Light chain heterogeneity of type lambda anti-streptococcal group A-variant polysaccharide antibodies in rabbits.

abstract：:The course of legionella pneumonia in guinea pigs after infection with various quantities of virulent L. pneumophila serogroup 1 organisms by aerosol exposure was investigated. The clinical course, histopathological characteristics, manifestations in the lungs and clearance of the legionella organisms from the lungs a...

journal_title：Immunobiology

authors： Twisk-Meijssen MJ,Meenhorst PL,van Cronenburg BJ,Mulder JD,Scheffer E,van Furth R

更新日期：1987-12-01 00:00:00

abstract：:Human Lymphocyte Associated Antigen-1 (LFA-1, CD11a/CD18, alpha L/beta 2) and p150,95 (CD11c/CD18, alpha X/beta 2) are cell surface alpha/beta heterodimers that, together with Mac-1 (CD11b/CD18, alpha M/beta 2) comprise the leukocyte-restricted beta 2 subfamily of integrins. LFA-1 is the only integrin expressed on all...

journal_title：Immunobiology

authors： López-Rodríguez C,Nueda A,Rubio M,Corbí AL

更新日期：1995-07-01 00:00:00

abstract：:We were able to characterize about 25 antigenic proteins of cultured synovial fibroblasts with apparent molecular weights of 15-230 kd by SDS-electrophoresis and immunoblotting using guinea pig antiserum. Some of these proteins were bovine-serum-derived, adsorbed onto fibroblasts from culture medium. Both rheumatoid a...

journal_title：Immunobiology

authors： Heino J,Kouri T,Jalkanen M,Lehtonen OP

更新日期：1984-05-01 00:00:00

abstract：:Peritoneal exudate T lymphocytes (PETLs) that mediate delayed-type hypersensitivity (DTH) to sheep red blood cells in mice were modified by in vitro treatment methods which modify surface carbohydrate constituents. Neuraminidase treatment resulted in the release of both N-acetylneuraminic acid and N-glycolyl-neuramini...

journal_title：Immunobiology

authors： Kaufmann SH,Schauer R,Hahn H

更新日期：1981-01-01 00:00:00

abstract：:We have previously shown that human peripheral blood lymphocytes that do not adhere to natural killer (NK)-sensitive target cell monolayers are at least partially depleted of NK activity. To demonstrate directly that NK effector cells adhere to the monolayers, we have now recovered the adherent populations by treatmen...

journal_title：Immunobiology

authors： Jensen PJ,Koren HS

更新日期：1982-05-01 00:00:00

abstract：:Although there have been numerous attempts to develop a successful vaccine against leishmaniasis, based on the clinical trial in this field, no vaccine against Leishmania in routine way can be found for globally effective vaccination in human. Amongst, first generation vaccines consisting of parasite fractions or whol...

journal_title：Immunobiology

authors： Jafari I,Heravi Shargh V,Shahryari M,Abbasi A,Jaafari MR,Khamesipour A,Badiee A

更新日期：2018-01-01 00:00:00

abstract：:Macrophages are key players not only during initiation of inflammation but also during its resolution. This is achieved by their high functional plasticity and the demand to recognize an enormous repertoire of danger signals and cytokines/chemokines derived from adaptive immune cells. Studies predominantly conducted o...

journal_title：Immunobiology

authors： Ley S,Weigert A,Brüne B

更新日期：2010-09-01 00:00:00

abstract：:Erythrocytes from paroxysmal nocturnal hemoglobinuria patients (PNH-E) are much more susceptible to lysis by acid-activated human serum than normal human erythrocytes. Acidification of normal human serum to pH 6.4 in the absence of erythrocytes generates this lytic activity independently of the alternative pathway of ...

journal_title：Immunobiology

authors： Hänsch G,Hammer C,Jiji R,Rother U,Shin M

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:Male reproductive tract infection and inflammation are important aetiological factors of infertility. Experimental Autoimmune Orchitis (EAO) is a model of chronic inflammation useful to study mechanisms of inflammatory reactions leading to testicular impairment. EAO is characterised by interstitial cell infi...

journal_title：Immunobiology

authors： Jarazo-Dietrich S,Jacobo P,Pérez CV,Guazzone VA,Lustig L,Theas MS

更新日期：2012-08-01 00:00:00

abstract：:The concept of using mesenchymal stem cells (MSCs) in bone repair has progressively evolved, and the goal of cell-mediated therapy is to prolong the natural physiological abilities of healing, or substitute them, when these are lacking, failing, or progressing too slowly. The future application of MSCs in human therap...

journal_title：Immunobiology

authors： Zhang X,Tang T,Shi Q,Fernandes JC,Dai K

更新日期：2009-01-01 00:00:00

abstract：:Macrophage functions in the immune response depend on their ability to infiltrate tissues and organs. The penetration between and within the tissues requires degradation of extracellular matrix (ECM), a function performed by the specialized, endopeptidase- and actin filament- rich organelles located at the ventral sur...

journal_title：Immunobiology

authors： Chen W,Ghobrial RM,Li XC,Kloc M

更新日期：2018-11-01 00:00:00

abstract：:Soluble MHC antigens are detected in body fluids but their role and origin are still unclear. This study examined whether serum IA antigens, isolated from BALB/c mice (sIA(d)), could modulate the immune response. Specific purification procedures isolated intact IA molecules, which were thereafter applied to functional...

journal_title：Immunobiology

authors： Marios-Frankiskos S,Panagiota M,Katerina B,Athanassakis I

更新日期：2010-03-01 00:00:00

abstract：:Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the TLRs are of considerable interest. Here we seek to determine the molecular mechanism by ...

journal_title：Immunobiology

authors： Zsengellér ZK,Gerard NP

更新日期：2020-03-01 00:00:00

abstract：:A case of a 35-year-old female with multiple sclerosis is reported who developed without apparent prior sensitization a lymphocytotoxic antibody with anti-HLA-B8 specificity. The antibody persisted for several years with the same titer. The cytotoxic activity of the patient's serum was contained within the IgM fractio...

journal_title：Immunobiology

authors： Lenhard V,Diehm H,Römer W,Rauterberg EW,Kownatzki E,Roelcke D

更新日期：1982-02-01 00:00:00

abstract：:To date, numerable reviews are found in the literature prominent to the effect of caffeine on the immune system, with the latest review published in 2006. Database screening reveals around three thousand articles that have been published during the last decade. Interestingly, less than hundred articles involved humans...

journal_title：Immunobiology

authors： Al Reef T,Ghanem E

更新日期：2018-12-01 00:00:00

abstract：:C1q binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. C1q binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology o...

journal_title：Immunobiology

authors： Sim RB,Kishore U,Villiers CL,Marche PN,Mitchell DA

更新日期：2007-01-01 00:00:00

abstract：:Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxi...

journal_title：Immunobiology

authors： Benczur M,Györffy G,Garam T,Varga M,Medgyesi G,Sándor M,Petranyi GG

更新日期：1979-09-01 00:00:00

abstract：:The tubercle bacillus is a facultative intracellular parasite that grows well in non-activated macrophages. When large numbers of these bacilli have grown intracellularly within such macrophages, a cytotoxic immune response, herein called tissue-damaging (or necrotizing) delayed-type hypersensitivity (DTH), kills the ...

journal_title：Immunobiology

authors： Dannenberg AM Jr

更新日期：1994-10-01 00:00:00

abstract：:C1r, the enzyme responsible for intrinsic activation of the C1 complex of complement, is a modular serine protease featuring an overall structural organization homologous to those of C1s and the mannan-binding lectin-associated serine proteases (MASPs). This review will initially summarize current information on the s...

journal_title：Immunobiology

authors： Arlaud GJ,Gaboriaud C,Garnier G,Circolo A,Thielens NM,Budayova-Spano M,Fontecilla-Camps JC,Volanakis JE

更新日期：2002-09-01 00:00:00

abstract：:CD8-positive cytotoxic T cells (CTL) recognize antigenic peptides in combination with major histocompatibility complex (MHC) class I molecules on the surface of syngeneic antigen presenting cells (APC). In the present paper we show that cells from tumor antigen-specific CTL clones present their cognate antigenic pepti...

journal_title：Immunobiology

authors： Staege MS,Schneider J,Eulitz M,Scholz S,Bornkamm GW,Wölfel T,Reske-Kunz AB

更新日期：2000-01-01 00:00:00

abstract：:Immunosuppressive effects of corticosteroids are generally known, but the mechanisms influencing the immune system are poorly understood. However, a correlation between cortisol levels and cytokine production has been reported by several investigators. In the present study we determined cortisol concentrations in huma...

journal_title：Immunobiology

authors： Reissland P,Wandinger KP

更新日期：1999-06-01 00:00:00

abstract：:Chemokine CCL21 can effectively attract CCR7(+) dendritic cells (DCs), however its role in this event is poorly understood. In this report, we investigated the effect of exogenous CCL21 expressed in breast cancer MCF-7 on human monocyte-derived DCs. CCL21-transfected MCF-7 stimulation prompted DC functions: migration,...

journal_title：Immunobiology

authors： Wu S,Xing W,Peng J,Yuan X,Zhao X,Lei P,Li W,Wang M,Zhu H,Huang B,Huang L,Shen G

更新日期：2008-01-01 00:00:00

abstract：:In order to evaluate the role of CD8+ T cells in cutaneous leishmaniasis, major histocompatibility complex (MHC) class II-deficient mice of C57BL/6 background lacking functional CD4+ T cells were infected with Leishmania major. In contrast to C57BL/6 wild-type mice which are resistant to infection with L. major, these...

journal_title：Immunobiology

authors： Erb K,Blank C,Ritter U,Bluethmann H,Moll H

更新日期：1996-07-01 00:00:00

abstract：:We studied immunohistological and biochemical aspects of the CD44 molecule with a mAb produced in our lab: GRHL-1. The characteristic expression of this antigen in cells of B lineage was analyzed. This mAb showed identical immunohistological patterns of reactivity to other mAbs included in CD44 cluster, on a variety l...

journal_title：Immunobiology

authors： Collado A,de Andres A,Cañadas E,Ruiz-Cabello F,Gomez O,Pedrinaci S,Garrido F

更新日期：1991-09-01 00:00:00

abstract：:The interaction between the T cell receptor (TCR) and the peptide-MHC complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC) is the main event controlling the specificity of antigen recognition by T cells. It is thought that TCR/pMHC binding kinetics are critical for the selection of ...

journal_title：Immunobiology

authors： Carreño LJ,González PA,Kalergis AM

更新日期：2006-01-01 00:00:00

abstract：:The Fc gamma RIII receptor (CD16) has been described on natural killer cells and a small subset of T lymphocytes. CD16+bright lymphocytes represent the typical population of peripheral blood CD3- NK cells. In these studies in addition to CD16+bright NK cells Fc gamma RIII expressing cytotoxic T lymphocytes in peripher...

journal_title：Immunobiology

authors： Uciechowski P,Werfel T,Leo R,Gessner JE,Schubert J,Schmidt RE

更新日期：1992-06-01 00:00:00

abstract：:Living organisms have strong defense mechanisms against invading microorganisms as survival strategies. One of the defense mechanisms is the complement system, composed of more than 30 serum and cell surface components. This system collaborates in recognition and elimination of pathogens as a part of both the innate a...

journal_title：Immunobiology

authors： Endo Y,Takahashi M,Fujita T

更新日期：2006-01-01 00:00:00

abstract：:It is well known that adherence of monocytes (MO) to extracellular matrix substrates or tissue culture plastic activates these cells and induces the expression of a multitude of genes. Especially, it was described, that MO are primed by cell adhesion to produce higher amounts of some cytokines, e.g. interleukin (IL)-8...

journal_title：Immunobiology

authors： Krause SW,Kreutz M,Andreesen R

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:The interaction between the immune system and malignant diseases is a proven key target for cancer therapy. We describe an innovative 3D cell culture system comprising both immune and cancer cells to evaluate their interaction and immune cell infiltration to provide an innovative in vitro screening of immu...

journal_title：Immunobiology

authors： Koeck S,Zwierzina M,Huber JM,Bitsche M,Lorenz E,Gamerith G,Dudas J,Kelm JM,Zwierzina H,Amann A

更新日期：2016-05-01 00:00:00

abstract：:Canine visceral leishmaniasis (CVL) is known to affect the cellular immunity of infected dogs, through impairing lymphoproliferation and microbicidal mechanisms. This study examined heme oxygenase-1 (HO-1) and its metabolites, oxidative stress and IL-10 levels in CVL and investigated correlations between these paramet...

journal_title：Immunobiology

authors： Almeida BF,Silva KL,Chiku VM,Leal AA,Venturin GL,Narciso LG,Fink MF,Eugênio FR,Santos PS,Ciarlini PC,Lima VM

更新日期：2017-05-01 00:00:00