The impact of aging on CD4+ T cell responses to influenza infection.

abstract：:Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...

journal_title：Biogerontology

authors： Rolt A,Nair A,Cox LS

更新日期：2019-06-01 00:00:00

abstract：:Accumulating studies have argued that the mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that promotes longevity in model organisms. In the present study, we screened an off-patent drug library to identify compounds that activate UPRmt using a mitochondrial chaperone hsp-6::GFP repo...

journal_title：Biogerontology

authors： Ito A,Zhao Q,Tanaka Y,Yasui M,Katayama R,Sun S,Tanimoto Y,Nishikawa Y,Kage-Nakadai E

更新日期：2021-02-01 00:00:00

abstract：:The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...

journal_title：Biogerontology

authors： Kumar R,Sharma A,Padwad Y,Sharma R

更新日期：2020-06-01 00:00:00

abstract：:Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...

journal_title：Biogerontology

authors： Jagota A,Mattam U

更新日期：2017-08-01 00:00:00

abstract：:The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by ...

journal_title：Biogerontology

authors： Pietsch K,Saul N,Menzel R,Stürzenbaum SR,Steinberg CE

更新日期：2009-10-01 00:00:00

abstract：:Sarcopenia, defined as the age-related loss of muscle mass, subsequently has a negative effect on strength, metabolic rate and functionality leading to a reduced quality of life. With the projected increase in life expectancy, the incidence of muscle loss may rise and further drain the health care system, with greater...

journal_title：Biogerontology

authors： Candow DG

更新日期：2011-08-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells represent a well-established T cell lineage characterised in humans by TCR consisting of an invariant alpha chain encoded by Valpha24-JalphaQ genes, paired preferentially with a Vbeta11 chain. iNKT cells also share some characteristics with NK cells, such as the expression of th...

journal_title：Biogerontology

authors： Peralbo E,DelaRosa O,Gayoso I,Pita ML,Tarazona R,Solana R

更新日期：2006-10-01 00:00:00

abstract：:During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...

journal_title：Biogerontology

authors： Böttner M,Leonhardt S,Wuttke W,Wedel T,Jarry H

更新日期：2010-02-01 00:00:00

abstract：:The aging theory postulates that this process may be due to the accumulation of oxidative damage in cells and molecules. The present study has investigated the effect of castration in old female rats on various parameters related to the antioxidant properties of several cellular fractions obtained from the liver, and ...

journal_title：Biogerontology

authors： Kireev RA,Tresguerres AF,Vara E,Ariznavarreta C,Tresguerres JA

更新日期：2007-10-01 00:00:00

abstract：:Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...

journal_title：Biogerontology

authors： Sipilä S,Narici M,Kjaer M,Pöllänen E,Atkinson RA,Hansen M,Kovanen V

更新日期：2013-06-01 00:00:00

abstract：:We propose a "protein and energy" free radical model of aging that predicts patterns of survival and fertility curves for Mediterranean fruit flies. Mathematical and simulation models of individual physiological processes were constructed in terms of stochastic differential equations. The free radical theory of aging ...

journal_title：Biogerontology

authors： Butov AA,Carey JR,Volkov MA,Sehl ME,Yashin AI

更新日期：2003-01-01 00:00:00

abstract：:With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotei...

journal_title：Biogerontology

authors： Gee JR,Ding Q,Keller JN

更新日期：2006-04-01 00:00:00

abstract：:Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...

journal_title：Biogerontology

authors： Russ DW,Boyd IM,McCoy KM,McCorkle KW

更新日期：2015-12-01 00:00:00

abstract：:Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...

journal_title：Biogerontology

authors： Russ DW,Krause J,Wills A,Arreguin R

更新日期：2012-10-01 00:00:00

abstract：:Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...

journal_title：Biogerontology

authors： Arbeev KG,Ukraintseva SV,Arbeeva LS,Akushevich I,Kulminski AM,Yashin AI

更新日期：2011-04-01 00:00:00

abstract：:Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the...

journal_title：Biogerontology

authors： Chondrogianni N,Fragoulis EG,Gonos ES

更新日期：2002-01-01 00:00:00

abstract：:Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...

journal_title：Biogerontology

authors： Hasan AU,Ohmori K,Hashimoto T,Kamitori K,Yamaguchi F,Konishi K,Noma T,Igarashi J,Yamashita T,Hirano K,Tokuda M,Minamino T,Nishiyama A,Kohno M

更新日期：2017-02-01 00:00:00

abstract：:Melatonin synthesis is disordered in patients with Alzheimer's disease (AD). To determine the role of melatonin in the pathogenesis of AD, suitable animal models are needed. The OXYS rats are an experimental model of accelerated senescence that has also been proposed as a spontaneous rat model of AD-like pathology. In...

journal_title：Biogerontology

authors： Rudnitskaya EA,Maksimova KY,Muraleva NA,Logvinov SV,Yanshole LV,Kolosova NG,Stefanova NA

更新日期：2015-06-01 00:00:00

abstract：:Changes in the levels of O-linked N-acetyl-glucosamine (O-GlcNAc) on nucleocytoplasmic protein have been associated with a number of age-related diseases such as Alzheimer's and diabetes; however, there is relatively little information regarding the impact of age on tissue O-GlcNAc levels. Therefore, the goal of this ...

journal_title：Biogerontology

authors： Fülöp N,Feng W,Xing D,He K,Nőt LG,Brocks CA,Marchase RB,Miller AP,Chatham JC

更新日期：2008-06-01 00:00:00

abstract：:Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...

journal_title：Biogerontology

authors： Witham MD

更新日期：2019-04-01 00:00:00

abstract：:Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and...

journal_title：Biogerontology

authors： Bohr VA,Brosh RM Jr,von Kobbe C,Opresko P,Karmakar P

更新日期：2002-01-01 00:00:00

abstract：:We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not ...

journal_title：Biogerontology

authors： Tolstun DA,Knyazer A,Tushynska TV,Dubiley TA,Bezrukov VV,Fraifeld VE,Muradian KK

更新日期：2020-04-01 00:00:00

abstract：:Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...

journal_title：Biogerontology

authors： Unterluggauer H,Hütter E,Voglauer R,Grillari J,Vöth M,Bereiter-Hahn J,Jansen-Dürr P,Jendrach M

更新日期：2007-08-01 00:00:00

abstract：:It has been postulated that the presence of parasites causing high extrinsic mortality may trigger an inducible acceleration of the host aging. We tested this hypothesis using isogenic populations of Caenorhabditis elegans nematodes and different Escherichia coli strains. When exposed to pathogenic bacteria, nematodes...

journal_title：Biogerontology

authors： Baeriswyl S,Diard M,Mosser T,Leroy M,Manière X,Taddei F,Matic I

更新日期：2010-02-01 00:00:00

abstract：:The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...

journal_title：Biogerontology

authors： Jylhävä J,Eklund C,Jylhä M,Hervonen A,Hurme M

更新日期：2010-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) are formed by all aerobic organisms, and are involved in the numerous physiological and pathophysiological processes. Opioid peptides belong to a class of bioactive compounds of great interest because of their opiate-like activity. We determined the influence of methionine-enkephalin (MEN...

journal_title：Biogerontology

authors： Sobocanec S,Kusić B,Sverko V,Balog T,Marotti T

更新日期：2006-02-01 00:00:00

abstract：:Behavioral symptoms of sickness, such as fever and motor activity are a coordinated set of changes that develop during infection. The aim of study was to compare the sickness behaviour (SB) in healthy old and young rats treated with pyrogenic dose of endotoxin and to check their glutathione level. Before experimentati...

journal_title：Biogerontology

authors： Wrotek S,Jędrzejewski T,Nowakowska A,Kozak W

更新日期：2016-08-01 00:00:00

abstract：:Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (a...

journal_title：Biogerontology

authors： Napolioni V,Lucarini N

更新日期：2010-08-01 00:00:00

abstract：:We studied vascular function in quiescent aortas from senescence-accelerated resistant (SAM-R1) and prone (SAM-P8) mice. Myographical studies of thoracic aorta segments from 6-7 month-old mice showed that the contractility of SAM-P8 aortas was markedly higher than that of SAM-R1 after KCl depolarization or phenylephri...

journal_title：Biogerontology

authors： Lloréns S,de Mera RM,Pascual A,Prieto-Martín A,Mendizábal Y,de Cabo C,Nava E,Jordán J

更新日期：2007-12-01 00:00:00

abstract：:It is known that a global decrease in food ingestion (dietary restriction, DR) lowers mitochondrial ROS generation (mitROS) and oxidative stress in young immature rats. This seems to be caused by the decreased methionine ingestion of DR animals. This is interesting since isocaloric methionine restriction in the diet (...

journal_title：Biogerontology

authors： Sanchez-Roman I,Gómez A,Pérez I,Sanchez C,Suarez H,Naudí A,Jové M,Lopez-Torres M,Pamplona R,Barja G

更新日期：2012-08-01 00:00:00