Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.

abstract：:The theory that accumulation of reactive oxygen species (ROS) in internal organs is a major promoter of aging has been considered negatively. However, it is still controversial whether overexpression of superoxide dismutases (SODs), which remove ROS, extends the lifespan in Drosophila adults. We examined whether ROS a...

journal_title：Biogerontology

authors： Oka S,Hirai J,Yasukawa T,Nakahara Y,Inoue YH

更新日期：2015-08-01 00:00:00

abstract：:The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information regarding the mechanistic role of EGCG in the suppression of cellular senescence is limited. The present study thus assessed the effects and underlying mechanisms...

journal_title：Biogerontology

authors： Kumar R,Sharma A,Kumari A,Gulati A,Padwad Y,Sharma R

更新日期：2019-04-01 00:00:00

abstract：:Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...

journal_title：Biogerontology

authors： Hasan AU,Ohmori K,Hashimoto T,Kamitori K,Yamaguchi F,Konishi K,Noma T,Igarashi J,Yamashita T,Hirano K,Tokuda M,Minamino T,Nishiyama A,Kohno M

更新日期：2017-02-01 00:00:00

abstract：:Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (a...

journal_title：Biogerontology

authors： Napolioni V,Lucarini N

更新日期：2010-08-01 00:00:00

abstract：:Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...

journal_title：Biogerontology

authors： Vaiserman A,Cuttler JM,Socol Y

更新日期：2021-01-09 00:00:00

abstract：:Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...

journal_title：Biogerontology

authors： Unterluggauer H,Hütter E,Voglauer R,Grillari J,Vöth M,Bereiter-Hahn J,Jansen-Dürr P,Jendrach M

更新日期：2007-08-01 00:00:00

abstract：:FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malo...

journal_title：Biogerontology

authors： Panchenko AV,Popovich IG,Trashkov AP,Egormin PA,Yurova MN,Tyndyk ML,Gubareva EA,Artyukin IN,Vasiliev AG,Khaitsev NV,Zabezhinski MA,Anisimov VN

更新日期：2016-04-01 00:00:00

abstract：:The aging theory postulates that this process may be due to the accumulation of oxidative damage in cells and molecules. The present study has investigated the effect of castration in old female rats on various parameters related to the antioxidant properties of several cellular fractions obtained from the liver, and ...

journal_title：Biogerontology

authors： Kireev RA,Tresguerres AF,Vara E,Ariznavarreta C,Tresguerres JA

更新日期：2007-10-01 00:00:00

abstract：:Aging is associated with accumulation of toxic intracellular and extracellular protein aggregates. Cells manage "aged" proteins by mobilizing their molecular chaperones or heat shock proteins that are also considered as determinants of lifespan in diverse species. In this study, we tested whether an exogenous addition...

journal_title：Biogerontology

authors： Deocaris CC,Takano S,Priyandoko D,Kaul Z,Yaguchi T,Kraft DC,Yamasaki K,Kaul SC,Wadhwa R

更新日期：2008-08-01 00:00:00

abstract：:In this study, we have assessed the impact of vitamin E and exercise on acquisition and retention of spatial memory for a given task in aging rats, using a T-maze. Acetylcholine esterase (AChE) and cholineacetyl transferase (ChAT) activities and acetylcholine (ACh) were measured in the cerebral cortex (CC) of male Wis...

journal_title：Biogerontology

authors： Jolitha AB,Subramanyam MV,Asha Devi S

更新日期：2009-02-01 00:00:00

abstract：:With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotei...

journal_title：Biogerontology

authors： Gee JR,Ding Q,Keller JN

更新日期：2006-04-01 00:00:00

abstract：:Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in a...

journal_title：Biogerontology

authors： Yang LW,Song M,Li YL,Liu YP,Liu C,Han L,Wang ZH,Zhang W,Xing YQ,Zhong M

更新日期：2019-04-01 00:00:00

abstract：:Gene expression in aging kidney and pituitary was determined by subtractive hybridization, DNA microarrays and RT-PCR. Kidneys and pituitary were removed from 10- and 30-month-old female WAG/Rij rats, which were free from chronic progressive nephrosis and had a low incidence of pituitary tumors with age. From 350 cDNA...

journal_title：Biogerontology

authors： Preisser L,Houot L,Teillet L,Kortulewski T,Morel A,Tronik-Le Roux D,Corman B

更新日期：2004-01-01 00:00:00

abstract：:After reaching adulthood, orderly repair is probably one of the most important mechanisms throughout lifetime. Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development. Organ failure in the ageing organism...

journal_title：Biogerontology

authors： Ziesche R,Golec M,Samaha E

更新日期：2013-12-01 00:00:00

abstract：:The primary determinant of survival during aging is the energetic efficiency and metabolic stability required to counter the accumulated internal and external stresses of a lifetime. Hence, genetically stress-resistant individuals should accumulate with age; frailer, less robust, less energetically efficient and less ...

journal_title：Biogerontology

authors： Parsons PA

更新日期：2007-04-01 00:00:00

abstract：:Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bat...

journal_title：Biogerontology

authors： Novikov E,Kondratyuk E,Petrovski D,Titova T,Zadubrovskaya I,Zadubrovskiy P,Moshkin M

更新日期：2015-12-01 00:00:00

abstract：:Oxidative stress caused by reactive oxygen species is proposed to cause age related muscle wasting (sarcopenia). Reversible oxidation of protein thiols by reactive oxygen species can affect protein function, so we evaluated whether muscle wasting in normal aging was associated with a pervasive increase in reversible o...

journal_title：Biogerontology

authors： Tohma H,El-Shafey AF,Croft K,Shavlakadze T,Grounds MD,Arthur PG

更新日期：2014-02-01 00:00:00

abstract：:In order to know if insulin-like signalling is involved in the control of oxidative stress in mammalian tissues in relation to aging, ad libitum-fed and caloric restricted Wistar rats were treated during 2 weeks with GH and insulin. The most consistent effect of the hormonal treatments was an increase in plasma IGF-1 ...

journal_title：Biogerontology

authors： Sanz A,Gredilla R,Pamplona R,Portero-Otín M,Vara E,Tresguerres JA,Barja G

更新日期：2005-01-01 00:00:00

abstract：:Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...

journal_title：Biogerontology

authors： Ito Y,Betsuyaku T,Moriyama C,Nasuhara Y,Nishimura M

更新日期：2009-04-01 00:00:00

abstract：:Sarcopenia, characterized by profound muscle atrophy and the loss of contractile function, contributes significantly to the development of frailty and functional impairment in older age. Although present in aging humans, rat models have failed to clearly demonstrate a similar degree of this age-associated loss of musc...

journal_title：Biogerontology

authors： Rice KM,Linderman JK,Kinnard RS,Blough ER

更新日期：2005-01-01 00:00:00

abstract：:Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. ...

journal_title：Biogerontology

authors： Ryall JG,Schertzer JD,Lynch GS

更新日期：2008-08-01 00:00:00

abstract：:Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and conditional effects of ge...

journal_title：Biogerontology

authors： Ukraintseva S,Yashin A,Arbeev K,Kulminski A,Akushevich I,Wu D,Joshi G,Land KC,Stallard E

更新日期：2016-02-01 00:00:00

abstract：:It is known that a global decrease in food ingestion (dietary restriction, DR) lowers mitochondrial ROS generation (mitROS) and oxidative stress in young immature rats. This seems to be caused by the decreased methionine ingestion of DR animals. This is interesting since isocaloric methionine restriction in the diet (...

journal_title：Biogerontology

authors： Sanchez-Roman I,Gómez A,Pérez I,Sanchez C,Suarez H,Naudí A,Jové M,Lopez-Torres M,Pamplona R,Barja G

更新日期：2012-08-01 00:00:00

abstract：:eEF1A is encoded by a unique gene in the filamentous fungus Podospora anserina. We show here that (1) this gene is essential for vegetative growth, (2) readthrough at UGA stop codon level is positively correlated with eEF1A level, (3) eEF1A level is regulated in P. anserina. (4) Increasing eEF1A gene dosage does not m...

journal_title：Biogerontology

authors： Silar P,Rossignol M,Haedens V,Derhy Z,Mazabraud A

更新日期：2000-01-01 00:00:00

abstract：:A reduced adaptation to cold is a prominent feature in aged mammals, including humans. The accelerated senescence-prone strain of mice (SAMP) has been studied as an animal model for several age-associated disorders and in the acceleration of senescence. Recent studies revealed that SAMP strains have dysfunctional hype...

journal_title：Biogerontology

authors： Yamashita Y,Chiba Y,Xia C,Hirayoshi K,Satoh M,Saitoh Y,Shimada A,Nakamura E,Hosokawa M

更新日期：2005-01-01 00:00:00

abstract：:Calorie restriction (CR) extends lifespan in a remarkable range of organisms. However, the mechanisms of CR related to the longevity effects are not fully elucidated to date. Using human fibroblast Hs68 (Hs68) cells cultured at a lower level of medium glucose (i.e., glucose restriction; GR) to mimic CR, we investigate...

journal_title：Biogerontology

authors： Yang NC,Song TY,Chang YZ,Chen MY,Hu ML

更新日期：2015-02-01 00:00:00

abstract：:There are currently no reliable biomarkers of ageing. A biomarker should indicate biological age, that is, the amount of an animal's total lifespan it has lived and, therefore, the amount of time it has remaining. Some potential biomarkers cannot be validated as their measurement involves harm or death of the animal, ...

journal_title：Biogerontology

authors： Koudounas S,Green EW,Clancy D

更新日期：2012-10-01 00:00:00

abstract：:Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in a...

journal_title：Biogerontology

authors： Yanai H,Budovsky A,Tacutu R,Fraifeld VE

更新日期：2011-12-01 00:00:00

abstract：:Adipose tissue plays a pivotal role in ageing and longevity; many studies, both human and animal, have focussed on the effects of food limitation. Here we present a new model based on striking differences between two 'normal' inbred strains of albino Wistar rats the Charles River (CR) and Harlan Olac (HO) that have ma...

journal_title：Biogerontology

authors： Kunjara S,Greenbaum AL,Rademacher TW,McLean P

更新日期：2010-08-01 00:00:00

abstract：:Parametric models for survival data help to differentiate aging from other lifespan determinants. However, such inferences suffer from small sizes of experimental animal samples and variable animals handling by different labs. We analyzed control data from a single laboratory where interventions in murine lifespan wer...

journal_title：Biogerontology

authors： Golubev A,Panchenko A,Anisimov V

更新日期：2018-10-01 00:00:00