当前位置： SCI文献检索 > IMMUNOBIOLOGY期刊下所有文献 > Diagnostic and prognostic roles of peripheral blood Toll-like receptor-4 and stanniocalcin-1 genes expression in acute lung injury.

Diagnostic and prognostic roles of peripheral blood Toll-like receptor-4 and stanniocalcin-1 genes expression in acute lung injury.

Abstract：

:Acute lung injury (ALI) is an acute inflammatory disorder. Toll-like receptor-4 (TLR-4) and Stanniocalcin -1 (STC-1) had roles in lung endothelial protection. This study aims to assess TLR-4 and SCT-1 genes expressions in peripheral blood of ALI patients. Total RNA was extracted from peripheral blood of 48 subjects (20 healthy controls, 28 ALI patients) and expressions of genes were assessed by real-Time qRT-PCR. The expression levels of TLR-4 and SCT-1 genes were significantly lower in ALI patients compared to controls (P < 0.0001). After 10 days, the expression levels of TLR-4 and SCT-1 were increased compared to their baseline levels (p = 0.012 and 0.024, respectively). SCT-1 has 92.9% sensitivity and 100% specificity in ALI detection. SCT-1 gene expression was negatively correlated with severity score (r= -0.54, p = 0.003). The mortality pattern was higher in ALI patients with lower TLR-4 gene expression (p = 0.014). In conclusion, the peripheral blood expressions of TLR-4 and STC-1 genes were decreased in ALI patients. Both genes expressions were increased with patients' recovery. SCT-1 had higher sensitivity and specificity in ALI diagnosis. The peripheral blood expressions of SCT-1 and TLR-4 genes seem to be diagnostic and prognostic markers in ALI.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Esawy MM,Shabana MA,Baioumy SA,Ismail NA

doi

10.1016/j.imbio.2019.09.003

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

734-738

issue

6

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(19)30147-0

journal_volume

224

pub_type

杂志文章

相关文献

IMMUNOBIOLOGY文献大全
  • Distribution of MEL-14+ cells in various lymphoid tissues.

    abstract：:The distribution of MEL-14+ lymphocytes was investigated by both fluorocytometric analysis and complement-dependent-cellular-cytotoxicity (CDCC) tests in which rabbit anti-rat Ig was added with complement at a secondary step. When CDCC was employed to detect MEL-14+ cells, almost half of the thymocytes were found to b...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80200-7

    authors： Iwabuchi K,Ohgama J,Ogasawara K,Iwabuchi C,Negishi I,Good RA,Onoé K

    更新日期：1991-03-01 00:00:00

  • Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis.

    abstract：:Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins. These enzymes are best known for their roles in modulating the activity of kinins, complement anaphylatoxins and coa...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2013.08.007

    authors： Hu X,Wetsel RA,Ramos TN,Mueller-Ortiz SL,Schoeb TR,Barnum SR

    更新日期：2014-02-01 00:00:00

  • NLRC5 polymorphism is associated with susceptibility to chronic periodontitis.

    abstract：:Periodontitis is a chronic oral pathology caused by impaired immune response against oral bacteria resulting in tissue inflammation and damage. Among the members of innate immune response, the first line of defence against pathogens, inflammasomes are macro-molecular protein complexes that can be activated by differen...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2017.01.001

    authors： Zupin L,Navarra CO,Robino A,Bevilacqua L,Di Lenarda R,Gasparini P,Crovella S

    更新日期：2017-05-01 00:00:00

  • Enhancement of antigen-specific activation of CD8+ memory cytotoxic T cells by B cell-derived factors.

    abstract：:Purified CD8+ T cells from influenza A/WSN-immune BALB/c (H-2d) mice respond with the generation of secondary A/WSN-specific Tc cells in vitro when stimulated with a synthetic peptide (NPP) with a sequence derived from influenza A virus nucleoprotein with high affinity for Kd class I MHC molecules. The process of the ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(11)80394-3

    authors： Kos FJ,Müllbacher A

    更新日期：1992-11-01 00:00:00

  • The immunologic properties of undifferentiated and osteogenic differentiated mouse mesenchymal stem cells and its potential application in bone regeneration.

    abstract：:The concept of using mesenchymal stem cells (MSCs) in bone repair has progressively evolved, and the goal of cell-mediated therapy is to prolong the natural physiological abilities of healing, or substitute them, when these are lacking, failing, or progressing too slowly. The future application of MSCs in human therap...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2008.07.030

    authors： Zhang X,Tang T,Shi Q,Fernandes JC,Dai K

    更新日期：2009-01-01 00:00:00

  • Cyclophosphamide-induced immunological tolerance: an overview.

    abstract：:A cyclophosphamide (CP)-induced tolerance system in mice that primarily consists of donor cell injection followed by CP-treatment was found useful for inducing a long-lasting allo- or xeno-tolerance to various solid organs. In the cells-followed-by-CP system, the sequential mechanisms of tolerance were clarified using...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/S0171-2985(96)80033-7

    authors： Mayumi H,Umesue M,Nomoto K

    更新日期：1996-07-01 00:00:00

  • DAP10 contributes to CD8(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection.

    abstract：:The activating C-type lectin-like receptor NKG2D, which is expressed by mouse NK cells and activated CD8 T cells, was previously demonstrated to be involved in tumor rejection and as a defense mechanism against viral and bacterial infections. Because CD8 T cells are important for protective immune responses during chr...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2010.09.010

    authors： Hessmann M,Rausch A,Rückerl D,Adams PS,Simon M,Gilfillan S,Colonna M,Ehlers S,Hölscher C

    更新日期：2011-05-01 00:00:00

  • A "spontaneous" cold-reactive IgM antibody with anti HLA-B8 specificity in a patient with multiple sclerosis.

    abstract：:A case of a 35-year-old female with multiple sclerosis is reported who developed without apparent prior sensitization a lymphocytotoxic antibody with anti-HLA-B8 specificity. The antibody persisted for several years with the same titer. The cytotoxic activity of the patient's serum was contained within the IgM fractio...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(82)80002-8

    authors： Lenhard V,Diehm H,Römer W,Rauterberg EW,Kownatzki E,Roelcke D

    更新日期：1982-02-01 00:00:00

  • A mouse ear reaction for assessment of human lymphocyte immunocompetence.

    abstract：:A mouse ear reaction for testing cell mediated immunity of human lymphocytes using the local graft-versus-host reaction assay is described. Five million human mononuclears were locally injected into the ears of immune suppressed NZW mice. The reaction mounted was quantitated by determining the 125I-Iodo-Deoxyuridine (...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(85)80050-4

    authors： Mukamel E,Umiel T,Shohat B,Pecht M,Servadio C,Trainin N

    更新日期：1985-02-01 00:00:00

  • Induction of tolerance to non-H-2 alloantigens is not restricted by the MHC molecules expressed on the donor cells in cyclophosphamide-induced tolerance.

    abstract：:A long-lasting skin tolerance to non-H-2 alloantigens has been reported to be readily induced, when the recipient mice were primed intravenously (i.v.) with 5 x 10(7) spleen cells (SC) plus 1.5 x 10(7) bone marrow cells (BMC) from the H-2 identical strains of mice, and treated intraperitoneally (i.p.) with 200 mg/kg C...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80511-5

    authors： Tomita Y,Nomoto K

    更新日期：1990-11-01 00:00:00

  • The dopamine D3 receptor regulates the effects of methamphetamine on LPS-induced cytokine production in murine mast cells.

    abstract：:Previous studies have demonstrated that methamphetamine (METH) alter inflammatory and anti-inflammatory cytokine production in the periphery. However, the effect of METH on lipopolysaccharide (LPS)-induced immune responses and its underlying mechanism of action remains unclear. The dopamine D3 receptor (D3R) plays an ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.12.021

    authors： Xue L,Li X,Ren HX,Wu F,Li M,Wang B,Chen FY,Cheng WY,Li JP,Chen YJ,Chen T

    更新日期：2015-06-01 00:00:00

  • Up regulation of nitric oxide synthase-nitric oxide system in the testis of rats undergoing autoimmune orchitis.

    abstract：BACKGROUND:Male reproductive tract infection and inflammation are important aetiological factors of infertility. Experimental Autoimmune Orchitis (EAO) is a model of chronic inflammation useful to study mechanisms of inflammatory reactions leading to testicular impairment. EAO is characterised by interstitial cell infi...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2012.04.007

    authors： Jarazo-Dietrich S,Jacobo P,Pérez CV,Guazzone VA,Lustig L,Theas MS

    更新日期：2012-08-01 00:00:00

  • Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells.

    abstract：:In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating e...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2009.10.003

    authors： Boldizsar F,Talaber G,Szabo M,Bartis D,Palinkas L,Nemeth P,Berki T

    更新日期：2010-07-01 00:00:00

  • Activation of human macrophage sodium channels regulates RNA processing to increase expression of the DNA repair protein PPP1R10.

    abstract：:Prior work demonstrated that a splice variant of SCN5A, a voltage-gated sodium channel gene, acts as a cytoplasmic sensor for viral dsRNA in human macrophages. Expression of this channel also polarizes macrophages to an anti-inflammatory phenotype in vitro and in vivo. Here we utilized global expression analysis of sp...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2018.10.005

    authors： White CR,Dungan M,Carrithers MD

    更新日期：2019-01-01 00:00:00

  • Anti-complement factor I antibody associated atypical hemolytic uremic syndrome - A new insight for future perspective!

    abstract：:Atypical hemolytic uremic syndrome (aHUS) is caused mainly by complement dysregulation. Although various defects in the complement system explaining pathophysiology have been described in recent years, the etiology still remains unclear in about thirty percent of cases. In exploring other causes, similar to anti- comp...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2020.152000

    authors： Govindarajan S,Rawat A,Ramachandran R,Hans R,Dawman L,Tiewsoh K

    更新日期：2020-09-01 00:00:00

  • Suppressor activity in the supernatant of T cell clones derived from chimeric mouse spleen cells.

    abstract：:The supernatant from cultures of T cell clones derived from (BALB/c----C3H/He) chimeras suppresses BALB/c anti-C3H/He or BALB/c anti-C57BL/6 MLRs. When we studied the alloantigen specificity of the suppressor activity in culture supernatant, we observed three types of the suppressor activity (i.e., the suppressor acti...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(88)80095-0

    authors： Imamura M,Fujimoto H,Fukuhara T,Kobayashi M,Hashino S,Kasai M,Sakurada K,Miyazaki T

    更新日期：1988-04-01 00:00:00

  • Molecular principles of Oct2-mediated gene activation in B cells.

    abstract：:The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism. We could demo...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/S0171-2985(11)80540-1

    authors： Wirth T,Pfisterer P,Annweiler A,Zwilling S,König H

    更新日期：1995-07-01 00:00:00

  • CD8+ T cell populations in common variable immunodeficiency.

    abstract：:In a subgroup of CVID T cell abnormalities have been reported. Peripheral blood T lymphocytes from patients with common variable immunodeficiency (CVID) and blood donors were examined for expression of CD8alpha, CD8beta and CD28. In CVID, three CD8+ T cells could be defined: CD8beta(high)CD28+ (expressing CD8beta at a...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(00)80062-5

    authors： Werwitzke S,Drescher B,Schmidt RE,Witte T

    更新日期：2000-08-01 00:00:00

  • Modulation by adherent cells and irradiation of in vitro LIF production by Con-A stimulated mononuclear cells.

    abstract：:LIF activity production by ConA-stimulated mononuclear cells was tested by measuring granulocyte migration from clotted plasma droplets placed in Microtest II plates. 90 min. incubation of MNC cultures with ConA assured a significant LIF activity in the 24 h. culture supernatants. Removal of the adherent cells after C...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(81)80097-6

    authors： Sandru G,Veraguth P

    更新日期：1981-01-01 00:00:00

  • Circulating complexes of the vitamin D binding protein with G-actin induce lung inflammation by targeting endothelial cells.

    abstract：:This study investigated the actin scavenger function of the vitamin D binding protein (DBP) in vivo using DBP null (-/-) mice. Intravenous injection of G-actin into wild-type (DBP+/+) and DBP-/- mice showed that contrary to expectations, DBP+/+ mice developed more severe acute lung inflammation. Inflammation was restr...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2013.10.001

    authors： Ge L,Trujillo G,Miller EJ,Kew RR

    更新日期：2014-03-01 00:00:00

  • Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1α mRNA.

    abstract：:This study tested the hypothesis that prolonged severe hypoxia during monocyte to macrophage differentiation results in macrophages with a pattern of gene expression and phenotype distinct from those maturing in normal oxygen levels. Macrophages accumulate in hypoxic and anoxic areas within pathological sites such as ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2010.12.005

    authors： Staples KJ,Sotoodehnejadnematalahi F,Pearson H,Frankenberger M,Francescut L,Ziegler-Heitbrock L,Burke B

    更新日期：2011-07-01 00:00:00

  • Nitrite production by activated murine macrophages correlates with their toxoplasmastatic activity, Ia antigen expression, and production of H2O2.

    abstract：:Activated macrophages have various characteristics in common with exudate and resident macrophages, but the ability to inhibit intracellular proliferation of the protozoa Toxoplasma gondii, the expression of Ia antigen and the capacity to produce H2O2 varies among these cells. Assessment of these features of macrophag...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80575-9

    authors： Nibbering PH,Langermans JA,van de Gevel JS,van der Hulst MB,van Furth R

    更新日期：1991-12-01 00:00:00

  • Phagocyte recognition by lectin receptors.

    abstract：:A "lectin-like" receptor for bacterial cell wall sugars, originally described in the membrane of mouse peritoneal macrophages, which facilitates binding of various bacteria to the macrophage surface, has now been shown to be present on most phagocytes from a variety of species. The role of such a receptor in the infla...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(82)80090-9

    authors： Weir DM,Stewart J,Glass E

    更新日期：1982-04-01 00:00:00

  • Ligaria cuneifolia flavonoid fractions modulate cell growth of normal lymphocytes and tumor cells as well as multidrug resistant cells.

    abstract：:Flavonoids are ubiquitous compounds present in plant extracts. They represent a major active component of the plant extract and are often known for their anti-inflammatory and anti-tumor effects. Previously, we demonstrated that Ligaria cuneifolia (R et P) Tiegh. (Loranthaceae) extracts inhibit proliferation of murine...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2005.03.001

    authors： Cerdá Zolezzi P,Fernández T,Aulicino P,Cavaliere V,Greczanik S,Caldas Lopes E,Wagner M,Ricco R,Gurni A,Hajos S,Alvarez E

    更新日期：2005-01-01 00:00:00

  • Lectin complement system and pattern recognition.

    abstract：:Living organisms have strong defense mechanisms against invading microorganisms as survival strategies. One of the defense mechanisms is the complement system, composed of more than 30 serum and cell surface components. This system collaborates in recognition and elimination of pathogens as a part of both the innate a...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2006.01.003

    authors： Endo Y,Takahashi M,Fujita T

    更新日期：2006-01-01 00:00:00

  • The regulatory roles of C1q.

    abstract：:C1q binds to immune complexes to elicit complement-dependent microbial killing and enhance phagocytosis. Besides this classical role, C1q also opsonizes apoptotic cells for clearance by phagocytes. C1q deficiency increases susceptibility to microbial infections and is also associated with elevated autoimmunity as char...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2006.11.008

    authors： Lu J,Wu X,Teh BK

    更新日期：2007-01-01 00:00:00

  • Interferon regulatory factor 3 plays a role in macrophage responses to interferon-γ.

    abstract：:IFN-γ produced during viral infections activates the IFN-γ receptor (IFNGR) complex for STAT1 transcriptional activity leading to expression of Interferon Regulatory Factors (IRF). Simultaneous activation of TBK/IKKε via TLR3 during viral infections activates the transcription factor IRF3. Together these transcription...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2019.04.004

    authors： Guinn ZP,Petro TM

    更新日期：2019-07-01 00:00:00

  • Age-related changes of mitogen responsiveness in different lymphoid organs from outbred NMRI mice.

    abstract：:Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(81)80014-9

    authors： Joncourt F,Bettens F,Kristensen F,de Weck AL

    更新日期：1981-06-01 00:00:00

  • Modulation of Forssman glycosphingolipid expression by murine macrophages: coinduction with class II MHC antigen by the lymphokines IL4 and IL6.

    abstract：:In contrast to murine spleen M phi, resident peritoneal M phi from health mice express very little Forssman glycolipid antigen (Fo). The following experiments suggest that Fo expression by peritoneal M phi may be associated with inflammation. Balb/c and CBA/J mice were given inflammatory stimuli by i.p. injection of l...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(11)80302-5

    authors： von Kleist R,Schmitt E,Westermann J,Mühlradt PF

    更新日期：1990-06-01 00:00:00

  • Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo.

    abstract：:The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25, cytotoxic T lymphoc...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.08.005

    authors： Kreiser S,Eckhardt J,Kuhnt C,Stein M,Krzyzak L,Seitz C,Tucher C,Knippertz I,Becker C,Günther C,Steinkasserer A,Lechmann M

    更新日期：2015-02-01 00:00:00