Abstract：
:Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in advanced ages (but not in the young animals) may be used as a marker for biological age, i.e., to be indicative of the longevity or aging phenotype. The ability to preserve the rate of skin WH up to an old age appears to be associated with a longevity phenotype, whereas a decline in WH-with an aging phenotype. In the young, this relationship is more complex and might even be inversed. While the aging process is likely to cause wounds to heal slowly, an altered WH rate in younger animals could indicate a different cellular proliferation and/or migration capacity, which is likely to affect other major processes such as the onset and progression of cancer. As a point for future studies on WH and longevity, using only young animals might yield confusing or misleading results, and therefore including older animals in the analysis is encouraged.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Yanai H,Budovsky A,Tacutu R,Fraifeld VEdoi
10.1007/s10522-011-9343-6subject
Has Abstractpub_date
2011-12-01 00:00:00pages
591-7issue
6eissn
1389-5729issn
1573-6768journal_volume
12pub_type
杂志文章相关文献
BIOGERONTOLOGY文献大全abstract：:The theory that accumulation of reactive oxygen species (ROS) in internal organs is a major promoter of aging has been considered negatively. However, it is still controversial whether overexpression of superoxide dismutases (SODs), which remove ROS, extends the lifespan in Drosophila adults. We examined whether ROS a...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-015-9570-3
更新日期：2015-08-01 00:00:00
abstract：:In mammals suprachiasmatic nucleus (SCN), acts as a light entrainable master clock and by generation of temporal oscillations regulates the peripheral organs acting as autonomous clocks resulting in overt behavioral and physiological rhythms. SCN also controls synthesis and release of melatonin (hormonal message for d...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-016-9656-6
更新日期：2016-11-01 00:00:00
abstract：:The sample size of the data used in genetic studies is often a factor limiting the accuracy of statistical estimates. In this paper we suggest a new approach to evaluation of genetic influence on risk of development of aging-related health disorders. The approach results in substantial improvement of the accuracy of s...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-006-9072-4
更新日期：2007-06-01 00:00:00
abstract：:Obesity is associated with functional limitations in muscle performance and increased likelihood of developing a functional disability such as mobility, strength, postural and dynamic balance limitations. The consensus is that obese individuals, regardless of age, have a greater absolute maximum muscle strength compar...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-015-9626-4
更新日期：2016-06-01 00:00:00
abstract：:An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-019-09801-w
更新日期：2019-06-01 00:00:00
abstract：:After reaching adulthood, orderly repair is probably one of the most important mechanisms throughout lifetime. Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development. Organ failure in the ageing organism...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-013-9453-4
更新日期：2013-12-01 00:00:00
abstract：:The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information regarding the mechanistic role of EGCG in the suppression of cellular senescence is limited. The present study thus assessed the effects and underlying mechanisms...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-018-9785-1
更新日期：2019-04-01 00:00:00
abstract：:Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9164-4
更新日期：2009-04-01 00:00:00
abstract：:Changes in the levels of O-linked N-acetyl-glucosamine (O-GlcNAc) on nucleocytoplasmic protein have been associated with a number of age-related diseases such as Alzheimer's and diabetes; however, there is relatively little information regarding the impact of age on tissue O-GlcNAc levels. Therefore, the goal of this ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-007-9123-5
更新日期：2008-06-01 00:00:00
abstract：:During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1023/a:1010004901256
更新日期：2001-01-01 00:00:00
abstract：:FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malo...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-015-9611-y
更新日期：2016-04-01 00:00:00
abstract：:Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-019-09796-4
更新日期：2019-06-01 00:00:00
abstract：:The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-008-9199-6
更新日期：2009-10-01 00:00:00
abstract：:The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated b...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-005-7950-9
更新日期：2005-01-01 00:00:00
abstract：:Chronic oxidative stress plays a central role in the pathogenesis of many diseases, including HIV-1 associated disorders. Concomitantly with the decline of endogenous antioxidant systems, it was reported that HIV-1-related proteins increase the production of radical species in cells and tissues that are not directly i...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-014-9511-6
更新日期：2014-01-01 00:00:00
abstract：:Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1023/a:1015223917491
更新日期：2002-01-01 00:00:00
abstract：:Invariant natural killer T (iNKT) cells represent a well-established T cell lineage characterised in humans by TCR consisting of an invariant alpha chain encoded by Valpha24-JalphaQ genes, paired preferentially with a Vbeta11 chain. iNKT cells also share some characteristics with NK cells, such as the expression of th...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-006-9063-5
更新日期：2006-10-01 00:00:00
abstract：:Accumulating studies have argued that the mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that promotes longevity in model organisms. In the present study, we screened an off-patent drug library to identify compounds that activate UPRmt using a mitochondrial chaperone hsp-6::GFP repo...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-020-09907-6
更新日期：2021-02-01 00:00:00
abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a de novo genetic mutation that leads to the accumulation of a splicing isoform of lamin A termed progerin. Progerin expression alters the organization of the nuclear lamina and chromatin. The life expectancy of HGPS patients is severe...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-015-9602-z
更新日期：2016-02-01 00:00:00
abstract：:With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotei...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-005-6039-9
更新日期：2006-04-01 00:00:00
abstract：:There is now a significant body of research that establishes the deceleration of mortality rates in late life and their ultimate leveling off on a late-life plateau. Natural selection has been offered as one mechanism responsible for these plateaus. The force of natural selection should also exert such effects on fema...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-006-9042-x
更新日期：2007-04-01 00:00:00
abstract：:CD4+ T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4+ T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearanc...
journal_title：Biogerontology
pub_type： 杂志文章,评审
doi：10.1007/s10522-018-9754-8
更新日期：2018-12-01 00:00:00
abstract：:Gene expression in aging kidney and pituitary was determined by subtractive hybridization, DNA microarrays and RT-PCR. Kidneys and pituitary were removed from 10- and 30-month-old female WAG/Rij rats, which were free from chronic progressive nephrosis and had a low incidence of pituitary tumors with age. From 350 cDNA...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1023/b:bgen.0000017685.91381.40
更新日期：2004-01-01 00:00:00
abstract：:In order to know if insulin-like signalling is involved in the control of oxidative stress in mammalian tissues in relation to aging, ad libitum-fed and caloric restricted Wistar rats were treated during 2 weeks with GH and insulin. The most consistent effect of the hormonal treatments was an increase in plasma IGF-1 ...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-004-7380-0
更新日期：2005-01-01 00:00:00
abstract：:Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1023/a:1015236203379
更新日期：2002-01-01 00:00:00
abstract：:The mutation level (chromosome aberrations covering telomere regions), modifications of chromosome structure (level of condensed chromatin identified by the methods of electron microscopy and differential scanning microcalorimetry; level of C-banding constitutive heterochromatin; transcriptional activity of DNA-depend...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1023/a:1013266411263
更新日期：2001-01-01 00:00:00
abstract：:The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9274-7
更新日期：2010-12-01 00:00:00
abstract：:In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescen...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-018-9767-3
更新日期：2018-10-01 00:00:00
abstract：:Age is the principal nonmodifiable risk factor for stroke. Over the past 10 years, suitable models for stroke in aged rats have been established. At genetic and cellular level there are significant differences in behavioral, cytological and genomics responses to injury in old animals as compared with the young ones. B...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-013-9465-0
更新日期：2013-12-01 00:00:00
abstract：:Adipose tissue plays a pivotal role in ageing and longevity; many studies, both human and animal, have focussed on the effects of food limitation. Here we present a new model based on striking differences between two 'normal' inbred strains of albino Wistar rats the Charles River (CR) and Harlan Olac (HO) that have ma...
journal_title：Biogerontology
pub_type： 杂志文章
doi：10.1007/s10522-010-9271-x
更新日期：2010-08-01 00:00:00
