Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice.

abstract：:The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information regarding the mechanistic role of EGCG in the suppression of cellular senescence is limited. The present study thus assessed the effects and underlying mechanisms...

journal_title：Biogerontology

authors： Kumar R,Sharma A,Kumari A,Gulati A,Padwad Y,Sharma R

更新日期：2019-04-01 00:00:00

abstract：:During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...

journal_title：Biogerontology

authors： Böttner M,Leonhardt S,Wuttke W,Wedel T,Jarry H

更新日期：2010-02-01 00:00:00

abstract：:An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...

journal_title：Biogerontology

authors： Xia J,Gravato-Nobre M,Ligoxygakis P

更新日期：2019-06-01 00:00:00

abstract：:Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...

journal_title：Biogerontology

authors： Arbeev KG,Ukraintseva SV,Arbeeva LS,Akushevich I,Kulminski AM,Yashin AI

更新日期：2011-04-01 00:00:00

abstract：:The predominant molecular symptom of ageing is the accumulation of altered gene products. Nutritional studies show that ageing in animals can be significantly influenced by dietary restriction. Genetics has revealed that ageing may be controlled by changes in intracellular NAD/NADH ratio regulating sirtuin activity. P...

journal_title：Biogerontology

authors： Hipkiss AR

更新日期：2008-02-01 00:00:00

abstract：:Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (a...

journal_title：Biogerontology

authors： Napolioni V,Lucarini N

更新日期：2010-08-01 00:00:00

abstract：:Age is the principal nonmodifiable risk factor for stroke. Over the past 10 years, suitable models for stroke in aged rats have been established. At genetic and cellular level there are significant differences in behavioral, cytological and genomics responses to injury in old animals as compared with the young ones. B...

journal_title：Biogerontology

authors： Buga AM,Di Napoli M,Popa-Wagner A

更新日期：2013-12-01 00:00:00

abstract：:High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complex...

journal_title：Biogerontology

authors： Ezcurra M

更新日期：2018-12-01 00:00:00

abstract：:Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...

journal_title：Biogerontology

authors： Ito Y,Betsuyaku T,Moriyama C,Nasuhara Y,Nishimura M

更新日期：2009-04-01 00:00:00

abstract：:Hundreds of genes and miRNAs have been identified as being involved in the determination of longevity, aging patterns and in the development of age-related diseases (ARDs). The interplay between these genes as well as the role of miRNAs in the context of protein-protein interaction networks has as yet been poorly addr...

journal_title：Biogerontology

authors： Tacutu R,Budovsky A,Fraifeld VE

更新日期：2010-08-01 00:00:00

abstract：:The mutation level (chromosome aberrations covering telomere regions), modifications of chromosome structure (level of condensed chromatin identified by the methods of electron microscopy and differential scanning microcalorimetry; level of C-banding constitutive heterochromatin; transcriptional activity of DNA-depend...

journal_title：Biogerontology

authors： Lezhava T

更新日期：2001-01-01 00:00:00

abstract：:Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...

journal_title：Biogerontology

authors： Ross KS,Smith C

更新日期：2020-12-01 00:00:00

abstract：:Evolutionary theory leads to the general expectation that dietary restriction will often result in increased survival probabilities, and thus increased lifespan. The reaction norm is a basic tool of evolutionary analysis that quantifies the relationship between environmental parameters and functional characters, inclu...

journal_title：Biogerontology

authors： Phelan JP,Rose MR

更新日期：2006-06-01 00:00:00

abstract：:Accumulating studies have argued that the mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that promotes longevity in model organisms. In the present study, we screened an off-patent drug library to identify compounds that activate UPRmt using a mitochondrial chaperone hsp-6::GFP repo...

journal_title：Biogerontology

authors： Ito A,Zhao Q,Tanaka Y,Yasui M,Katayama R,Sun S,Tanimoto Y,Nishikawa Y,Kage-Nakadai E

更新日期：2021-02-01 00:00:00

abstract：:Inflammation is an underlying basis for the molecular alterations that link aging and age-related pathological processes. In a previous study, we found that secretory phospholipase A(2) (sPLA(2)) induced cellular senescence in human dermal fibroblasts (HDFs). To further investigate the association of inflammation with...

journal_title：Biogerontology

authors： Yang HH,Kim C,Jung B,Kim KS,Kim JR

更新日期：2011-06-01 00:00:00

abstract：:We studied vascular function in quiescent aortas from senescence-accelerated resistant (SAM-R1) and prone (SAM-P8) mice. Myographical studies of thoracic aorta segments from 6-7 month-old mice showed that the contractility of SAM-P8 aortas was markedly higher than that of SAM-R1 after KCl depolarization or phenylephri...

journal_title：Biogerontology

authors： Lloréns S,de Mera RM,Pascual A,Prieto-Martín A,Mendizábal Y,de Cabo C,Nava E,Jordán J

更新日期：2007-12-01 00:00:00

abstract：:The effects of oxidative stress (OS) on the rat erythrocytes (RBCs) that were fractionated on the percoll/BSA gradient into young and old cells were studied to find out if the altered Na+/H+ and Cl⁻/ HCO3⁻ antiporters and in turn the intracellular pH (pHi) could act as one of the promoters of cell death. Old cells wer...

journal_title：Biogerontology

authors： Asha Devi S,Shiva Shankar Reddy CS,Subramanyam MV

更新日期：2009-12-01 00:00:00

abstract：:Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...

journal_title：Biogerontology

authors： Russ DW,Boyd IM,McCoy KM,McCorkle KW

更新日期：2015-12-01 00:00:00

abstract：:During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...

journal_title：Biogerontology

authors： Holliday R

更新日期：2001-01-01 00:00:00

abstract：:The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...

journal_title：Biogerontology

authors： Mocchegiani E,Basso A,Giacconi R,Piacenza F,Costarelli L,Pierpaoli S,Malavolta M

更新日期：2010-10-01 00:00:00

abstract：:Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related diseases in many organisms including humans. The present study aimed to examine the influence of long-term DR on the BDNF system at the transcriptional and translational levels in the cortex and hippocampus of middle-aged ...

journal_title：Biogerontology

authors： Smiljanic K,Pesic V,Mladenovic Djordjevic A,Pavkovic Z,Brkic M,Ruzdijic S,Kanazir S

更新日期：2015-02-01 00:00:00

abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a de novo genetic mutation that leads to the accumulation of a splicing isoform of lamin A termed progerin. Progerin expression alters the organization of the nuclear lamina and chromatin. The life expectancy of HGPS patients is severe...

journal_title：Biogerontology

authors： Brassard JA,Fekete N,Garnier A,Hoesli CA

更新日期：2016-02-01 00:00:00

abstract：:Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the...

journal_title：Biogerontology

authors： Costarelli L,Giacconi R,Malavolta M,Basso A,Piacenza F,Provinciali M,Maggio MG,Corsonello A,Lattanzio F

更新日期：2017-04-01 00:00:00

abstract：:The aging theory postulates that this process may be due to the accumulation of oxidative damage in cells and molecules. The present study has investigated the effect of castration in old female rats on various parameters related to the antioxidant properties of several cellular fractions obtained from the liver, and ...

journal_title：Biogerontology

authors： Kireev RA,Tresguerres AF,Vara E,Ariznavarreta C,Tresguerres JA

更新日期：2007-10-01 00:00:00

abstract：:Oxidative damage has been proposed as an important factor in the progression of pathological and non-pathological age-related functional declines. Here, we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidant Manganese Superoxide Dismutase (Sod2). We find that the decline of s...

journal_title：Biogerontology

authors： Piazza N,Hayes M,Martin I,Duttaroy A,Grotewiel M,Wessells R

更新日期：2009-10-01 00:00:00

abstract：:Adipose tissue plays a pivotal role in ageing and longevity; many studies, both human and animal, have focussed on the effects of food limitation. Here we present a new model based on striking differences between two 'normal' inbred strains of albino Wistar rats the Charles River (CR) and Harlan Olac (HO) that have ma...

journal_title：Biogerontology

authors： Kunjara S,Greenbaum AL,Rademacher TW,McLean P

更新日期：2010-08-01 00:00:00

abstract：:Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in a...

journal_title：Biogerontology

authors： Yang LW,Song M,Li YL,Liu YP,Liu C,Han L,Wang ZH,Zhang W,Xing YQ,Zhong M

更新日期：2019-04-01 00:00:00

abstract：:We used the Fischer 344 rat as a model for aging effects on the heart. Cardiac interfibrillar mitochondria (IFM), located between the myofibrils, exhibit a decrease in protein yield and oxidative phosphorylation through complex III and IV in elderly (24 months) compared to adult controls (6 months). In contrast, subsa...

journal_title：Biogerontology

authors： Hoppel CL,Moghaddas S,Lesnefsky EJ

更新日期：2002-01-01 00:00:00

abstract：:Death-associated protein 6 (DAXX) is a ubiquitous protein implicated in various cellular processes such as apoptosis, tumorigenesis, development and transcription. The role of DAXX is however ambiguous and many contradictory results regarding its function in apoptosis upon various cellular stresses are described in th...

journal_title：Biogerontology

authors： Lessard-Beaudoin M,Laroche M,Demers MJ,Duclos C,Denault JB,Grenier G,Riechers SP,Wanker EE,Graham RK

更新日期：2016-11-01 00:00:00

abstract：:In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to s...

journal_title：Biogerontology

authors： Zole E,Ranka R

更新日期：2018-07-01 00:00:00