Lysis of paroxysmal nocturnal hemoglobinuria erythrocytes by acid-activated serum.

abstract：:Kinetic methods can provide significant information concerning the mechanism of cellular cytotoxicity reactions. Previous kinetic studies of cytotoxic T lymphocytes (Tc) have been hampered by the heterogeneity of the effector cell population tested. We therefore examined the kinetics of lysis mediated by cloned, IL 2 ...

journal_title：Immunobiology

authors： Callewaert DM,Meyers P,Hiernaux J,Radcliff G

更新日期：1988-12-01 00:00:00

abstract：:Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important...

journal_title：Immunobiology

authors： Burke B

更新日期：2004-01-01 00:00:00

abstract：:Anti-anaemic drug ferric-sorbitol citrate showed immunomodulatory effects, activating NF-kappaB in peritoneal macrophages, which consequently secrete tumour necrosis factor-alpha (TNF-alpha). TNF-alpha activates NF-kappaB in spleen cells. The aim of this study was to investigate the effect of iron polyisomaltosate, an...

journal_title：Immunobiology

authors： Poljak-Blazi M,Jaganjac M,Mustapic M,Pivac N,Muck-Seler D

更新日期：2009-01-01 00:00:00

abstract：:Non-antigen-specific activation of human B lymphocytes for IgE production in vitro requires the presence of interleukin 4 and non-cognate physical interaction with T cells. The latter can be replaced by antibodies directed against the B cells' CD40 structure. Antigen-specific induction of immunoglobulin responses, inc...

journal_title：Immunobiology

authors： Armerding D,van Reijsen FC,Hren A,Mudde GC

更新日期：1993-07-01 00:00:00

abstract：:Cell walls from Streptococcus pyogenes strain Sv (Group A, M type 3) were lysed with M1 endo-N-acetylmuramidase, and the group A-specific carbohydrate antigen was purified by Sephadex G-100 gel filtration. The initial eluting antigen (M1gA) peak was assessed for mitogenic and polyclonal lymphocyte-activating propertie...

journal_title：Immunobiology

authors： Morisaki I,Kimura S,Torii M,Michalek SM,McGhee JR,Okahashi N,Hamada S

更新日期：1985-11-01 00:00:00

abstract：:Glypican-3 (GPC3) is an attractive target for chimeric antigen receptor (CAR)-T cell therapy, as it is overexpressed in most hepatocellular carcinoma (HCC) tissues but shows restricted expression in healthy adult tissues. Herein, we generated GPC3-specific CAR-T cells for HCC therapy by electroporation with plasmid DN...

journal_title：Immunobiology

authors： Wang P,Qin W,Liu T,Jiang D,Cui L,Liu X,Fang Y,Tang X,Jin H,Qian Q

更新日期：2020-01-01 00:00:00

abstract：:A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3d...

journal_title：Immunobiology

authors： Ling NR,Brown B

更新日期：1992-08-01 00:00:00

abstract：:IL-33 targeting ST2 receptor (T1/ST2), expressed on Th2 cell surface, regulates the production of cytokines like IL-17A and IL-31. We studied the role of IL-33/ST2 axis in IL-31 and IL-17A production in patients with allergic rhinitis (AR) and with concomitant allergic asthma and rhinitis (AAR). 20 healthy control sub...

journal_title：Immunobiology

authors： Vocca L,Di Sano C,Uasuf CG,Sala A,Riccobono L,Gangemi S,Albano GD,Bonanno A,Gagliardo R,Profita M

更新日期：2015-08-01 00:00:00

abstract：:We examined the cell cycle distribution and subset marker characteristics of mucosal-associated supramammary lymph node (MALN) T cell subpopulations at sites proximal and distal to the mammary region of animals repeatedly injected with Staphylococcus aureus antigen. Multiparameter flow cytometric analysis of draining ...

journal_title：Immunobiology

authors： Dobrzanski MJ,Yang TJ

更新日期：1992-06-01 00:00:00

abstract：:The innate immune system recognizes pathogen-associated molecular patterns (PAMP) to cope with evolving infections. Toll-like receptors (TLRs) play a pivotal role in recognition of PAMPs. In the course of infection not a single but rather a full panel of different microbial components interacts with distinct TLRs simu...

journal_title：Immunobiology

authors： Dalpke AH,Frey M,Morath S,Hartung T,Heeg K

更新日期：2002-10-01 00:00:00

abstract：:We studied local events in the popliteal lymph nodes of CD4-deficient mice following foot pad injection with an MMTV strain which carries the gene for a V beta 14-specific superantigen. Injection of the V beta 14-specific MMTV induced vigorous expansion of V beta 14+ CD4+ T cells and B cells in their lymph nodes of CD...

journal_title：Immunobiology

authors： Ando Y,Wajjwalku W,Kishihara K,Arai T,Niimi N,Hiromatsu K,Morishima T,Yoshikai Y

更新日期：1996-08-01 00:00:00

abstract：:When monocytes are stimulated with LPS (lipopolysaccharide) repeatedly then the initially high expression of the TNF (tumor necrosis factor) gene is only very low, i.e. the cells are tolerant to LPS. Tolerant cells still express the CD14 receptor and they can still be activated to mobilize NF-kappa B into nucleus. Ana...

journal_title：Immunobiology

authors： Frankenberger M,Ziegler-Heitbrock HW

更新日期：1997-12-01 00:00:00

abstract：:CD147 is a broadly expressed cell surface molecule of the immunoglobulin superfamily whose expression is up-regulated upon T cell activation. Engagement of CD147 by CD147 monoclonal antibodies (mAbs) has been shown to induce homotypic aggregation of U937 cells. To study intracellular signal transduction induced by the...

journal_title：Immunobiology

authors： Khunkeawla P,Moonsom S,Staffler G,Kongtawelert P,Kasinrerk W

更新日期：2001-05-01 00:00:00

abstract：:Mycoplasma arthritidis produces a so-far only partially characterized soluble material (MAS) that has a potent mitogenic effect on T lymphocytes of several species. Similar to staphylococcal enterotoxins and a number of related toxins secreted by other species of bacteria, nanogram quantities of these so-called supera...

journal_title：Immunobiology

authors： Brand JM,Kirchner H,Neustock P,Kruse A

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:To investigate the close association between different antiphospholipid antibodies (aPL) caused by infection and their appearance together with a prolonged activated partial thromboplastin time (aPTT). METHODS:Sera from 122 children were evaluated in this study. Thirty-seven children with mild to medium prol...

journal_title：Immunobiology

authors： Frauenknecht K,Lackner K,von Landenberg P

更新日期：2005-01-01 00:00:00

abstract：:Infection of human monocytes with influenza A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis. The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorl...

journal_title：Immunobiology

authors： Bussfeld D,Bacher M,Moritz A,Gemsa D,Sprenger H

更新日期：1997-12-01 00:00:00

abstract：:Infectious bursal disesase is a highly contagious, wide spread immunosuppressive chicken disease caused by the Infectious Bursal Disease Virus (IBDV). IBDV is a two segmented double-strand RNA virus, member of the Birnaviridae family. In order to study the interaction between IBDV and the immune system, chickens were ...

journal_title：Immunobiology

authors： Carballeda JM,Zoth SC,Gómez E,Gravisaco MJ,Berinstein A

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:NK cells as a part of innate immune system, are controlled by a set of activating and inhibitory KIR receptors (aKIR, iKIR) which are implicated in tumor microenvironment immunity through a variety of activating and inhibitory immune signals. KIRs are multi gene family receptors that differ in the number and...

journal_title：Immunobiology

authors： Barani S,Taghipour M,Ghaderi A

更新日期：2020-03-01 00:00:00

abstract：:Immunization using human papilloma virus (HPV)-L1 virus-like particles (VLPs) induces a robust and effective immune response, which has recently resulted in the implementation of the HPV-L1 VLP vaccination in health programs. However, during infection, HPV can escape immune surveillance leading to latency and disease....

journal_title：Immunobiology

authors： de Witte L,Zoughlami Y,Aengeneyndt B,David G,van Kooyk Y,Gissmann L,Geijtenbeek TB

更新日期：2007-01-01 00:00:00

abstract：:Dogs with lymphoma are established as good model for human non-Hodgkin lymphoma studies. Canine cell lines derived from lymphomas may be valuable tools for testing new therapeutic drugs. In this context, we established a canine T-cell line, PER-VAS, from a primary aggressive T-cell lymphoma with large granular morphol...

journal_title：Immunobiology

authors： Bonnefont-Rebeix C,Fournel-Fleury C,Ponce F,Belluco S,Watrelot D,Bouteille SE,Rapiteau S,Razanajaona-Doll D,Pin JJ,Leroux C,Marchal T

更新日期：2016-01-01 00:00:00

abstract：:By quantitative and functional methods, changes were assessed in NK(ASGM-1+) cell numbers and NK cell-mediated lytic function of the spleen and bone marrow of mice bearing a tumor of hemopoietic origin (FLV-induced erythroleukemia) for 9 days +/- simultaneous administration of indomethacin (10 micrograms/ml drinking w...

journal_title：Immunobiology

authors： Christopher FL,Dussault I,Miller SC

更新日期：1991-12-01 00:00:00

abstract：:The distribution of membrane-associated nucleotide pyrophosphatase activity has been investigated on mouse leucocytes of different origin. It is shown that enzyme-specific activity is higher on bone-marrow cells than on cells derived from peripheral organs. Since thymus lymphocytes show the lowest activity, it is obvi...

journal_title：Immunobiology

authors： Brockhaus A,Bösing-Schneider R,Sund H

更新日期：1982-01-01 00:00:00

abstract：:We examined the expression of seven V alpha or V beta T cell receptor (TCR) segments on human CD4+ and CD8+ T cells. Confirming previously published results, we found a preferential expression of four V segment gene products on CD4+ T cells. One of these markers (V beta 6.7) was constantly expressed on more CD4+ T cel...

journal_title：Immunobiology

authors： Dannecker G,Mecheri S,Heuser M,Ihle J,Hoffmann MK,Niethammer D

更新日期：1993-01-01 00:00:00

abstract：:The century-old tuberculosis vaccine BCG has been the focus of renewed interest due to its well-documented ability to protect against various non-TB pathogens. Much of these broad spectrum protective effects are attributed to trained immunity, the epigenetic and metabolic reprogramming of innate immune cells. As BCG v...

journal_title：Immunobiology

authors： Moulson AJ,Av-Gay Y

更新日期：2020-12-24 00:00:00

abstract：:Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the TLRs are of considerable interest. Here we seek to determine the molecular mechanism by ...

journal_title：Immunobiology

authors： Zsengellér ZK,Gerard NP

更新日期：2020-03-01 00:00:00

abstract：:People deficient in C1-INH present recurrent angioedema localized to subcutaneous or mucous tissues. The defect can be caused by impaired synthesis, due to a genetic defect (hereditary angioedema), or by increased catabolism (acquired angioedema). In our experience the majority of patients with acquired angioedema (16...

journal_title：Immunobiology

authors： Cicardi M,Bergamaschini L,Cugno M,Beretta A,Zingale LC,Colombo M,Agostoni A

更新日期：1998-08-01 00:00:00

abstract：:Neutrophils, the most abundant leukocyte in human circulation are being more and more recognized as part of the immune reaction to cancer. In the last years, the understanding that neutrophils possess a dual role in cancer development has emerged. During tumor progression the number of neutrophils increase, and their ...

journal_title：Immunobiology

authors： Mishalian I,Granot Z,Fridlender ZG

更新日期：2017-01-01 00:00:00

abstract：:A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of ...

journal_title：Immunobiology

authors： Peranzoni E,Marigo I,Dolcetti L,Ugel S,Sonda N,Taschin E,Mantelli B,Bronte V,Zanovello P

更新日期：2007-01-01 00:00:00

abstract：:Chromosome 1 of the mouse carries a number of genes for alloantigens which can be recognized by T cells, among those the mixed lymphocyte stimulation (Mls) locus and the lymphocyte stimulating determinant (Lsd) locus have been described. The Relationship between the antigens coded for by these two loci has been furthe...

journal_title：Immunobiology

authors： Goldbach J,Prahl H,Stäb F,Steinhausen D,Kölsch E

更新日期：1988-05-01 00:00:00

abstract：:"Brucelline INRA" is an aqueous extract of a rough strain of Brucella melitensis that is used to test cutaneous delayed hypersensitivity in man and animals. The cellular response of mice (either normal, or sensitized by a previous brucella infection) was investigated with local implanted "cell-traps" and by immunologi...

journal_title：Immunobiology

authors： Bureau JP,Caravano R,Garelli L,Lemaire J

更新日期：1989-03-01 00:00:00