menopause marks the end of the reproductive life span of women and is characterized by a dramatic drop of circulating estrogen. Hormone replacement therapy (HRT) has been successfully used to treat the symptoms of menopause because estrogen has strong suppressive effects on climacteric complaints. As the hypothalamo-p...

journal_title：Biogerontology

authors： Böttner M,Wuttke W

更新日期：2005-01-01 00:00:00

abstract：:Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...

journal_title：Biogerontology

authors： Witham MD

更新日期：2019-04-01 00:00:00

abstract：:The effects of oxidative stress (OS) on the rat erythrocytes (RBCs) that were fractionated on the percoll/BSA gradient into young and old cells were studied to find out if the altered Na+/H+ and Cl⁻/ HCO3⁻ antiporters and in turn the intracellular pH (pHi) could act as one of the promoters of cell death. Old cells wer...

journal_title：Biogerontology

authors： Asha Devi S,Shiva Shankar Reddy CS,Subramanyam MV

更新日期：2009-12-01 00:00:00

abstract：:Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...

journal_title：Biogerontology

authors： Ito Y,Betsuyaku T,Moriyama C,Nasuhara Y,Nishimura M

更新日期：2009-04-01 00:00:00

abstract：:With advancing age, memory declines through different mechanisms including dysregulation of expression of synaptic plasticity genes in hippocampus. Increasing evidences suggest that these synaptic plasticity genes are regulated through epigenetic modifications. Recently we have reported that the neuronal immediate ear...

journal_title：Biogerontology

authors： Kushwaha A,Thakur MK

更新日期：2020-04-01 00:00:00

abstract：:The long-term effects of X-irradiation with 0.25, 0.5, 0.75 and 1 Gy of 1 h eggs on the fitness-related life history traits in adult Drosophila melanogaster fruit flies and their offspring were investigated. Following irradiation with 0.25, 0.5 and 0.75 Gy, both F0 and F1 flies have decreased adult body weight and inc...

journal_title：Biogerontology

authors： Vaiserman AM,Koshel NM,Mechova LV,Voitenko VP

更新日期：2004-01-01 00:00:00

abstract：:We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not ...

journal_title：Biogerontology

authors： Tolstun DA,Knyazer A,Tushynska TV,Dubiley TA,Bezrukov VV,Fraifeld VE,Muradian KK

更新日期：2020-04-01 00:00:00

abstract：:Cell senescence, a state of cell cycle arrest and altered metabolism with enhanced pro-inflammatory secretion, underlies at least some aspects of organismal ageing. The sirtuin family of deacetylases has been implicated in preventing premature ageing; sirtuin overexpression or resveratrol-mediated activation of sirtui...

journal_title：Biogerontology

authors： Walters HE,Cox LS

更新日期：2019-06-01 00:00:00

abstract：:Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...

journal_title：Biogerontology

authors： Wensink M

更新日期：2013-02-01 00:00:00

abstract：:We propose a "protein and energy" free radical model of aging that predicts patterns of survival and fertility curves for Mediterranean fruit flies. Mathematical and simulation models of individual physiological processes were constructed in terms of stochastic differential equations. The free radical theory of aging ...

journal_title：Biogerontology

authors： Butov AA,Carey JR,Volkov MA,Sehl ME,Yashin AI

更新日期：2003-01-01 00:00:00

abstract：:Ageing can have profound effects on the post-mitotic organ of behaviour, the brain. As yet the precise causes of these deleterious effects are unknown. However, clear insights into the putative mechanisms and consequences of ageing in the CNS have been achieved through the use of invertebrate models. It is now clear t...

journal_title：Biogerontology

authors： Yeoman MS,Faragher RG

更新日期：2001-01-01 00:00:00

abstract：:Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in a...

journal_title：Biogerontology

authors： Yang LW,Song M,Li YL,Liu YP,Liu C,Han L,Wang ZH,Zhang W,Xing YQ,Zhong M

更新日期：2019-04-01 00:00:00