Chronic treatment with low doses of estradiol affects pituitary and thyroid function in young and middle-aged ovariectomized rats.

abstract：:Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...

journal_title：Biogerontology

authors： Arbeev KG,Ukraintseva SV,Arbeeva LS,Akushevich I,Kulminski AM,Yashin AI

更新日期：2011-04-01 00:00:00

abstract：:Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bat...

journal_title：Biogerontology

authors： Novikov E,Kondratyuk E,Petrovski D,Titova T,Zadubrovskaya I,Zadubrovskiy P,Moshkin M

更新日期：2015-12-01 00:00:00

abstract：:The current linear no-threshold paradigm assumes that any exposure to ionizing radiation carries some risk, thus every effort should be made to maintain the exposures as low as possible. We examined whether background radiation impacts human longevity and cancer mortality. Our data covered the entire US population of ...

journal_title：Biogerontology

authors： David E,Wolfson M,Fraifeld VE

更新日期：2021-01-22 00:00:00

abstract：:Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...

journal_title：Biogerontology

authors： Rolt A,Nair A,Cox LS

更新日期：2019-06-01 00:00:00

abstract：:During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...

journal_title：Biogerontology

authors： Holliday R

更新日期：2001-01-01 00:00:00

abstract：:Biogerontology is the study of the aging of biological systems. This review addresses the relationship between chemistry and biology during aging, proposing that chemistry is responsible for the aging of biological systems. In the continuing struggle between chemistry and biology, chemistry is always the short-term, t...

journal_title：Biogerontology

authors： Baynes JW

更新日期：2000-01-01 00:00:00

abstract：:Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer's, dialysis related amyloidosis (DRA), atherosclerosis and Parkinson's as well as physiological aging. This review attempts to summarize the data on glycation in relation...

journal_title：Biogerontology

authors： Suji G,Sivakami S

更新日期：2004-01-01 00:00:00

abstract：:Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...

journal_title：Biogerontology

authors： Unterluggauer H,Hütter E,Voglauer R,Grillari J,Vöth M,Bereiter-Hahn J,Jansen-Dürr P,Jendrach M

更新日期：2007-08-01 00:00:00

abstract：:Aging process or senescence affects the expression of a wide range of phenotypic traits throughout the life span of organisms. These traits often show modular, synergistic, and even antagonistic relationships, and are also influenced by genomic, developmental, physiological and environmental factors. The cardiovascula...

journal_title：Biogerontology

authors： Govindaraju DR,Pencina KM,Raj DS,Massaro JM,Carnes BA,D'Agostino RB

更新日期：2014-04-01 00:00:00

abstract：:The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...

journal_title：Biogerontology

authors： Kumar R,Sharma A,Padwad Y,Sharma R

更新日期：2020-06-01 00:00:00

abstract：:Melatonin synthesis is disordered in patients with Alzheimer's disease (AD). To determine the role of melatonin in the pathogenesis of AD, suitable animal models are needed. The OXYS rats are an experimental model of accelerated senescence that has also been proposed as a spontaneous rat model of AD-like pathology. In...

journal_title：Biogerontology

authors： Rudnitskaya EA,Maksimova KY,Muraleva NA,Logvinov SV,Yanshole LV,Kolosova NG,Stefanova NA

更新日期：2015-06-01 00:00:00

abstract：:There is increasing support for the notion that genetic variation for lifespan, both within and between species, is correlated with variation in the efficiency of the free radical scavenging system and the ability to withstand oxidative stress. In Drosophila, resistance to dietary paraquat, a free radical generator, i...

journal_title：Biogerontology

authors： Vermeulen CJ,Van De Zande L,Bijlsma R

更新日期：2005-12-01 00:00:00

abstract：:In mammals suprachiasmatic nucleus (SCN), acts as a light entrainable master clock and by generation of temporal oscillations regulates the peripheral organs acting as autonomous clocks resulting in overt behavioral and physiological rhythms. SCN also controls synthesis and release of melatonin (hormonal message for d...

journal_title：Biogerontology

authors： Vinod C,Jagota A

更新日期：2016-11-01 00:00:00

abstract：:Cancers are different diseases that start and evolve each in its own manner, and trigger variable responses from the organism depending upon the neoplastic process under way and upon the physiopathology of the organism. The clinical incidence of the different cancers is spread through the human life span, with regiona...

journal_title：Biogerontology

authors： Macieira-Coelho A

更新日期：2001-01-01 00:00:00

abstract：:CD4+ T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4+ T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearanc...

journal_title：Biogerontology

authors： Lorenzo EC,Bartley JM,Haynes L

更新日期：2018-12-01 00:00:00

abstract：:The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...

journal_title：Biogerontology

authors： Mocchegiani E,Basso A,Giacconi R,Piacenza F,Costarelli L,Pierpaoli S,Malavolta M

更新日期：2010-10-01 00:00:00

abstract：:Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...

journal_title：Biogerontology

authors： Russ DW,Krause J,Wills A,Arreguin R

更新日期：2012-10-01 00:00:00

abstract：:Drosophila melanogaster flies were exposed to hypergravity starting at two days of age, the range of gravity levels used being 2.58-7.38 g. No longevity change was observed for exposures of less than 14 days. The longevity of males increased if they were submitted to hypergravity for durations ranging from 14 to 24 da...

journal_title：Biogerontology

authors： Le Bourg E,Minois N,Bullens P,Baret P

更新日期：2000-01-01 00:00:00

abstract：:There are currently no reliable biomarkers of ageing. A biomarker should indicate biological age, that is, the amount of an animal's total lifespan it has lived and, therefore, the amount of time it has remaining. Some potential biomarkers cannot be validated as their measurement involves harm or death of the animal, ...

journal_title：Biogerontology

authors： Koudounas S,Green EW,Clancy D

更新日期：2012-10-01 00:00:00

abstract：:Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...

journal_title：Biogerontology

authors： Russ DW,Boyd IM,McCoy KM,McCorkle KW

更新日期：2015-12-01 00:00:00

abstract：:In this study, we have assessed the impact of vitamin E and exercise on acquisition and retention of spatial memory for a given task in aging rats, using a T-maze. Acetylcholine esterase (AChE) and cholineacetyl transferase (ChAT) activities and acetylcholine (ACh) were measured in the cerebral cortex (CC) of male Wis...

journal_title：Biogerontology

authors： Jolitha AB,Subramanyam MV,Asha Devi S

更新日期：2009-02-01 00:00:00

abstract：:Age is the principal nonmodifiable risk factor for stroke. Over the past 10 years, suitable models for stroke in aged rats have been established. At genetic and cellular level there are significant differences in behavioral, cytological and genomics responses to injury in old animals as compared with the young ones. B...

journal_title：Biogerontology

authors： Buga AM,Di Napoli M,Popa-Wagner A

更新日期：2013-12-01 00:00:00

abstract：:For a period of 6-15 days prior to death, the fecundity and virility of Drosophila melanogaster fall significantly below those of same-aged flies that are not near death. It is likely that other aspects of physiology may decline during this period. This study attempts to document changes in two physiological character...

journal_title：Biogerontology

authors： Shahrestani P,Tran X,Mueller LD

更新日期：2012-10-01 00:00:00

abstract：:Numerous reports implicate increased oxidative stress in the functional and structural changes occurring in the brain and other organs as a part of the normal aging process. Dietary restriction (DR) has long been shown to be life-prolonging intervention in several species. This study was aimed to assess the potential ...

journal_title：Biogerontology

authors： Sharma S,Singh R,Kaur M,Kaur G

更新日期：2010-04-01 00:00:00

abstract：:Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (a...

journal_title：Biogerontology

authors： Napolioni V,Lucarini N

更新日期：2010-08-01 00:00:00

abstract：:Sarcopenia, characterized by profound muscle atrophy and the loss of contractile function, contributes significantly to the development of frailty and functional impairment in older age. Although present in aging humans, rat models have failed to clearly demonstrate a similar degree of this age-associated loss of musc...

journal_title：Biogerontology

authors： Rice KM,Linderman JK,Kinnard RS,Blough ER

更新日期：2005-01-01 00:00:00

abstract：:Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...

journal_title：Biogerontology

authors： Augustyniak J,Lenart J,Zychowicz M,Stepien PP,Buzanska L

更新日期：2017-08-01 00:00:00

abstract：:Cell senescence, a state of cell cycle arrest and altered metabolism with enhanced pro-inflammatory secretion, underlies at least some aspects of organismal ageing. The sirtuin family of deacetylases has been implicated in preventing premature ageing; sirtuin overexpression or resveratrol-mediated activation of sirtui...

journal_title：Biogerontology

authors： Walters HE,Cox LS

更新日期：2019-06-01 00:00:00

abstract：:Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...

journal_title：Biogerontology

authors： Ross KS,Smith C

更新日期：2020-12-01 00:00:00

abstract：:The primary determinant of survival during aging is the energetic efficiency and metabolic stability required to counter the accumulated internal and external stresses of a lifetime. Hence, genetically stress-resistant individuals should accumulate with age; frailer, less robust, less energetically efficient and less ...

journal_title：Biogerontology

authors： Parsons PA

更新日期：2007-04-01 00:00:00