Abstract:
:We have previously shown that human peripheral blood lymphocytes that do not adhere to natural killer (NK)-sensitive target cell monolayers are at least partially depleted of NK activity. To demonstrate directly that NK effector cells adhere to the monolayers, we have now recovered the adherent populations by treatment with ethylenediaminetetraacetic acid. When tested immediately after isolation, these adherent populations show NK activity that is intermediate between that of the nonadherent and control cells. When antibody-dependent cellular cytotoxicity is tested concomitantly, the adherent fractions are consistently found to be enriched relative to control, unfractionated lymphocytes. In further studies, control populations and fractions nonadherent and adherent to HSB monolayers are incubated overnight at 37 degrees C and then tested for NK activity. We find that the adherent fractions are selectively enhanced in activity, causing the NK activity of the adherent fractions to exceed that of control populations. The possible involvement of interferon in the augmentation of NK activity is considered.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Jensen PJ,Koren HSdoi
10.1016/S0171-2985(82)80052-1subject
Has Abstractpub_date
1982-05-01 00:00:00pages
494-506issue
5eissn
0171-2985issn
1878-3279pii
S0171-2985(82)80052-1journal_volume
161pub_type
杂志文章相关文献
IMMUNOBIOLOGY文献大全abstract::IL-33 targeting ST2 receptor (T1/ST2), expressed on Th2 cell surface, regulates the production of cytokines like IL-17A and IL-31. We studied the role of IL-33/ST2 axis in IL-31 and IL-17A production in patients with allergic rhinitis (AR) and with concomitant allergic asthma and rhinitis (AAR). 20 healthy control sub...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.02.005
更新日期:2015-08-01 00:00:00
abstract::The humoral immune response against alpha(1-->3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals, however, the response proceeds to a vigorous IgG production. In euthymic mice for...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(99)80046-1
更新日期:1999-09-01 00:00:00
abstract::Hepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient immune responses against the virus. HBV and its antigens are believed to suppress immune responses ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.07.020
更新日期:2014-12-01 00:00:00
abstract::Macrophages located in airways and the alveolar space are continually exposed to different signals from the respiratory mucosa. In this respect, epithelial cells represent an important source of cytokines and mediators modulating the state of activation and/or differentiation of mononuclear phagocytes. Many of the pro...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2011.04.009
更新日期:2011-10-01 00:00:00
abstract::The interaction between the T cell receptor (TCR) and the peptide-MHC complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC) is the main event controlling the specificity of antigen recognition by T cells. It is thought that TCR/pMHC binding kinetics are critical for the selection of ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2005.09.003
更新日期:2006-01-01 00:00:00
abstract::A "lectin-like" receptor for bacterial cell wall sugars, originally described in the membrane of mouse peritoneal macrophages, which facilitates binding of various bacteria to the macrophage surface, has now been shown to be present on most phagocytes from a variety of species. The role of such a receptor in the infla...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(82)80090-9
更新日期:1982-04-01 00:00:00
abstract::The alarming rise of obesity and type 2 diabetes (T2D) has put a tremendous strain on global healthcare systems. Over the past decade extensive research has focused on the role of macrophages as key mediators of inflammation in T2D. The inflammatory environment in the obese adipose tissue and pancreatic β-cell islets ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2016.08.011
更新日期:2017-10-01 00:00:00
abstract::In the thymus of non-obese diabetic (NOD) mice, the expression of the autoimmune regulator (Aire) gene varies with age, and its down-regulation in young mice precedes the later emergence of type 1 diabetes mellitus (T1D). In addition, the insulin (Ins2) peripheral tissue antigen (PTA) gene, which is Aire-dependent, is...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2012.02.005
更新日期:2013-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common neurodegenerative disease and it poses an ever-increasing burden to an aging population. Several loci responsible for the rare, autosomal dominant form of AD have been identified (APP, PS1 and PS2), and these have facilitated the development of the amyloid cascade hypothesis...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2011.07.017
更新日期:2012-02-01 00:00:00
abstract::Telomere erosion and residual replicative capacity can be used as markers of the replicative history of somatic cells. We have investigated telomere length, in vitro replicative capacity and rate of telomere erosion in T and B lymphocyte populations from patients with primary antibody deficiency requiring immunoglobul...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1078/0171-2985-00292
更新日期:2004-01-01 00:00:00
abstract::A review of 250 patients with the catastrophic antiphospholipid (Asherson's) syndrome (CAPS) taken from the web site organized by the Europhospholipid Group (http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) is presented in this paper. A short historical overview of the antiphospholipid syndrome (APS) is followed by a descr...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2005.10.002
更新日期:2005-01-01 00:00:00
abstract::Previous work has shown that purified rat macrophages lack both accessory activity for T lymphocyte responses to mitogens and stimulatory activity in a mixed leukocyte reaction, in marked contrast to the potent activity of dendritic cells. This study was designed to re-evaluate macrophages as accessory cells by treati...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(88)80052-4
更新日期:1988-02-01 00:00:00
abstract::B-1 cells can be differentiated from B-2 cells because they are predominantly located in the peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties. The role of both cell populations in cancer progression is still controversial. Previous studies have indicated that direct conta...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2012.07.032
更新日期:2013-04-01 00:00:00
abstract::Recent evidences suggest a significant role of Plasmacytoid dendritic cells (PDC) role in the pathogenesis of lupus erythematosus (LE) via production of type I IFN. Taking advantage on the availability of multiple reagents (CD123, BDCA2, and CD2ap) specifically recognizing PDC on fixed tissues, we investigated the occ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.06.013
更新日期:2009-01-01 00:00:00
abstract::The macrophage population of the gastro-intestinal tract of the rat was studied by using a set of three monoclonal antibodies (ED1, ED2 and ED3) directed against rat macrophages, an anti-Ia monoclonal antibody and by performing an acid phosphatase reaction. The lamina propria of the whole gastro-intestinal tract compr...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(86)80053-5
更新日期:1986-08-01 00:00:00
abstract::Cytophotometric measurements of DNA, dry mass (total proteins) and surface localized IgM and Ia were performed on individual cells of a Burkitt lymphoma derived cell line after X-irradiation and after polyploidization. Blockage of cell division was achieved with 250 r, and an arrest in G2 was found 48 hr after irradia...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(80)80099-4
更新日期:1980-07-01 00:00:00
abstract::The tubercle bacillus is a facultative intracellular parasite that grows well in non-activated macrophages. When large numbers of these bacilli have grown intracellularly within such macrophages, a cytotoxic immune response, herein called tissue-damaging (or necrotizing) delayed-type hypersensitivity (DTH), kills the ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(11)80452-3
更新日期:1994-10-01 00:00:00
abstract::The leukocyte integrins CD11a/CD18 (LFA-1, alphaLbeta2) and CD49d (VLA-4, alpha4beta1, alpha4beta7) mediate leukocyte transendothelial migration during immune and inflammatory responses and provides co-stimulatory signals for the activation of T lymphocytes. Our previous studies demonstrate that the CD11a gene promote...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2005.05.008
更新日期:2005-01-01 00:00:00
abstract::We have examined the role of CD26 (dipeptidyl peptidase IV) in the adhesion of resting and activated T lymphocytes to endothelial cells and fibroblasts. For this purpose, we ran a short-time adhesion assay under different strategies: Adhesion of T lymphocytes was determined in the presence of different anti-CD26 monoc...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(98)80053-3
更新日期:1998-02-01 00:00:00
abstract::The phenotype frequency of the platelet-specific antigens P1A1/A2 ( = Zw(a,b)) in the German population (N = 711) is 97.75% and 2.25% respectively. The corresponding gene frequencies are P1A1 0.85; P1A2 0.15. The P1A1 determinant is codominantly inherited (19 families; 151 family members). There is a strong gene dosag...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(82)80001-6
更新日期:1982-02-01 00:00:00
abstract::The Fc gamma RIII receptor (CD16) has been described on natural killer cells and a small subset of T lymphocytes. CD16+bright lymphocytes represent the typical population of peripheral blood CD3- NK cells. In these studies in addition to CD16+bright NK cells Fc gamma RIII expressing cytotoxic T lymphocytes in peripher...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80315-3
更新日期:1992-06-01 00:00:00
abstract::Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.07.009
更新日期:2016-12-01 00:00:00
abstract::Splenic B cells of BALB/c mice were stimulated in vitro either with lipopolysaccharide (LPS), dextran sulphate (DxS), or with both LPS and DxS. The absolute frequency of B cells that differentiate into clones of immunoglobulin (Ig)-secreting cells upon activation with these mitogens was determined by means of limiting...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(88)80060-3
更新日期:1988-02-01 00:00:00
abstract::Tumor necrosis factor superfamily (TNFSF) represents a group of multifunctional inflammatory cytokines that have been shown to participate in a variety of pathological and immunological process. However, the functions of these proteins in oyster are still poorly understood. In the present study, an oyster TNF homolog ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.02.002
更新日期:2017-05-01 00:00:00
abstract:AIM:To study the antiinflammatory effect of lidocaine in intestinal epithelial cells. METHODS:HT-29 and T-84 cells were grown in culture with and without TNF-alpha, lidocaine, aconitine and veratridine. The secretion of IL-8 and IP-10 was measured by ELISA. A cDNA microarray was used to assess gene expression. Real-ti...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.05.006
更新日期:2010-04-01 00:00:00
abstract::A case of a 35-year-old female with multiple sclerosis is reported who developed without apparent prior sensitization a lymphocytotoxic antibody with anti-HLA-B8 specificity. The antibody persisted for several years with the same titer. The cytotoxic activity of the patient's serum was contained within the IgM fractio...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(82)80002-8
更新日期:1982-02-01 00:00:00
abstract::Airway remodeling is a characteristic of bronchial asthma. The process involves the expression of many genes, such as transforming growth factor-beta (TGF-β), tissue inhibitors of metalloproteinases (TIMP-1), MMP and arginase. Human rhinovirus (HRV) is known to cause asthma exacerbations, and viral infections might be...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.05.010
更新日期:2017-08-01 00:00:00
abstract::IFN-γ produced during viral infections activates the IFN-γ receptor (IFNGR) complex for STAT1 transcriptional activity leading to expression of Interferon Regulatory Factors (IRF). Simultaneous activation of TBK/IKKε via TLR3 during viral infections activates the transcription factor IRF3. Together these transcription...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2019.04.004
更新日期:2019-07-01 00:00:00
abstract::Propranolol is a widely-known beta-blocker approved for treating infantile hemangiomas (IH). The mechanisms behind the spectacular IH involution after propranolol treatment remain unclear. Recently, there is strong evidence of overexpression of numerous angiogenic factors in IH tissues, and it is reported that propran...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.05.014
更新日期:2017-11-01 00:00:00
abstract::The majority of B lymphocytes, virgin T lymphocytes and a subpopulation of memory T cells express the addressin, L-selectin. Natural killer (NK) cells in rodents and humans also express L-selectin. We have shown that a similar proportion (40%) of NK cells in mouse spleen also express the integrin, CD18Mac-1, and moreo...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1078/0171-2985-00220
更新日期:2003-01-01 00:00:00