Abstract:
:There is a viewpoint that suppression of the proliferative capacity of cells and impairment of the regeneration of tissues and organs in aging are a consequence of specially arisen during evolution mechanisms that reduce the risk of malignant transformation and, thus, protect against cancer. We believe that the restriction of cell proliferation in an aging multicellular organism is not a consequence of implementing a special program of aging. Apparently, such a program does not exist at all and aging is only a "byproduct" of the program of development, implementation of which in higher organisms suggests the need for the emergence of cell populations with very low or even zero proliferative activity, which determines the limited capacity of relevant organs and tissues to regenerate. At the same time, it is the presence of highly differentiated cell populations, barely able or completely unable to reproduce (neurons, cardiomyocytes, hepatocytes), that ensures the normal functioning of the higher animals and humans. Apparently, the impairment of regulatory processes, realized at the neurohumoral level, still plays the main role in the mechanisms of aging of multicellular organisms, not just the accumulation of macromolecular defects in individual cells. It seems that the quality of the cells themselves does not worsen with age as much as reliability of the organism control over cells, organs and tissues, which leads to an increase in the probability of death.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Khokhlov ANdoi
10.1007/s10522-013-9468-xsubject
Has Abstractpub_date
2013-12-01 00:00:00pages
703-8issue
6eissn
1389-5729issn
1573-6768journal_volume
14pub_type
杂志文章,评审相关文献
BIOGERONTOLOGY文献大全abstract::Human aging processes are regulated by many divergent pathways and on many levels. Thus, to understand such a complex system and define conserved mechanisms of aging, the use of cell culture-based models is a widespread practice. An often stated advantage of in vitro aging of primary cells is the high reproducibility ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9082-x
更新日期:2007-08-01 00:00:00
abstract::The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09861-3
更新日期:2020-06-01 00:00:00
abstract::Longevity is mainly conditioned by genetic, epigenetic and environmental factors. Different genetic modifications seem to be positively associated to longevity, including SNPs in SIRT1, APOE, FOXO3A, ACE, ATM, NOS1 and NOS2 gene. Epigenetic changes as DNA hyper- and hypo-methylation influence significantly human longe...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-019-09824-3
更新日期:2019-10-01 00:00:00
abstract::Parametric models for survival data help to differentiate aging from other lifespan determinants. However, such inferences suffer from small sizes of experimental animal samples and variable animals handling by different labs. We analyzed control data from a single laboratory where interventions in murine lifespan wer...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9759-3
更新日期:2018-10-01 00:00:00
abstract::Two sibling Drosophila species dramatically divergent in longevity, Drosophila buzzatii and D. koepferae, were examined for possible effects of both developmental culture medium and dietary composition (DC) on longevity. Longevity was greatly increased in the longer lived D. buzzatii when flies were reared and fed on ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9441-8
更新日期:2013-08-01 00:00:00
abstract::There is now a significant body of research that establishes the deceleration of mortality rates in late life and their ultimate leveling off on a late-life plateau. Natural selection has been offered as one mechanism responsible for these plateaus. The force of natural selection should also exert such effects on fema...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-006-9042-x
更新日期:2007-04-01 00:00:00
abstract::The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09867-x
更新日期:2020-06-01 00:00:00
abstract::Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9399-y
更新日期:2012-10-01 00:00:00
abstract::Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09796-4
更新日期:2019-06-01 00:00:00
abstract::Accumulation of advanced glycation end products (AGEs) is accompanied by increased free radical activity which contributes to ageing and the development or worsening of degenerative diseases. Apart from other physiological factors, AGEs are also an important biomarker for premature ageing. Here we report protein modif...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-017-9733-5
更新日期:2018-02-01 00:00:00
abstract::The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated b...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-7950-9
更新日期:2005-01-01 00:00:00
abstract::Death-associated protein 6 (DAXX) is a ubiquitous protein implicated in various cellular processes such as apoptosis, tumorigenesis, development and transcription. The role of DAXX is however ambiguous and many contradictory results regarding its function in apoptosis upon various cellular stresses are described in th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9651-y
更新日期:2016-11-01 00:00:00
abstract::Histone post-translational modifications (PTMs) are involved in diverse biological processes and methylation was regarded as a long-term epigenetic mark. Though aging represented one of the major risk factors for neurodegenerative diseases, no systematic investigations had correlated the patterns of histone PTMs in th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9231-5
更新日期:2010-02-01 00:00:00
abstract::Associations have been reported between plasma Cu and Zn levels and the incidence of the most important age-related diseases. Previously proposed methods of using plasma Cu/Zn as a predictor of all-cause mortality have been derived from populations in which old and very old subjects were underrepresented. The purpose ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9251-1
更新日期:2010-06-01 00:00:00
abstract::With normal aging, the brain undergoes several alterations including reduced neuronal functioning and alterations in glia homeostasis. An increase in inflammatory signaling has also been reported in some studies of the aging brain, with inflammation potentially mediating age-related changes in the brain. Apolipoprotei...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-6039-9
更新日期:2006-04-01 00:00:00
abstract::Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9661-9
更新日期:2017-02-01 00:00:00
abstract::Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-017-9718-4
更新日期:2017-08-01 00:00:00
abstract::The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9276-5
更新日期:2010-10-01 00:00:00
abstract::Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-09793-z
更新日期:2019-04-01 00:00:00
abstract::Adipose tissue plays a pivotal role in ageing and longevity; many studies, both human and animal, have focussed on the effects of food limitation. Here we present a new model based on striking differences between two 'normal' inbred strains of albino Wistar rats the Charles River (CR) and Harlan Olac (HO) that have ma...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9271-x
更新日期:2010-08-01 00:00:00
abstract::It has been postulated that the presence of parasites causing high extrinsic mortality may trigger an inducible acceleration of the host aging. We tested this hypothesis using isogenic populations of Caenorhabditis elegans nematodes and different Escherichia coli strains. When exposed to pathogenic bacteria, nematodes...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9228-0
更新日期:2010-02-01 00:00:00
abstract::After reaching adulthood, orderly repair is probably one of the most important mechanisms throughout lifetime. Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development. Organ failure in the ageing organism...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9453-4
更新日期:2013-12-01 00:00:00
abstract::Evolutionary theory leads to the general expectation that dietary restriction will often result in increased survival probabilities, and thus increased lifespan. The reaction norm is a basic tool of evolutionary analysis that quantifies the relationship between environmental parameters and functional characters, inclu...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-006-9005-2
更新日期:2006-06-01 00:00:00
abstract::Melatonin synthesis is disordered in patients with Alzheimer's disease (AD). To determine the role of melatonin in the pathogenesis of AD, suitable animal models are needed. The OXYS rats are an experimental model of accelerated senescence that has also been proposed as a spontaneous rat model of AD-like pathology. In...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-014-9547-7
更新日期:2015-06-01 00:00:00
abstract::Menopause marks the end of the reproductive life span of women and is characterized by a dramatic drop of circulating estrogen. Hormone replacement therapy (HRT) has been successfully used to treat the symptoms of menopause because estrogen has strong suppressive effects on climacteric complaints. As the hypothalamo-p...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-2623-2
更新日期:2005-01-01 00:00:00
abstract::Regular exercise is an important part of a healthy lifestyle, as it helps maintain a healthy weight and reduces the risk of chronic diseases. We explored the effects of lifelong exercise and aging on rat metabolism through a metabolomics approach. Thirty-six rats were divided into four equal groups: exercise during th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09871-1
更新日期:2020-10-01 00:00:00
abstract::Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9164-4
更新日期:2009-04-01 00:00:00
abstract::Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven by highly conserved cell intrinsic processes, and a set of unifying hallmarks of ageing has been defined. Here, we survey reports of age-l...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-018-9750-z
更新日期:2018-12-01 00:00:00
abstract::Oxidative stress caused by reactive oxygen species is proposed to cause age related muscle wasting (sarcopenia). Reversible oxidation of protein thiols by reactive oxygen species can affect protein function, so we evaluated whether muscle wasting in normal aging was associated with a pervasive increase in reversible o...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9483-y
更新日期:2014-02-01 00:00:00
abstract::High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complex...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9752-x
更新日期:2018-12-01 00:00:00