Up regulation of nitric oxide synthase-nitric oxide system in the testis of rats undergoing autoimmune orchitis.

abstract：:High Mphi:T cell ratios suppress the immune response to the retroviral superantigen Mls by IFNgamma-triggered production of the arg- and trp-consuming enzymes iNOS and IDO. Attempts to reverse suppression by treatment with pro-inflammatory cytokines revealed that IL-6 improved the T cell response to Mls and the pro-he...

journal_title：Immunobiology

authors： Silberman D,Bucknum A,Kozlowski M,Matlack R,Riggs J

更新日期：2010-01-01 00:00:00

abstract：:Shigella spp. are known to penetrate the colonic epithelial cells causing shigellosis, which results in production of convalescent antibodies against porin, the surface exposed major outer membrane protein. Porin has been categorized as primarily TLR2-ligand and here we validated its signaling procedure in colonic INT...

journal_title：Immunobiology

authors： Mukherjee S,Sinha D,Ghosh AK,Biswas T

更新日期：2014-05-01 00:00:00

abstract：:Immunosuppressive effects of corticosteroids are generally known, but the mechanisms influencing the immune system are poorly understood. However, a correlation between cortisol levels and cytokine production has been reported by several investigators. In the present study we determined cortisol concentrations in huma...

journal_title：Immunobiology

authors： Reissland P,Wandinger KP

更新日期：1999-06-01 00:00:00

abstract：:When monocytes are stimulated with LPS (lipopolysaccharide) repeatedly then the initially high expression of the TNF (tumor necrosis factor) gene is only very low, i.e. the cells are tolerant to LPS. Tolerant cells still express the CD14 receptor and they can still be activated to mobilize NF-kappa B into nucleus. Ana...

journal_title：Immunobiology

authors： Frankenberger M,Ziegler-Heitbrock HW

更新日期：1997-12-01 00:00:00

abstract：:Based on our findings that HIV-1 gp41 independently of CD4 can bind to the human helper T lymphoid cell line H9, B cell line Raji and monocyte cell line U937, we characterized putative binding of HIV-1 gp41 to human peripheral blood lymphocytes (PBLs) and monocytes. Using flow cytometry (FACS), we demonstrated that th...

journal_title：Immunobiology

authors： Chen YH,Böck G,Vornhagen R,Steindl F,Katinger H,Dierich MP

更新日期：1993-08-01 00:00:00

abstract：:Immunocytochemical studies on both the light-microscopic and electron-microscopic levels proved that peritoneal resident macrophages derive from a precursor cell in the bone marrow. Evidence that this precursor cell differs from that of the monocyte is described. Progenitor cells of peritoneal resident macrophages wer...

journal_title：Immunobiology

authors： Daems WT,de Bakker JM

更新日期：1982-04-01 00:00:00

abstract：:We utilized antisera specific for murine IL 1 alpha and IL 1 beta proteins to characterize cell-associated IL 1 according to two distinct criteria, immunochemical detection of radiolabeled IL 1 polypeptides and inhibition of IL 1 activity in cell lysates. Evidence is presented that IL 1 alpha and IL 1 beta are each sy...

journal_title：Immunobiology

authors： Günther C,Röllinghoff M,Beuscher HU

更新日期：1989-02-01 00:00:00

abstract：:Immunological mechanisms of hygiene hypothesis are expected to develop a novel strategy for allergy prevention. Although a large number of studies has investigated the relation between allergies and infection, little is known about the influence of the exposure to infections on antigen uptake by dendritic cells (DCs)....

journal_title：Immunobiology

authors： Mizuno N,Sasaki Y,Segawa R,Asakawa S,Hiratsuka M,Hirasawa N

更新日期：2018-01-01 00:00:00

abstract：:Gaucher disease (GD) is associated with upregulation of CD1d and MHC-class II expression by monocytes. While the physiological impact of CD1d upregulation remains uncertain, it has been proposed that MHC-class II upregulation is associated with inflammation. Hereby, we show that the decrease in MHC-class II expression...

journal_title：Immunobiology

authors： Balreira A,Cavallari M,Sá Miranda MC,Arosa FA

更新日期：2010-06-01 00:00:00

abstract：:In this study the SEB-activated LAK cytotoxicity was identified and characterized in human peripheral blood lymphocytes (PBMC). After 3 days of SEB stimulation, the PBMC acquired a cytotoxicity against traditional LAK targets, K-562 and Daudi, beside that human glomerular endothelial cells (HGEC) were effectively lyse...

journal_title：Immunobiology

authors： Seprényi G,Shibata T,Onody R,Kohsaka T

更新日期：1997-06-01 00:00:00

abstract：:Infectious bursal disesase is a highly contagious, wide spread immunosuppressive chicken disease caused by the Infectious Bursal Disease Virus (IBDV). IBDV is a two segmented double-strand RNA virus, member of the Birnaviridae family. In order to study the interaction between IBDV and the immune system, chickens were ...

journal_title：Immunobiology

authors： Carballeda JM,Zoth SC,Gómez E,Gravisaco MJ,Berinstein A

更新日期：2011-09-01 00:00:00

abstract：:To differentiate severe congenital neutropenia (SCN) from autoimmune neutropenia (AIN) in patients with persistent neutropenia ≤1000/mm(3) over three months, we evaluated anti-neutrophil auto-antibodies, candidate genes of ELANA, HAX1 and GCSFR, and neutrophil elastase (NE) activity in 38 patients (21 females; average...

journal_title：Immunobiology

authors： Lee WI,Chen SH,Huang JL,Jaing TH,Chung HT,Yeh KW,Chen LC,Yao TC,Hsieh MY,Lin SJ,Kuo ML

更新日期：2013-05-01 00:00:00

abstract：:Cryptococcus neoformans is a pathogenic fungus causing life threatening infections in humans. The present in vitro study aimed to investigate the opsonizing properties of a well characterized serum ficolin (rat ficolin-A), a member of carbohydrate-recognition molecules of the innate immune system, in the defence again...

journal_title：Immunobiology

authors： Schelenz S,Kirchhof N,Bidula S,Wallis R,Sexton DW

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:The interaction between the immune system and malignant diseases is a proven key target for cancer therapy. We describe an innovative 3D cell culture system comprising both immune and cancer cells to evaluate their interaction and immune cell infiltration to provide an innovative in vitro screening of immu...

journal_title：Immunobiology

authors： Koeck S,Zwierzina M,Huber JM,Bitsche M,Lorenz E,Gamerith G,Dudas J,Kelm JM,Zwierzina H,Amann A

更新日期：2016-05-01 00:00:00

abstract：:Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...

journal_title：Immunobiology

authors： Joncourt F,Bettens F,Kristensen F,de Weck AL

更新日期：1981-06-01 00:00:00

abstract：:Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the TLRs are of considerable interest. Here we seek to determine the molecular mechanism by ...

journal_title：Immunobiology

authors： Zsengellér ZK,Gerard NP

更新日期：2020-03-01 00:00:00

abstract：:Equine dendritic cells (eqDC) can be generated from peripheral blood monocytes by propagation in GM-CSF and IL-4. Despite similarities with the generation of human DC, we found significant improvements for eqDC generation and functional influences on eqDC maturation. The fractionation of peripheral blood mononuclear c...

journal_title：Immunobiology

authors： Dietze B,Cierpka E,Schäfer M,Schill W,Lutz MB

更新日期：2008-01-01 00:00:00

abstract：:Erythrocytes from paroxysmal nocturnal hemoglobinuria patients (PNH-E) are much more susceptible to lysis by acid-activated human serum than normal human erythrocytes. Acidification of normal human serum to pH 6.4 in the absence of erythrocytes generates this lytic activity independently of the alternative pathway of ...

journal_title：Immunobiology

authors： Hänsch G,Hammer C,Jiji R,Rother U,Shin M

更新日期：1983-03-01 00:00:00

abstract：:Pythiosis is a life-threatening disease caused by the fungus-like microorganism Pythium insidiosum that can lead to death if not treated. Since P. insidiosum has particular cell wall characteristics, pythiosis is difficult to treat, as it does not respond well to traditional antifungal drugs. In our study, we investig...

journal_title：Immunobiology

authors： Ledur PC,Tondolo JSM,Jesus FPK,Verdi CM,Loreto ÉS,Alves SH,Santurio JM

更新日期：2018-03-01 00:00:00

abstract：:Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effec...

journal_title：Immunobiology

authors： Worthington JJ,Fenton TM,Czajkowska BI,Klementowicz JE,Travis MA

更新日期：2012-12-01 00:00:00

abstract：:The tumor suppressor protein P53 is strongly involved in orchestrating cellular defenses in the diverse variety of human tissues. Anomalies to lung endothelium permeability are streaming severe consequences towards human health, often associated with fatal outcomes. Ongoing investigations suggest that P53 exerts a pro...

journal_title：Immunobiology

authors： Uddin MA,Akhter MS,Siejka A,Catravas JD,Barabutis N

更新日期：2019-07-01 00:00:00

abstract：:IL-33 targeting ST2 receptor (T1/ST2), expressed on Th2 cell surface, regulates the production of cytokines like IL-17A and IL-31. We studied the role of IL-33/ST2 axis in IL-31 and IL-17A production in patients with allergic rhinitis (AR) and with concomitant allergic asthma and rhinitis (AAR). 20 healthy control sub...

journal_title：Immunobiology

authors： Vocca L,Di Sano C,Uasuf CG,Sala A,Riccobono L,Gangemi S,Albano GD,Bonanno A,Gagliardo R,Profita M

更新日期：2015-08-01 00:00:00

abstract：CONTEXT:The PDS gene (SLC26A4) is responsible for Pendred syndrome (PS). Genetic analysis of PDS using Tunisian samples showed evidence for linkage and association with autoimmune thyroid diseases (AITD) emergence. In addition, the PDS gene product, pendrin, was recently identified as a novel autoantigen in Graves' dis...

journal_title：Immunobiology

authors： Belguith-Maalej S,Rebuffat SA,Charfeddine I,Mnif M,Nadir RF,Abid M,Ghorbel A,Peraldi-Roux S,Ayadi H,Hadj-Kacem H

更新日期：2011-05-01 00:00:00

abstract：:Understanding the mechanisms governing the type of induced immune response after microbial invasion, could be of crucial importance for the rational design of a bacteria-based vaccine. Targeting a vaccine directly to dendritic cells (DCs), which are considered the most powerful antigen presenting cells, could be extre...

journal_title：Immunobiology

authors： Rescigno M,Rotta G,Valzasina B,Ricciardi-Castagnoli P

更新日期：2001-12-01 00:00:00

abstract：PROBLEM:NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. METHODS OF STUDY:Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present stud...

journal_title：Immunobiology

authors： Dons'koi BV,Chernyshov VP,Sirenko VY,Strelko GV,Osypchuk DV

更新日期：2014-03-01 00:00:00

abstract：:The concept of using mesenchymal stem cells (MSCs) in bone repair has progressively evolved, and the goal of cell-mediated therapy is to prolong the natural physiological abilities of healing, or substitute them, when these are lacking, failing, or progressing too slowly. The future application of MSCs in human therap...

journal_title：Immunobiology

authors： Zhang X,Tang T,Shi Q,Fernandes JC,Dai K

更新日期：2009-01-01 00:00:00

abstract：:Paracoccidioides brasiliensis is a dimorphic fungus from the Paracoccidioides genus, which is the causative agent of paracoccidioidomycosis, a chronic, subacute or acute mycosis, with visceral and cutaneous involvement. This disease that is acquired through inhalation primarily attacks the lungs but, can spread to oth...

journal_title：Immunobiology

authors： Bachiega TF,Dias-Melicio LA,Fernandes RK,de Almeida Balderramas H,Rodrigues DR,Ximenes VF,de Campos Soares ÂM

更新日期：2016-02-01 00:00:00

abstract：:Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study,...

journal_title：Immunobiology

authors： Ogita T,Bergamo P,Maurano F,D'Arienzo R,Mazzarella G,Bozzella G,Luongo D,Sashihara T,Suzuki T,Tanabe S,Rossi M

更新日期：2015-06-01 00:00:00

abstract：:The phenotype frequency of the platelet-specific antigens P1A1/A2 ( = Zw(a,b)) in the German population (N = 711) is 97.75% and 2.25% respectively. The corresponding gene frequencies are P1A1 0.85; P1A2 0.15. The P1A1 determinant is codominantly inherited (19 families; 151 family members). There is a strong gene dosag...

journal_title：Immunobiology

authors： Mueller-Eckhardt C,Marks HJ,Baur MP,Mueller-Eckhardt G

更新日期：1982-02-01 00:00:00

abstract：:Regulatory T cells that express CD39 (CD39+ Treg) exhibit specific immunomodulatory properties. Ectonucleotidase CD39 hydrolyses ATP and ADP. ATP is a ligand of the P2X7 receptor and induces the shedding of CD62L and apoptosis. However, the role of ATP in CD39+ Treg cells has not been defined. Furthermore, NAD can act...

journal_title：Immunobiology

authors： Cortés-Garcia JD,López-López C,Cortez-Espinosa N,García-Hernández MH,Guzmán-Flores JM,Layseca-Espinosa E,Portales-Cervantes L,Portales-Pérez DP

更新日期：2016-01-01 00:00:00