IL-33/ST2 axis controls Th2/IL-31 and Th17 immune response in allergic airway diseases.

abstract：:Peritoneal exudate T lymphocytes (PETLs) that mediate delayed-type hypersensitivity (DTH) to sheep red blood cells in mice were modified by in vitro treatment methods which modify surface carbohydrate constituents. Neuraminidase treatment resulted in the release of both N-acetylneuraminic acid and N-glycolyl-neuramini...

journal_title：Immunobiology

authors： Kaufmann SH,Schauer R,Hahn H

更新日期：1981-01-01 00:00:00

abstract：:Surfactant proteins SP-A and SP-D are pattern recognition innate immune molecules that belong to the C-type lectin family. In lungs, they play an important role in the clearance of pathogens and control of inflammation. SP-A and SP-D are also expressed in the female reproductive tract where they play an important role...

journal_title：Immunobiology

authors： Madhukaran SP,Koippallil Gopalakrishnan AR,Pandit H,Marri ED,Kouser L,Jamil K,Alhamlan FS,Kishore U,Madan T

更新日期：2016-02-01 00:00:00

abstract：:Macrophage pre-treatment with bacterial lipopolysaccharide (LPS) boosts subsequent activation of the NLRP3 inflammasome, which controls caspase-1-dependent pro-inflammatory cytokine maturation. Previous work has attributed this phenomenon (known as LPS 'priming') to LPS-dependent induction of NLRP3 expression. Whilst ...

journal_title：Immunobiology

authors： Schroder K,Sagulenko V,Zamoshnikova A,Richards AA,Cridland JA,Irvine KM,Stacey KJ,Sweet MJ

更新日期：2012-12-01 00:00:00

abstract：:Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile...

journal_title：Immunobiology

authors： Bonura A,Vlah S,Longo A,Bulati M,Melis MR,Cibella F,Colombo P

更新日期：2016-12-01 00:00:00

abstract：:Chemokine CCL21 can effectively attract CCR7(+) dendritic cells (DCs), however its role in this event is poorly understood. In this report, we investigated the effect of exogenous CCL21 expressed in breast cancer MCF-7 on human monocyte-derived DCs. CCL21-transfected MCF-7 stimulation prompted DC functions: migration,...

journal_title：Immunobiology

authors： Wu S,Xing W,Peng J,Yuan X,Zhao X,Lei P,Li W,Wang M,Zhu H,Huang B,Huang L,Shen G

更新日期：2008-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is an environmental sensor and ligand-activated transcription factor that is critically involved in the regulation of inflammatory responses and the induction of tolerance by modulating immune cells. As dendritic cells (DCs) express high AhR levels, they are efficient to induce immu...

journal_title：Immunobiology

authors： Michalski J,Deinzer A,Stich L,Zinser E,Steinkasserer A,Knippertz I

更新日期：2020-07-01 00:00:00

abstract：:In order to evaluate the role of CD8+ T cells in cutaneous leishmaniasis, major histocompatibility complex (MHC) class II-deficient mice of C57BL/6 background lacking functional CD4+ T cells were infected with Leishmania major. In contrast to C57BL/6 wild-type mice which are resistant to infection with L. major, these...

journal_title：Immunobiology

authors： Erb K,Blank C,Ritter U,Bluethmann H,Moll H

更新日期：1996-07-01 00:00:00

abstract：:Intravenous (i.v.) immunization of mice with irradiated (2000 rads) allogeneic lymphoid cells induces the generation of suppressor T cells. Such suppressor T cells can suppress the anti-host delayed type hypersensitivity (DTH) by other T cells during acute Graft-versus-Host reactions in irradiated recipient mice. Supp...

journal_title：Immunobiology

authors： Bril H,Molendijk-Lok BD,Hussaarts-Odijk LM,Benner R

更新日期：1985-04-01 00:00:00

abstract：:The vitamin D receptor (VDR) is a hormone nuclear receptor regulating bone and calcium homeostasis. Studies revealing the expression of VDR on immune cells point toward a role for VDR-dependent signaling pathways in immunity. Here we verified the ability of the natural VDR ligand, 1,25-dihydroxyvitamin D(3) (1,25(OH)(...

journal_title：Immunobiology

authors： Korf H,Wenes M,Stijlemans B,Takiishi T,Robert S,Miani M,Eizirik DL,Gysemans C,Mathieu C

更新日期：2012-12-01 00:00:00

abstract：:We have previously shown that human peripheral blood lymphocytes that do not adhere to natural killer (NK)-sensitive target cell monolayers are at least partially depleted of NK activity. To demonstrate directly that NK effector cells adhere to the monolayers, we have now recovered the adherent populations by treatmen...

journal_title：Immunobiology

authors： Jensen PJ,Koren HS

更新日期：1982-05-01 00:00:00

abstract：AIM:To study the antiinflammatory effect of lidocaine in intestinal epithelial cells. METHODS:HT-29 and T-84 cells were grown in culture with and without TNF-alpha, lidocaine, aconitine and veratridine. The secretion of IL-8 and IP-10 was measured by ELISA. A cDNA microarray was used to assess gene expression. Real-ti...

journal_title：Immunobiology

authors： Lang A,Ben Horin S,Picard O,Fudim E,Amariglio N,Chowers Y

更新日期：2010-04-01 00:00:00

abstract：:Immunosuppressive effects of corticosteroids are generally known, but the mechanisms influencing the immune system are poorly understood. However, a correlation between cortisol levels and cytokine production has been reported by several investigators. In the present study we determined cortisol concentrations in huma...

journal_title：Immunobiology

authors： Reissland P,Wandinger KP

更新日期：1999-06-01 00:00:00

abstract：:Previous work has shown that purified rat macrophages lack both accessory activity for T lymphocyte responses to mitogens and stimulatory activity in a mixed leukocyte reaction, in marked contrast to the potent activity of dendritic cells. This study was designed to re-evaluate macrophages as accessory cells by treati...

journal_title：Immunobiology

authors： Bowers WE,Ruhoff MS,Goodell EM,Stoltenborg JK

更新日期：1988-02-01 00:00:00

abstract：:Three different anti-CD26 monoclonal antibodies (mAbs) are described, which specifically inhibited proliferation of human T lymphocytes after stimulation with PHA, tetanus toxoid or soluble anti-CD3 mAb. Anti-CD26 mAbs induced in T cells a dose-dependent shift of the maximum of DNA synthesis, which was due to a transi...

journal_title：Immunobiology

authors： Mattern T,Ansorge S,Flad HD,Ulmer AJ

更新日期：1993-06-01 00:00:00

abstract：:A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of ...

journal_title：Immunobiology

authors： Peranzoni E,Marigo I,Dolcetti L,Ugel S,Sonda N,Taschin E,Mantelli B,Bronte V,Zanovello P

更新日期：2007-01-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is caused mainly by complement dysregulation. Although various defects in the complement system explaining pathophysiology have been described in recent years, the etiology still remains unclear in about thirty percent of cases. In exploring other causes, similar to anti- comp...

journal_title：Immunobiology

authors： Govindarajan S,Rawat A,Ramachandran R,Hans R,Dawman L,Tiewsoh K

更新日期：2020-09-01 00:00:00

abstract：:Leukocytes found at the human maternal-fetal interface participate in the inflammatory process associated with both preterm and term labor; therein, effective methods for their isolation that allow further phenotypic and functional analyses are necessary. Leukocyte isolation is usually carried out through scraping or ...

journal_title：Immunobiology

authors： MacDonald-Ramos K,Arenas-Hernandez M,Mancilla-Herrera I,Rangel-Escareño C,Vega-Sanchez R

更新日期：2019-01-01 00:00:00

abstract：:Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study,...

journal_title：Immunobiology

authors： Ogita T,Bergamo P,Maurano F,D'Arienzo R,Mazzarella G,Bozzella G,Luongo D,Sashihara T,Suzuki T,Tanabe S,Rossi M

更新日期：2015-06-01 00:00:00

abstract：:Immunocytochemical studies on both the light-microscopic and electron-microscopic levels proved that peritoneal resident macrophages derive from a precursor cell in the bone marrow. Evidence that this precursor cell differs from that of the monocyte is described. Progenitor cells of peritoneal resident macrophages wer...

journal_title：Immunobiology

authors： Daems WT,de Bakker JM

更新日期：1982-04-01 00:00:00

abstract：:Purified CD8+ T cells from influenza A/WSN-immune BALB/c (H-2d) mice respond with the generation of secondary A/WSN-specific Tc cells in vitro when stimulated with a synthetic peptide (NPP) with a sequence derived from influenza A virus nucleoprotein with high affinity for Kd class I MHC molecules. The process of the ...

journal_title：Immunobiology

authors： Kos FJ,Müllbacher A

更新日期：1992-11-01 00:00:00

abstract：:This is the first application of flow cytometry for the detection of lamina propria plasma cells and their intracellular immunoglobulins in patients with inflammatory bowel disease compared to healthy controls. The study has been focused on the distribution of IgA, IgG, IgM and the four IgG subclasses. Plasma cells we...

journal_title：Immunobiology

authors： Dorn I,Schlenke P,Mascher B,Stange EF,Seyfarth M

更新日期：2002-12-01 00:00:00

abstract：:The expression level of Mac-1 on the surface of neutrophils is an important indicator of neutrophil activation. Under pathological conditions, Mac-1 is believed a key adhesion molecule that facilitates cancer progression and mediates the adhesion of tumour cells to the endothelium of blood vessels. Our previous findin...

journal_title：Immunobiology

authors： Bednarska K,Klink M,Wilczyński JR,Szyłło K,Malinowski A,Sułowska Z,Nowak M

更新日期：2016-02-01 00:00:00

abstract：:Kinetic methods can provide significant information concerning the mechanism of cellular cytotoxicity reactions. Previous kinetic studies of cytotoxic T lymphocytes (Tc) have been hampered by the heterogeneity of the effector cell population tested. We therefore examined the kinetics of lysis mediated by cloned, IL 2 ...

journal_title：Immunobiology

authors： Callewaert DM,Meyers P,Hiernaux J,Radcliff G

更新日期：1988-12-01 00:00:00

abstract：:Blood dendritic cell precursors (DCps) are identified as mononuclear leukocytes expressing HLA-DR but lacking the characteristic antigens associated with T cells (CD3), NK cells (CD16 and CD56) and B cells (CD 19). Dendritic cell precursors are distinguished from monocytes by their lack of expression of CD64 rather th...

journal_title：Immunobiology

authors： Macey MG,Jawad N,McCarthy DA,Newland AC,Brown KA

更新日期：2000-05-01 00:00:00

abstract：:Dendritic cells capture and process antigen and present it to T lymphocytes in the lymphoid organs. Dendritic cells of the skin, including epidermal Langerhans cells, langerin(+) and langerin(negative) dermal dendritic cells are ideally positioned to take up pathogens that enter the body through the skin or vaccines t...

journal_title：Immunobiology

authors： Sparber F,Tripp CH,Hermann M,Romani N,Stoitzner P

更新日期：2010-09-01 00:00:00

abstract：:By quantitative and functional methods, changes were assessed in NK(ASGM-1+) cell numbers and NK cell-mediated lytic function of the spleen and bone marrow of mice bearing a tumor of hemopoietic origin (FLV-induced erythroleukemia) for 9 days +/- simultaneous administration of indomethacin (10 micrograms/ml drinking w...

journal_title：Immunobiology

authors： Christopher FL,Dussault I,Miller SC

更新日期：1991-12-01 00:00:00

abstract：:Defects in macrophage function have been implicated in the establishment of Crohn's disease (CD). However, the response of macrophages from CD patients to live bacteria, particularly Mycobacterium avium subsp. paratuberculosis (MAP), has not been addressed. Considering MAP has long been associated to CD, our objective...

journal_title：Immunobiology

authors： Campos N,Magro F,Castro AR,Cabral J,Rodrigues P,Silva R,Appelberg R,Rodrigues S,Lopes S,Macedo G,Sarmento A

更新日期：2011-08-01 00:00:00

abstract：:The inability of spontaneous and some laboratory-induced tumors to stimulate the immune system has continuously raised the question of the validity of using immunological maneuvers in order to control tumor growth. In this project we suggest that a tumor which is nonimmunogenic still has an immunogenic potential that ...

journal_title：Immunobiology

authors： Klein BY,Sharon R,Tarcic N,Naor D

更新日期：1982-10-01 00:00:00

abstract：:Considering that imbalance of central tolerance in the thymus contributes to aggressive autoimmunity, we compared the expression of peripheral tissue autoantigens (PTA) genes, which are involved in self-representation in the thymic stroma, of two mouse strains; DBA-1/J (MHC-H2(q)) susceptible and DBA-2/J (MHC-H2(d)) r...

journal_title：Immunobiology

authors： Donate PB,Fornari TA,Junta CM,Magalhães DA,Macedo C,Cunha TM,Nguyen C,Cunha FQ,Passos GA

更新日期：2011-05-01 00:00:00

abstract：:The polymorphonuclear neutrophil (PMN) regulates in vivo and in vitro immune responses. We report that the immunoenhancing properties of PMN culture supernatants from PMN recruited by the bacterium Actinomyces viscosus (AV) show its exclusive effects on the T cell lymphocyte population. A study of the effect of PMN su...

journal_title：Immunobiology

authors： Fitzgerald J,West K,Sonis S,Wilson R

更新日期：1983-12-01 00:00:00