Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.

Abstract:

:The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by the flavonoid quercetin. In detail, quercetin was shown not to act as a simple antimicrobial agent or exclusively via radical scavenging capacities. Likewise, lifespan extension had no effect on reproduction and body length. Furthermore, neither a caloric restriction mimetic nor a sirtuin (sir-2.1) dependence was identified as a likely mode of action. However, four genes were pinpointed to be required for the quercetin derived lifespan extension, namely age-1, daf-2, unc-43 and sek-1. The latter two have, to date, not been linked to quercetin-mediated lifespan extension.

journal_name

Biogerontology

journal_title

Biogerontology

authors

Pietsch K,Saul N,Menzel R,Stürzenbaum SR,Steinberg CE

doi

10.1007/s10522-008-9199-6

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

565-78

issue

5

eissn

1389-5729

issn

1573-6768

journal_volume

10

pub_type

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