Abstract:
:Mugwort pollen allergy is frequent in parts of Europe. As mugwort pollen contains only one major allergen, Art v 1, which harbors only one T cell epitope, we employed mugwort pollen allergy as a model to study allergen-specific T cell responses. However, after 2004, we noticed a drastic decrease in the T cell responses to Art v 1 and eventually it became almost impossible to detect allergen-specific responses at the T cell level in mugwort-allergic individuals. To explain this observation, we retrospectively investigated the local exposure to mugwort pollen and its possible correlation to the frequency and reactivity of allergen-specific T cells. The total annual pollen indices dramatically dropped after 2004 and never reached previous levels again. Local sensitization to mugwort pollen and serum IgE antibodies specific for Art v 1 remained unchanged until 2015. Our mugwort pollen model shows that specific IgE-levels are maintained for extremely long time periods in spite of a long-term reduction of natural allergen exposure to levels that are too low to boost specific T cells.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Van Hemelen D,Hemmer W,Kmenta M,Berger UB,Kinaciyan T,Bohle B,Jahn-Schmid Bdoi
10.1016/j.imbio.2019.07.003subject
Has Abstractpub_date
2019-09-01 00:00:00pages
645-648issue
5eissn
0171-2985issn
1878-3279pii
S0171-2985(19)30104-4journal_volume
224pub_type
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