Abstract:
:eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not modify P. anserina life cycle parameters, especially longevity is not changed. These data confirm and extend those previously obtained in yeast and Drosophila.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Silar P,Rossignol M,Haedens V,Derhy Z,Mazabraud Adoi
10.1023/a:1010029723081keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
47-54issue
1eissn
1389-5729issn
1573-6768journal_volume
1pub_type
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