Abstract:
:The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by the flavonoid quercetin. In detail, quercetin was shown not to act as a simple antimicrobial agent or exclusively via radical scavenging capacities. Likewise, lifespan extension had no effect on reproduction and body length. Furthermore, neither a caloric restriction mimetic nor a sirtuin (sir-2.1) dependence was identified as a likely mode of action. However, four genes were pinpointed to be required for the quercetin derived lifespan extension, namely age-1, daf-2, unc-43 and sek-1. The latter two have, to date, not been linked to quercetin-mediated lifespan extension.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Pietsch K,Saul N,Menzel R,Stürzenbaum SR,Steinberg CEdoi
10.1007/s10522-008-9199-6subject
Has Abstractpub_date
2009-10-01 00:00:00pages
565-78issue
5eissn
1389-5729issn
1573-6768journal_volume
10pub_type
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