Abstract：
:Neutrophils, the most abundant leukocyte in human circulation are being more and more recognized as part of the immune reaction to cancer. In the last years, the understanding that neutrophils possess a dual role in cancer development has emerged. During tumor progression the number of neutrophils increase, and their phenotype change. In advanced cancer, we can find several sub-populations of circulating neutrophils possessing different characteristics of maturity, tumor cytotoxicity and immune suppression. One important sub-population of circulating neutrophils is the granulocytic myeloid derived suppressor cells (G-MDSC). Differencing G-MDSC from other sub-populations of neutrophils in the circulation is a complex and controversial task, as there are no clear definitions of the differences between these granulocytic sub-populations. Herein we review the differences described thus far between G-MDSC and other circulating neutrophils. We then compare the morphology, surface markers, function and prognostic importance of the different tumor-related circulating neutrophils, as described by us and others, and discuss the possible relations between the different sub-populations, their source and fate. Lastly, we suggest a nomenclature to try and encompass the full range of circulating neutrophils in cancer.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Mishalian I,Granot Z,Fridlender ZGdoi
10.1016/j.imbio.2016.02.001subject
Has Abstractpub_date
2017-01-01 00:00:00pages
82-88issue
1eissn
0171-2985issn
1878-3279pii
S0171-2985(16)30017-1journal_volume
222pub_type
杂志文章,评审相关文献
IMMUNOBIOLOGY文献大全abstract：:The supernatant from cultures of T cell clones derived from (BALB/c----C3H/He) chimeras suppresses BALB/c anti-C3H/He or BALB/c anti-C57BL/6 MLRs. When we studied the alloantigen specificity of the suppressor activity in culture supernatant, we observed three types of the suppressor activity (i.e., the suppressor acti...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(88)80095-0
更新日期：1988-04-01 00:00:00
abstract：:Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2018.07.005
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs. OBJECTIVES:The present study investigates the association between immune response and decline in lung function...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2011.02.003
更新日期：2011-08-01 00:00:00
abstract：:C1r, the enzyme responsible for intrinsic activation of the C1 complex of complement, is a modular serine protease featuring an overall structural organization homologous to those of C1s and the mannan-binding lectin-associated serine proteases (MASPs). This review will initially summarize current information on the s...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1078/0171-2985-00139
更新日期：2002-09-01 00:00:00
abstract：:Beside the lung, thoracic lymph nodes are most affected during silicosis. The mechanisms leading to enlargement of the lymph nodes and partial activation of lymph node cells are still unclear. The present study demonstrates an increase in iNOS mRNA expression in the lung draining lymph nodes of rats at 1, 2, and 8 mon...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1078/0171-2985-00127
更新日期：2002-07-01 00:00:00
abstract：:It is commonly accepted that dendritic cells (DCs) play a pivotal role in the induction of adaptive T cell-mediated immune responses. The clonal expansion of antigen-specific T cells within secondary lymphoid organs reflects the efficiency of antigen processing and presentation by DCs. Consequently, the quantification...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2010.05.017
更新日期：2010-09-01 00:00:00
abstract：:The distribution of MEL-14+ lymphocytes was investigated by both fluorocytometric analysis and complement-dependent-cellular-cytotoxicity (CDCC) tests in which rabbit anti-rat Ig was added with complement at a secondary step. When CDCC was employed to detect MEL-14+ cells, almost half of the thymocytes were found to b...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(11)80200-7
更新日期：1991-03-01 00:00:00
abstract：:T cells play a pivotal role in controlling the immune response and have been the focus of extensive research. We studied the process of in vitro generation of antigen-specific T effector cells (Teffs) to assess the dynamics of antigen presentation and determine the best conditions for cell therapy. We used a peptidic ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2016.04.001
更新日期：2016-08-01 00:00:00
abstract：:Chromosome 1 of the mouse carries a number of genes for alloantigens which can be recognized by T cells, among those the mixed lymphocyte stimulation (Mls) locus and the lymphocyte stimulating determinant (Lsd) locus have been described. The Relationship between the antigens coded for by these two loci has been furthe...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(88)80037-8
更新日期：1988-05-01 00:00:00
abstract：:BASILEA rabbits lack the expression of chi-polypeptide chains and compensate for this lack with expression of lambda polypeptide light chains. These rabbits were immunized with streptococcal group A-variant vaccines. The heterogeneity of the lambda polypeptide chains of specific antibodies was analyzed and compared wi...
journal_title：Immunobiology
pub_type： 杂志文章
doi：
更新日期：1979-08-01 00:00:00
abstract：:Chronic rhinosinusitis is an inflammatory process of the mucous membrane of the nasal cavity and paranasal sinuses, presenting with two phenotypes that differ in symptoms and inflammatory profiles: either with or without polyps. Natural killer (NK) cells are involved in both the innate and acquired immune response, an...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2019.11.025
更新日期：2020-03-01 00:00:00
abstract：:Complement assays have for many years utilised buffers based on barbitone (veronal) despite the well-recognised toxicity of this agent and the tight regulations on its use in most countries. The use of barbitone in complement assay buffers is steeped in history, from a time when no other suitable buffers were availabl...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2018.07.016
更新日期：2018-12-01 00:00:00
abstract：:Living organisms have strong defense mechanisms against invading microorganisms as survival strategies. One of the defense mechanisms is the complement system, composed of more than 30 serum and cell surface components. This system collaborates in recognition and elimination of pathogens as a part of both the innate a...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2006.01.003
更新日期：2006-01-01 00:00:00
abstract：:CD40 is essential for optimal B cell activation. It has been shown that CD40 stimulation can augment BCR-induced B cell responses, but the molecular mechanism(s) by which CD40 regulates BCR signaling is poorly understood. In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2010.09.016
更新日期：2011-05-01 00:00:00
abstract：:Periodontitis is a chronic oral pathology caused by impaired immune response against oral bacteria resulting in tissue inflammation and damage. Among the members of innate immune response, the first line of defence against pathogens, inflammasomes are macro-molecular protein complexes that can be activated by differen...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2017.01.001
更新日期：2017-05-01 00:00:00
abstract：:The prevailing paradigm defines sarcoidosis as a disease of unknown etiology characterized by a systemic noncaseating epithelioid granulomatous response (SGR). This formulation fails to account for the elusiveness of the etiological agent, the nature of the Kveim response, the paradox of cutaneous delayed type hyperse...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2016.12.005
更新日期：2017-04-01 00:00:00
abstract：:A C1q receptor that upregulates the phagocytic capacity of professional phagocytes, C1qRp, has been identified, and its primary structure determined by cDNA cloning and sequencing. Monoclonal antibodies that immunoprecipitate this 126,000 Mr polypeptide inhibit the enhancement of phagocytosis triggered not only by C1q...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/S0171-2985(98)80031-4
更新日期：1998-08-01 00:00:00
abstract：:Memory T cells producing interferon (IFN)γ and expressing very late antigen-1 (VLA-1) integrin collagen receptors are found in carotid atherosclerotic plaques, suggesting their involvement in coronary artery disease (CAD) as well. To determine the role of VLA-1+ T cells in CAD percent of CD3+ T cells binding monoclona...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2013.11.005
更新日期：2014-04-01 00:00:00
abstract：:Canine visceral leishmaniasis (CVL) is known to affect the cellular immunity of infected dogs, through impairing lymphoproliferation and microbicidal mechanisms. This study examined heme oxygenase-1 (HO-1) and its metabolites, oxidative stress and IL-10 levels in CVL and investigated correlations between these paramet...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2016.12.006
更新日期：2017-05-01 00:00:00
abstract：:Fifty-nine patients with metastatic malignant melanoma were entered into a phase II trial of recombinant alpha-2 interferon given in a dosage of 10 million IU/M2 subcutaneously three times per week for one year. Forty-five of these were evaluable for response. Of five evaluable patients with ocular primaries, none res...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(86)80109-7
更新日期：1986-09-01 00:00:00
abstract：:Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxi...
journal_title：Immunobiology
pub_type： 杂志文章
doi：
更新日期：1979-09-01 00:00:00
abstract：:Tumor necrosis factor superfamily (TNFSF) represents a group of multifunctional inflammatory cytokines that have been shown to participate in a variety of pathological and immunological process. However, the functions of these proteins in oyster are still poorly understood. In the present study, an oyster TNF homolog ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2017.02.002
更新日期：2017-05-01 00:00:00
abstract：:Integration of cellular and humoral arms of the innate immune response is fundamental to the development of powerful effector functions in host defence as well as aberrant immune responses. Here, we provide evidence in support of the relationship between complement activation and NK cell functional modulation. We demo...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2014.03.018
更新日期：2014-09-01 00:00:00
abstract：:Immunocytochemical studies on both the light-microscopic and electron-microscopic levels proved that peritoneal resident macrophages derive from a precursor cell in the bone marrow. Evidence that this precursor cell differs from that of the monocyte is described. Progenitor cells of peritoneal resident macrophages wer...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/S0171-2985(82)80075-2
更新日期：1982-04-01 00:00:00
abstract：:Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2016.11.013
更新日期：2017-06-01 00:00:00
abstract：:Immunosuppressive effects of corticosteroids are generally known, but the mechanisms influencing the immune system are poorly understood. However, a correlation between cortisol levels and cytokine production has been reported by several investigators. In the present study we determined cortisol concentrations in huma...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(99)80072-2
更新日期：1999-06-01 00:00:00
abstract：:To differentiate severe congenital neutropenia (SCN) from autoimmune neutropenia (AIN) in patients with persistent neutropenia ≤1000/mm(3) over three months, we evaluated anti-neutrophil auto-antibodies, candidate genes of ELANA, HAX1 and GCSFR, and neutrophil elastase (NE) activity in 38 patients (21 females; average...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2012.09.001
更新日期：2013-05-01 00:00:00
abstract：:Several, and not necessarily alternative, pathogenic mechanisms have been suggested to sustain the thrombophilic diathesis of the anti-phospholipid syndrome. Among them, interference of anti-phospholipid antibodies with cell acting in the coagulation cascade likely plays a major role. Anti-phospholipid antibodies have...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1078/0171-2985-00211
更新日期：2003-01-01 00:00:00
abstract：:In this study, the effect of sixteen different enzymes on serum C1 and its subcomponents was investigated. The sixteen enzymes could be divided into three groups. First, enzymes which activate native C1: trypsin (optimal concentration 2.4 x 10(-4) mM); alpha-chymotrypsin (2.3 x 10(3) mM); thrombin (1.0 x 10(-5) mM); p...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(83)80058-8
更新日期：1983-08-01 00:00:00
abstract：:The defective antigen presenting ability of antigen presenting cells (APCs) modulates host cytokines and co-stimulatory signals that may lead to severity of leprosy. In the present study, we sought to evaluate the phenotypic features of APCs along with whether DC SIGN (DC-specific intercellular adhesion molecule-grabb...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2013.05.004
更新日期：2013-12-01 00:00:00
