A correlation of reactive oxygen species accumulation by depletion of superoxide dismutases with age-dependent impairment in the nervous system and muscles of Drosophila adults.

abstract：:It is known that a global decrease in food ingestion (dietary restriction, DR) lowers mitochondrial ROS generation (mitROS) and oxidative stress in young immature rats. This seems to be caused by the decreased methionine ingestion of DR animals. This is interesting since isocaloric methionine restriction in the diet (...

journal_title：Biogerontology

authors： Sanchez-Roman I,Gómez A,Pérez I,Sanchez C,Suarez H,Naudí A,Jové M,Lopez-Torres M,Pamplona R,Barja G

更新日期：2012-08-01 00:00:00

abstract：:Prophylaxis with vaccines is important in geriatrics as, apart from specific protection, it reduces incidence of potentially fatal infectious complications and exacerbations of existing medical conditions. Post-vaccination protection depends on immunity and therefore markers of immune status could be used to predict e...

journal_title：Biogerontology

authors： Trzonkowski P,Myśliwska J,Pawelec G,Myśliwski A

更新日期：2009-02-01 00:00:00

abstract：:Associations have been reported between plasma Cu and Zn levels and the incidence of the most important age-related diseases. Previously proposed methods of using plasma Cu/Zn as a predictor of all-cause mortality have been derived from populations in which old and very old subjects were underrepresented. The purpose ...

journal_title：Biogerontology

authors： Malavolta M,Giacconi R,Piacenza F,Santarelli L,Cipriano C,Costarelli L,Tesei S,Pierpaoli S,Basso A,Galeazzi R,Lattanzio F,Mocchegiani E

更新日期：2010-06-01 00:00:00

abstract：:Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bat...

journal_title：Biogerontology

authors： Novikov E,Kondratyuk E,Petrovski D,Titova T,Zadubrovskaya I,Zadubrovskiy P,Moshkin M

更新日期：2015-12-01 00:00:00

abstract：:In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescen...

journal_title：Biogerontology

authors： Maciel-Barón LÁ,Morales-Rosales SL,Silva-Palacios A,Rodríguez-Barrera RH,García-Álvarez JA,Luna-López A,Pérez VI,Torres C,Königsberg M

更新日期：2018-10-01 00:00:00

abstract：:After reaching adulthood, orderly repair is probably one of the most important mechanisms throughout lifetime. Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development. Organ failure in the ageing organism...

journal_title：Biogerontology

authors： Ziesche R,Golec M,Samaha E

更新日期：2013-12-01 00:00:00

abstract：:The predominant molecular symptom of ageing is the accumulation of altered gene products. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin activity. P...

journal_title：Biogerontology

authors： Hipkiss AR

更新日期：2008-02-01 00:00:00

abstract：:There is now a significant body of research that establishes the deceleration of mortality rates in late life and their ultimate leveling off on a late-life plateau. Natural selection has been offered as one mechanism responsible for these plateaus. The force of natural selection should also exert such effects on fema...

journal_title：Biogerontology

authors： Mueller LD,Rauser CL,Rose MR

更新日期：2007-04-01 00:00:00

abstract：:The primary determinant of survival during aging is the energetic efficiency and metabolic stability required to counter the accumulated internal and external stresses of a lifetime. Hence, genetically stress-resistant individuals should accumulate with age; frailer, less robust, less energetically efficient and less ...

journal_title：Biogerontology

authors： Parsons PA

更新日期：2007-04-01 00:00:00

abstract：:Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...

journal_title：Biogerontology

authors： Hasan AU,Ohmori K,Hashimoto T,Kamitori K,Yamaguchi F,Konishi K,Noma T,Igarashi J,Yamashita T,Hirano K,Tokuda M,Minamino T,Nishiyama A,Kohno M

更新日期：2017-02-01 00:00:00

abstract：:The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by ...

journal_title：Biogerontology

authors： Pietsch K,Saul N,Menzel R,Stürzenbaum SR,Steinberg CE

更新日期：2009-10-01 00:00:00

abstract：:Cell senescence, a state of cell cycle arrest and altered metabolism with enhanced pro-inflammatory secretion, underlies at least some aspects of organismal ageing. The sirtuin family of deacetylases has been implicated in preventing premature ageing; sirtuin overexpression or resveratrol-mediated activation of sirtui...

journal_title：Biogerontology

authors： Walters HE,Cox LS

更新日期：2019-06-01 00:00:00

abstract：:It has been postulated that the presence of parasites causing high extrinsic mortality may trigger an inducible acceleration of the host aging. We tested this hypothesis using isogenic populations of Caenorhabditis elegans nematodes and different Escherichia coli strains. When exposed to pathogenic bacteria, nematodes...

journal_title：Biogerontology

authors： Baeriswyl S,Diard M,Mosser T,Leroy M,Manière X,Taddei F,Matic I

更新日期：2010-02-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells represent a well-established T cell lineage characterised in humans by TCR consisting of an invariant alpha chain encoded by Valpha24-JalphaQ genes, paired preferentially with a Vbeta11 chain. iNKT cells also share some characteristics with NK cells, such as the expression of th...

journal_title：Biogerontology

authors： Peralbo E,DelaRosa O,Gayoso I,Pita ML,Tarazona R,Solana R

更新日期：2006-10-01 00:00:00

abstract：:Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...

journal_title：Biogerontology

authors： Wensink M

更新日期：2013-02-01 00:00:00

abstract：:Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and...

journal_title：Biogerontology

authors： Bohr VA,Brosh RM Jr,von Kobbe C,Opresko P,Karmakar P

更新日期：2002-01-01 00:00:00

abstract：:eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not m...

journal_title：Biogerontology

authors： Silar P,Rossignol M,Haedens V,Derhy Z,Mazabraud A

更新日期：2000-01-01 00:00:00

abstract：:The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information regarding the mechanistic role of EGCG in the suppression of cellular senescence is limited. The present study thus assessed the effects and underlying mechanisms...

journal_title：Biogerontology

authors： Kumar R,Sharma A,Kumari A,Gulati A,Padwad Y,Sharma R

更新日期：2019-04-01 00:00:00

abstract：:Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (a...

journal_title：Biogerontology

authors： Napolioni V,Lucarini N

更新日期：2010-08-01 00:00:00

abstract：:There is a viewpoint that suppression of the proliferative capacity of cells and impairment of the regeneration of tissues and organs in aging are a consequence of specially arisen during evolution mechanisms that reduce the risk of malignant transformation and, thus, protect against cancer. We believe that the restri...

journal_title：Biogerontology

authors： Khokhlov AN

更新日期：2013-12-01 00:00:00

abstract：:Inflammation is an underlying basis for the molecular alterations that link aging and age-related pathological processes. In a previous study, we found that secretory phospholipase A(2) (sPLA(2)) induced cellular senescence in human dermal fibroblasts (HDFs). To further investigate the association of inflammation with...

journal_title：Biogerontology

authors： Yang HH,Kim C,Jung B,Kim KS,Kim JR

更新日期：2011-06-01 00:00:00

abstract：:Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...

journal_title：Biogerontology

authors： Ross KS,Smith C

更新日期：2020-12-01 00:00:00

abstract：:We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not ...

journal_title：Biogerontology

authors： Tolstun DA,Knyazer A,Tushynska TV,Dubiley TA,Bezrukov VV,Fraifeld VE,Muradian KK

更新日期：2020-04-01 00:00:00

abstract：:Accumulation of advanced glycation end products (AGEs) is accompanied by increased free radical activity which contributes to ageing and the development or worsening of degenerative diseases. Apart from other physiological factors, AGEs are also an important biomarker for premature ageing. Here we report protein modif...

journal_title：Biogerontology

authors： Hause F,Schlote D,Simm A,Hoffmann K,Santos AN

更新日期：2018-02-01 00:00:00

abstract：:The long-term effects of X-irradiation with 0.25, 0.5, 0.75 and 1 Gy of 1 h eggs on the fitness-related life history traits in adult Drosophila melanogaster fruit flies and their offspring were investigated. Following irradiation with 0.25, 0.5 and 0.75 Gy, both F0 and F1 flies have decreased adult body weight and inc...

journal_title：Biogerontology

authors： Vaiserman AM,Koshel NM,Mechova LV,Voitenko VP

更新日期：2004-01-01 00:00:00

abstract：:In the present study, we investigated whether the length of light/dark cycle could influence the pre-adult developmental time and adult life span in Drosophila melanogaster. Flies were reared to adulthood and maintained as adults under both 24-h (light/dark 12:12 h) and 48-h (light/dark 24:24 h) cycles. The flies rear...

journal_title：Biogerontology

authors： Vaiserman AM,Pisaruck AV,Timchenko AN,Voitenko VP,Koshel NM,Grigoriev PE

更新日期：2008-10-01 00:00:00

abstract：:CD4+ T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4+ T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearanc...

journal_title：Biogerontology

authors： Lorenzo EC,Bartley JM,Haynes L

更新日期：2018-12-01 00:00:00

abstract：:Evolutionary theory leads to the general expectation that dietary restriction will often result in increased survival probabilities, and thus increased lifespan. The reaction norm is a basic tool of evolutionary analysis that quantifies the relationship between environmental parameters and functional characters, inclu...

journal_title：Biogerontology

authors： Phelan JP,Rose MR

更新日期：2006-06-01 00:00:00

abstract：:Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer's, dialysis related amyloidosis (DRA), atherosclerosis and Parkinson's as well as physiological aging. This review attempts to summarize the data on glycation in relation...

journal_title：Biogerontology

authors： Suji G,Sivakami S

更新日期：2004-01-01 00:00:00

abstract：:Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...

journal_title：Biogerontology

authors： Jagota A,Mattam U

更新日期：2017-08-01 00:00:00