Abstract:
:The goal of our work was to titer the IgG, IgM and IgA in Pentaglobin® (a preparation enriched in IgM), targeting specific surface antigens of Gram-positive and Gram-negative bacteria as well as a C. albicans strain. Lipopolysaccharides from Gram-negative bacteria, peptidoglycan and lipoteichoic acid from the other microorganisms were extracted and used in several ELISA assays in order to determine the titration of immunoglobulins in Pentaglobin® directed towards the aforementioned surface antigens. Our results showed an overall immunoglobulin titer of at least 103 in Pentaglobin® with some exceptions for the IgA titers and for some immunoglobulin titers against E. faecalis, K. pneumoniae and P. aeruginosa. According to these results, Pentaglobin® can be considered as a potential adjuvant for antimicrobial therapy.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Stracquadanio S,Lo Verde F,Cialfi A,Zega A,Stefani S,Cafiso Vdoi
10.1016/j.imbio.2019.12.006subject
Has Abstractpub_date
2020-03-01 00:00:00pages
151897issue
2eissn
0171-2985issn
1878-3279pii
S0171-2985(19)30373-0journal_volume
225pub_type
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