Abstract:
:Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvested medial gastrocnemius muscles from F344/BN rats that were adult (8 months; n = 8), aging (24 months; n = 8) and that aged with wheel access for 16 months (24 months; n = 4). SR calcium handling assays and immunoblotting (Caspase 12, dysferlin and LC3) were performed on crude homogenates and SR-enriched microsomal fractions. Aging was associated with increased Caspase 12 and SR dysferlin, as well as a reduced LC3II/I ratio and impaired calcium release. Despite further increases in Caspase 12, voluntary wheel running partially restored SR calcium release and dysferlin toward younger levels. Of note, the LC3II/I was also partially restored in the voluntary wheel running group, suggesting increased autophagy. These results suggest that impaired SR function with aging is associated with age-related increases in SR stress, possibly related to reduced autophagy. Long-term volitional exercise improved SR function and markers of autophagy, despite increased Caspase 12, suggesting that running contributed a beneficial stress that differed from the "distress" of sedentary aging.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Russ DW,Krause J,Wills A,Arreguin Rdoi
10.1007/s10522-012-9399-ysubject
Has Abstractpub_date
2012-10-01 00:00:00pages
547-55issue
5eissn
1389-5729issn
1573-6768journal_volume
13pub_type
杂志文章相关文献
BIOGERONTOLOGY文献大全abstract::Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related diseases in many organisms including humans. The present study aimed to examine the influence of long-term DR on the BDNF system at the transcriptional and translational levels in the cortex and hippocampus of middle-aged ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-014-9537-9
更新日期:2015-02-01 00:00:00
abstract::Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-09793-z
更新日期:2019-04-01 00:00:00
abstract::Ageing can have profound effects on the post-mitotic organ of behaviour, the brain. As yet the precise causes of these deleterious effects are unknown. However, clear insights into the putative mechanisms and consequences of ageing in the CNS have been achieved through the use of invertebrate models. It is now clear t...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1023/a:1011597420036
更新日期:2001-01-01 00:00:00
abstract::Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9598-4
更新日期:2015-12-01 00:00:00
abstract::Aging is associated with accumulation of toxic intracellular and extracellular protein aggregates. Cells manage "aged" proteins by mobilizing their molecular chaperones or heat shock proteins that are also considered as determinants of lifespan in diverse species. In this study, we tested whether an exogenous addition...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9136-8
更新日期:2008-08-01 00:00:00
abstract::The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9274-7
更新日期:2010-12-01 00:00:00
abstract::Behavioral symptoms of sickness, such as fever and motor activity are a coordinated set of changes that develop during infection. The aim of study was to compare the sickness behaviour (SB) in healthy old and young rats treated with pyrogenic dose of endotoxin and to check their glutathione level. Before experimentati...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9636-x
更新日期:2016-08-01 00:00:00
abstract::In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade. Identifying and...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-014-9527-y
更新日期:2015-04-01 00:00:00
abstract::The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09861-3
更新日期:2020-06-01 00:00:00
abstract::During the evolution of hominids, the population could be sustained even with an expectation of life at birth of less than 20 years. Under these circumstances very few individuals reached old age. In these hunter-gatherer communities, altruistic behaviour was encouraged because it increased the likelihood of survival,...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1023/a:1010004901256
更新日期:2001-01-01 00:00:00
abstract::An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-019-09801-w
更新日期:2019-06-01 00:00:00
abstract::The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09867-x
更新日期:2020-06-01 00:00:00
abstract::With advancing age, memory declines through different mechanisms including dysregulation of expression of synaptic plasticity genes in hippocampus. Increasing evidences suggest that these synaptic plasticity genes are regulated through epigenetic modifications. Recently we have reported that the neuronal immediate ear...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09850-1
更新日期:2020-04-01 00:00:00
abstract::Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9675-3
更新日期:2017-04-01 00:00:00
abstract::After reaching adulthood, orderly repair is probably one of the most important mechanisms throughout lifetime. Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development. Organ failure in the ageing organism...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9453-4
更新日期:2013-12-01 00:00:00
abstract::High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complex...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9752-x
更新日期:2018-12-01 00:00:00
abstract::The current linear no-threshold paradigm assumes that any exposure to ionizing radiation carries some risk, thus every effort should be made to maintain the exposures as low as possible. We examined whether background radiation impacts human longevity and cancer mortality. Our data covered the entire US population of ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09909-4
更新日期:2021-01-22 00:00:00
abstract::Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9787-z
更新日期:2019-04-01 00:00:00
abstract::Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09891-x
更新日期:2020-12-01 00:00:00
abstract::The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9199-6
更新日期:2009-10-01 00:00:00
abstract::Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-020-09908-5
更新日期:2021-01-09 00:00:00
abstract::Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-011-9343-6
更新日期:2011-12-01 00:00:00
abstract::In order to know if insulin-like signalling is involved in the control of oxidative stress in mammalian tissues in relation to aging, ad libitum-fed and caloric restricted Wistar rats were treated during 2 weeks with GH and insulin. The most consistent effect of the hormonal treatments was an increase in plasma IGF-1 ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-004-7380-0
更新日期:2005-01-01 00:00:00
abstract::Obesity is associated with functional limitations in muscle performance and increased likelihood of developing a functional disability such as mobility, strength, postural and dynamic balance limitations. The consensus is that obese individuals, regardless of age, have a greater absolute maximum muscle strength compar...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-015-9626-4
更新日期:2016-06-01 00:00:00
abstract::Longevity is mainly conditioned by genetic, epigenetic and environmental factors. Different genetic modifications seem to be positively associated to longevity, including SNPs in SIRT1, APOE, FOXO3A, ACE, ATM, NOS1 and NOS2 gene. Epigenetic changes as DNA hyper- and hypo-methylation influence significantly human longe...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-019-09824-3
更新日期:2019-10-01 00:00:00
abstract::Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-008-9131-0
更新日期:2008-08-01 00:00:00
abstract::Aging is a natural process determined by both genetic and environmental factors. Aging is accompanied by the imbalance of the function of several cellular homeostatic mechanisms, which results, among others, in the accumulation of abnormal (i.e. oxidized, cross-linked, unfolded) proteins. It has been proposed that the...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/a:1015236203379
更新日期:2002-01-01 00:00:00
abstract::There are currently no reliable biomarkers of ageing. A biomarker should indicate biological age, that is, the amount of an animal's total lifespan it has lived and, therefore, the amount of time it has remaining. Some potential biomarkers cannot be validated as their measurement involves harm or death of the animal, ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9393-4
更新日期:2012-10-01 00:00:00
abstract::We studied vascular function in quiescent aortas from senescence-accelerated resistant (SAM-R1) and prone (SAM-P8) mice. Myographical studies of thoracic aorta segments from 6-7 month-old mice showed that the contractility of SAM-P8 aortas was markedly higher than that of SAM-R1 after KCl depolarization or phenylephri...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-007-9108-4
更新日期:2007-12-01 00:00:00
abstract::Sarcopenia, characterized by profound muscle atrophy and the loss of contractile function, contributes significantly to the development of frailty and functional impairment in older age. Although present in aging humans, rat models have failed to clearly demonstrate a similar degree of this age-associated loss of musc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-4808-0
更新日期:2005-01-01 00:00:00